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The protein encoded by CLCNKB is a member of the family of voltage-gated chloride channels. Additionally we are shipping CLCNKB Antibodies (49) and CLCNKB Proteins (4) and many more products for this protein.
Through the combined effects of pHi and pHo on ClC-K2, might be a key regulator of NaCl absorption.
IGF-1 (show IGF1 ELISA Kits), by stimulating ClC-K2 channels, promotes net Na(+) and Cl(-) reabsorption, thus reducing driving force for potassium secretion by the cortical collecting duct.
Five patients had 1 (show SLC35A2 ELISA Kits) or more mutations in CLCNKB, of whom 3 had homozygous mutations and 2 had single heterozygous mutations and only in CLCNKB had hypocalciuria.
Single loci of tag Single Nucleotide Polymorphisms of CLCNKA_B are not enough to increase the Essential Hypertension susceptibility, the combination of CLCNKA (show CLCNKA ELISA Kits) SNP, salt, marine products, meat, edible oil consumption is associated with elevated risk
results demonstrate that the carboxyl terminus of hClC-Kb is not part of the binding site for barttin (show BSND ELISA Kits), but functionally modifies the interplay with barttin (show BSND ELISA Kits).
These results demonstrate that mutations in a cluster of hydrophobic residues within transmembrane domain 1 affect barttin (show BSND ELISA Kits)-CLC-K interaction and impair gating modification by the accessory subunit
we report here for the first time that ClC-Kb disease-causing mutations located around the selectivity filter can result in both reduced surface expression and hyperactivity in heterologous expression systems
Case Report: 2 mutations in the CLCNKB gene, leading to a molecular diagnosis of Bartter syndrome type III in case of sudden infant death.
R8W and G47R, two naturally occurring barttin (show BSND ELISA Kits) mutations identified in patients with Bartter syndrome type IV, reduce barttin (show BSND ELISA Kits) palmitoylation and CLC-K/barttin (show BSND ELISA Kits) channel activity.
HEK293 cells the potentiating effect of niflumic acid (NFA) on CLC-Ka/barttin (show BSND ELISA Kits) and CLC-Kb/barttin (show BSND ELISA Kits) channels seems to be absent while the blocking efficacy of niflumic acid and benzofuran derivatives observed in oocytes is preserved
study investigated the functional consequences of seven mutations; four mutants carried no current whereas others displayed a 30-60 percent reduction in conductance as compared with wild-type ClC-Kb
expands the association between CLCNKB and essential hypertension to a non-European ancestry population
The open probability and mean open time of ClC-2 (show CLCN2 ELISA Kits) was voltage dependent, decreasing dramatically as the patches were depolarized. ClC-2 (show CLCN2 ELISA Kits) is uniquely suitable to promote anion secretion with little anion reabsorption.
The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
chloride channel Kb
, chloride channel Ka
, chloride channel protein ClC-Kb-like
, chloride channel K1-like; putative basolateral cTAL chloride channel ClC-Ka
, chloride channel protein ClC-Kb
, putative basolateral mTAL chloride channel ClC-Ka
, Chloride channel protein ClC-Kb
, chloride channel protein ClC-Ka
, chloride channel, kidney, B
, chloride channel K2