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Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Additionally we are shipping CLIC1 Antibodies (100) and CLIC1 Kits (11) and many more products for this protein.
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CLIC1 is a possible tumor marker for ovarian cancer. Dendritic cells pulsed with MtHsp70 (show HSPA9 Proteins)-CLIC1 can enhance antitumor immunity against ovarian cancer, providing a novel immune therapeutic strategy.
Either dysfunction or downregulation of CLIC1 can partially decrease the antineoplastic effects of metformin.
The expression of CLIC1 might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of pancreatic ductal adenocarcinomas.
Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth.
Results indicate that CLIC1 is an important contributor to tumor invasion, metastasis, and angiogenesis.
CLIC1 acts as a putative oncogene (show RAB1A Proteins) in pancreatic cancer.
Data show that glutamate (show GRIN1 Proteins) 85 and glutamate (show GRIN1 Proteins) 228 are pH-sensor residues of chloride intracellular channel protein CLIC1 and contribute to the pH-response stability in different ways.
CLIC1 and CLIC4 (show CLIC4 Proteins) are overexpressed in specific tumor types or their corresponding stroma and change localization and function from hydrophilic cytosolic to integral transmembrane proteins. (Review)
CLIC1 may be a potential sensitive and specific molecular biomarker for early diagnose for serous epithelial ovarian cancers metastasis.
It participates in migration and invasion of hepatocellular carcinoma by targeting maspin (show SERPINB5 Proteins).
Results indicate CLICs (CLIC1, CLIC4 (show CLIC4 Proteins) and CLIC5 (show CLIC5 Proteins))-dependent chloride efflux as an essential and proximal upstream event for NLRP3 (show NLRP3 Proteins) activation.
We conclude that the role of CLIC1 in macrophage superoxide production is to support redistribution of NADPH oxidase (show NOX1 Proteins) to the plasma membrane, and not through major effects on ERM (show ETV5 Proteins) cytoskeleton or by acting as a plasma membrane chloride channel (show CLCA1 Proteins).
Data, including data from studies in primary cells from knockout mice, suggest Clic1 and Clic4 (show CLIC4 Proteins) participate in signaling interleukin 1beta secretion and in activation of Nlrp3 (show NLRP3 Proteins) inflammasomes; in LPS (show TLR4 Proteins) macrophage activation, Clic1 and Clic4 (show CLIC4 Proteins) are translocated to nucleus/cell membranes. (Clic1 = chloride intracellular channel 1; Clic4 (show CLIC4 Proteins) = chloride intracellular channel 4 (show CLIC4 Proteins), mitochondrial; Nlrp3 (show NLRP3 Proteins) = NLR family pyrin domain containing 3 (show NLRP3 Proteins))
This study demonstrates for the first time that CLIC1 is overexpressed during AS development both in vitro and in vivo and can regulate the accumulation of inflammatory cytokines and production of oxidative stress.
Clic1 have a role in migration and invasion in hepatocarcinoma maybe via modulating the expression of Annexin A7 (show ANXA7 Proteins) and Gelsolin (show GSN Proteins).
These data all point to an important role for CLIC1 in regulating macrophage function through its ion channel activity.
The down-regulation of CLIC1 enhanced proliferative activity.
CLIC1 may play an important role in tumor metastasis.
CLIC1 is essential for the proliferation and invasion of hepatocellular carcinoma cells.
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family\; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
chloride intracellular channel 1
, RNCC protein
, chloride channel ABP
, chloride intracellular channel protein 1
, nuclear chloride ion channel 27
, nuclear chloride ion channel protein
, regulatory nuclear chloride ion channel protein