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Choline Kinase beta Proteins (CHKB)

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. Additionally we are shipping Choline Kinase beta Antibodies (36) and Choline Kinase beta Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHKB 1120 Q9Y259
CHKB 12651 O55229
CHKB 29367 O54783
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Top Choline Kinase beta Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,085.50
Details
HOST_HEK-293 Cells Human His tag   500 μg Log in to see 2 to 3 Days
$374.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CHKB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Choline Kinase beta (CHKB) Interaction Partners

Human Choline Kinase beta (CHKB) interaction partners

  1. A new form of congenital muscular dystrophy with multisystem involvement and characteristic mitochondrial structural changes, due to choline kinase beta gene defects has been characterized.

  2. A novel silent variant in the choline kinase beta causing muscular dystrophy.

  3. study identified a novel haplotype consisting of the indel variation, which had not been detected in previous studies in Japanese and Korean populations, and observed four single-nucleotide polymorphisms in CHKB/CPT1B (show CPT1B Proteins)

  4. CHKB encodes choline kinase beta, an enzyme that catalyzes the first de-novo biosynthetic step of phosphatidylcholine, the most abundant phospholipid in the eukaryotic membrane [review]

  5. CHKB activity was reduced in all three patients, significant reduction in choline:N-acetyl aspartate and choline:creatine ratios in keeping with a general decrease in the amount of choline and phosphocholine-based substrate

  6. The study extends on the observation of a strong multiethnic association of polymorphisms in the TCRA and P2RY11 with narcolepsy, but does not confirm the association of CPT1B (show CPT1B Proteins)/CHKB (rs5770917) in the Chinese population.

  7. homozygous or compound heterozygous mutations in the gene encoding choline kinase beta were identified in individulas with congenital muscular dystrophy.

  8. kinetic studies revealed that HC-3 (show PSMA2 Proteins) is a much more potent inhibitor for ChoKalpha isoforms (alpha1 and alpha2) compared with ChoKbeta.

  9. A single nucleotide polymorphism located between CPT1B (show CPT1B Proteins) and CHKB, was associated with narcolepsy in Japanese (rs5770917[C], odds ratio (OR) = 1.79, combined P = 4.4 x 10(-7)) and other ancestry groups (OR = 1.40, P = 0.02).

  10. Japanese CNS hypersomnias (essential hypersomnia: EHS) other than narcolepsy with cataplexy was significantly associated with SNP rs5770917 (located between CPT1B and CHKB) and HLA-DRB1*1501-DQB1*0602 haplotype

Mouse (Murine) Choline Kinase beta (CHKB) interaction partners

  1. CHKB is a new modulator of bone homeostasis

  2. Our data indicate that choline kinase beta plays an important role in endochondral bone formation by modulating growth plate physiology.

  3. Loss of choline kinase beta in skeletal muscle causes mitochondrial dysfunction and increased mitophagy.

  4. Experimental evidence for the presence of heteromeric ChoK/EtnK in any source. The activity of ChoK/EtnK in the cell is controlled not only by the level of each isoform but also by their combination to form the active oligomer complex.

  5. choline kinase beta is the first enzyme in phosphatidylcholine (show SGMS2 Proteins) biosynthesis and has a role in rostrocaudal muscular dystrophy

  6. The hindlimb muscular dystrophy in Chkb -/- mice is due to attenuated phosphatidylcholine (show SGMS2 Proteins) biosynthesis and enhanced catabolism of phosphatidylcholine (show SGMS2 Proteins).

Choline Kinase beta (CHKB) Protein Profile

Protein Summary

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family\; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus.

Gene names and symbols associated with Choline Kinase beta Proteins (CHKB)

  • choline kinase beta (LOC100353391)
  • choline kinase beta (CHKB)
  • choline kinase beta (Chkb)
  • Chetk protein
  • Chkl protein
  • Ck protein
  • Ck/Ek protein
  • Ck/Ek-beta protein
  • Ckb protein
  • Ckekb protein
  • Ek protein
  • EKB protein
  • MDCMC protein

Protein level used designations for Choline Kinase beta Proteins (CHKB)

choline kinase beta , choline kinase-like protein , choline/ethanolamine kinase , ethanolamine kinase beta , choline/ethanolamine kinase-b , choline/ethanolaminekinase , ethanolamine kinase , CK , CKB , CKEKB , EK , choline/ethanolamine kinase beta

GENE ID SPECIES
100353391 Oryctolagus cuniculus
1120 Homo sapiens
606800 Canis lupus familiaris
12651 Mus musculus
29367 Rattus norvegicus
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