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CHAT encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. Additionally we are shipping CHAT Kits (35) and CHAT Proteins (4) and many more products for this protein.
Showing 10 out of 109 products:
Dog (Canine) Polyclonal CHAT Primary Antibody for IF (p), IHC (p) - ABIN724070
Zhu, Zhao, Luo, Li: Gastrointestinal dysfunction in a Parkinson's disease rat model and the changes of dopaminergic, nitric oxidergic, and cholinergic neurotransmitters in myenteric plexus. in Journal of molecular neuroscience : MN 2012
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Human Monoclonal CHAT Primary Antibody for IHC (fro) - ABIN110750
Matthews, Salvaterra, Crawford, Houser, Vaughn: An immunocytochemical study of choline acetyltransferase-containing neurons and axon terminals in normal and partially deafferented hippocampal formation. in Brain research 1987
Show all 4 references for ABIN110750
Bird (Avian) Polyclonal CHAT Primary Antibody for IHC (fro), WB - ABIN372598
Karson, Casanova, Kleinman, Griffin: Choline acetyltransferase in schizophrenia. in The American journal of psychiatry 1993
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Bird (Avian) Polyclonal CHAT Primary Antibody for IEM, IHC (fro) - ABIN372597
Holt, Herman, Hyde, Kleinman, Sinton, German, Hersh, Graybiel, Saper: Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia. in Neuroscience 2000
Show all 2 references for ABIN372597
Dog (Canine) Polyclonal CHAT Primary Antibody for WB - ABIN374515
Madziar, Lopez-Coviella, Zemelko, Berse: Regulation of cholinergic gene expression by nerve growth factor depends on the phosphatidylinositol-3'-kinase pathway. in Journal of neurochemistry 2005
Human Polyclonal CHAT Primary Antibody for EIA, IF - ABIN951493
Need, Keefe, Ge, Grossman, Dickson, McEvoy, Goldstein: Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. in European journal of human genetics : EJHG 2009
Mouse (Murine) Polyclonal CHAT Primary Antibody for EIA, WB - ABIN782981
Contestabile, Fila, Bartesaghi, Contestabile, Ciani: Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases. in Journal of neurochemistry 2006
Microgravity causes substantial down-regulation of nerve tissue proteins, choline acetyltransferase, NF200 (show NEFH Antibodies), and calbindin (show CALB1 Antibodies) in mouse motor neurons.
These studies indicate a novel relationship between cholinergic neurons and APP (show APP Antibodies) processing, with 82-kDa ChAT acting as a negative regulator of Abeta (show APP Antibodies) production
increased REST/NRSF expression and its effect on the regulatory region for choline acetyltransferase (ChAT) transcription could explain the decreased expression of ChAT in the Alzheimer's disease transgenic mouse
chronic social defeat stress in mice produces stress-related behaviors; a decrease in the Chat level at days 12 and 27 was noted in the prefrontal cortex (PFC (show CFP Antibodies)), amygdala (Amyg), and dorsal hippocampus (HIP) in defeated mice
In choline acetyltransferase transgenic mice the activated cardiac ACh (show FGFR3 Antibodies)-HIF-1alpha (show HIF1A Antibodies) cascade improves survival after myocardial infarction.
After bilateral common carotid artery occlusion, peripherin (show PRPH Antibodies) overexpression was significantly correlated with reduction in ChAT activity
Histone deacetylase 9 (HDAC9 (show HDAC9 Antibodies)) represses ChAT gene expression in NG108-15 neuronal cells and thus plays an important role in cholinergic differentiation.
Transcripts encoding ChAT and OCT1 (show POU2F1 Antibodies)-3 (organic cation transport proteins) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen.
Gene upregulation of insulin (show INS Antibodies) and ChAT in the brain, but not of PPAR-delta (show PPARD Antibodies) or APP (show APP Antibodies), was evident in American ginseng-fed groups.
Results indicate that 17 beta-estradiol can influence the cholinergic system by increasing choline acetyltransferase expression in the mouse spinal cord.
We have identified a zebrafish mutant line, bajan, in which compromised motility and fatigue result from a point mutation in the gene coding choline acetyltransferase
Results suggest that SATB1 (show SATB1 Antibodies) is activated to bind to chromatin at S/MARs (show MARS Antibodies) after exposure to Abeta (show APP Antibodies) 1-42, resulting in alternative utilization and movement of 82-kDa ChAT to these regions demonstrating that both proteins play critical roles in the response of neural cells to acute Abeta (show APP Antibodies)-exposure.
We conducted a meta-analysis of studies involving CHAT, TFAM (show TFAM Antibodies), and VR22 (show CTNNA3 Antibodies) polymorphisms and Alzheimer disease susceptibility.For CHAT, rs2177369 (G>A) in whites and rs3810950 (G>A) in Asians were found to be associated with AD susceptibility. No association was detected between rs1880676 and rs868750 and AD risk.
There is a striking variability in the severity of phenotypes resulting from mutations in CHAT, which is the only gene so far known to be linked with congenital deficiency of ACh (show FGFR3 Antibodies) synthesis.
Data show thata the expression of choline acetyltransferase (ChAT) is reduced in the postmortem alcoholic basal forebrain in comparison to moderate drinking controls.
There was a loss of choline O-acetyltransferase in the visual cortex of dementia with Lewy bodies patients.
the functional consequences of 12 missense and one nonsense mutations of CHAT in 11 patients. ( choline acetyltransferase)
Multiple abnormalities with intellectual and developmental disability result from recurrent deletions and reciprocal duplications of 10q11.21q11.23 including CHAT and SLC18A3 (show SLC18A3 Antibodies).
The results revealed broad coexistence of ChAT and CGRP (show CALCA Antibodies) in the spinal cord neurons which implies that the neurons synthesize and store ChAT and CGRP (show CALCA Antibodies) in their cell bodies.
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.
, choline O-acetyltransferase
, choline acetylase
, acetyl CoA:choline O-acetyltransferase