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CHAT encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. Additionally we are shipping CHAT Antibodies (108) and CHAT Kits (38) and many more products for this protein.
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Microgravity causes substantial down-regulation of nerve tissue proteins, choline acetyltransferase, NF200 (show NEFH Proteins), and calbindin (show CALB1 Proteins) in mouse motor neurons.
These studies indicate a novel relationship between cholinergic neurons and APP (show APP Proteins) processing, with 82-kDa ChAT acting as a negative regulator of Abeta (show APP Proteins) production
increased REST/NRSF expression and its effect on the regulatory region for choline acetyltransferase (ChAT) transcription could explain the decreased expression of ChAT in the Alzheimer's disease transgenic mouse
chronic social defeat stress in mice produces stress-related behaviors; a decrease in the Chat level at days 12 and 27 was noted in the prefrontal cortex (PFC (show CFP Proteins)), amygdala (Amyg), and dorsal hippocampus (HIP) in defeated mice
In choline acetyltransferase transgenic mice the activated cardiac ACh (show FGFR3 Proteins)-HIF-1alpha (show HIF1A Proteins) cascade improves survival after myocardial infarction.
After bilateral common carotid artery occlusion, peripherin (show PRPH Proteins) overexpression was significantly correlated with reduction in ChAT activity
Histone deacetylase 9 (HDAC9 (show HDAC9 Proteins)) represses ChAT gene expression in NG108-15 neuronal cells and thus plays an important role in cholinergic differentiation.
Transcripts encoding ChAT and OCT1 (show POU2F1 Proteins)-3 (organic cation transport proteins) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen.
Gene upregulation of insulin (show INS Proteins) and ChAT in the brain, but not of PPAR-delta (show PPARD Proteins) or APP (show APP Proteins), was evident in American ginseng-fed groups.
Results indicate that 17 beta-estradiol can influence the cholinergic system by increasing choline acetyltransferase expression in the mouse spinal cord.
We have identified a zebrafish mutant line, bajan, in which compromised motility and fatigue result from a point mutation in the gene coding choline acetyltransferase
Results suggest that SATB1 (show SATB1 Proteins) is activated to bind to chromatin at S/MARs after exposure to Abeta (show APP Proteins) 1-42, resulting in alternative utilization and movement of 82-kDa ChAT to these regions demonstrating that both proteins play critical roles in the response of neural cells to acute Abeta (show APP Proteins)-exposure.
We conducted a meta-analysis of studies involving CHAT, TFAM (show TFAM Proteins), and VR22 (show CTNNA3 Proteins) polymorphisms and Alzheimer disease susceptibility.For CHAT, rs2177369 (G>A) in whites and rs3810950 (G>A) in Asians were found to be associated with AD susceptibility. No association was detected between rs1880676 and rs868750 and AD risk.
There is a striking variability in the severity of phenotypes resulting from mutations in CHAT, which is the only gene so far known to be linked with congenital deficiency of ACh (show FGFR3 Proteins) synthesis.
Data show thata the expression of choline acetyltransferase (ChAT) is reduced in the postmortem alcoholic basal forebrain in comparison to moderate drinking controls.
There was a loss of choline O-acetyltransferase in the visual cortex of dementia with Lewy bodies patients.
the functional consequences of 12 missense and one nonsense mutations of CHAT in 11 patients. ( choline acetyltransferase)
Multiple abnormalities with intellectual and developmental disability result from recurrent deletions and reciprocal duplications of 10q11.21q11.23 including CHAT and SLC18A3.
The results revealed broad coexistence of ChAT and CGRP (show CALCA Proteins) in the spinal cord neurons which implies that the neurons synthesize and store ChAT and CGRP (show CALCA Proteins) in their cell bodies.
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.
, choline O-acetyltransferase
, choline acetylase
, acetyl CoA:choline O-acetyltransferase