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Cholinergic Receptor, Nicotinic, alpha 1 (Muscle) Proteins (CHRNA1)

The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. Additionally we are shipping Cholinergic Receptor, Nicotinic, alpha 1 (Muscle) Antibodies (85) and Cholinergic Receptor, Nicotinic, alpha 1 (Muscle) Kits (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHRNA1 1134 P02708
Rat CHRNA1 CHRNA1 79557 P25108
CHRNA1 11435 P04756
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Top Cholinergic Receptor, Nicotinic, alpha 1 (Muscle) Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Torpedo californica His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Erinaceus concolor His tag   1 mg Log in to see 56 to 66 Days
$2,124.83
Details
Yeast Shrew His tag   1 mg Log in to see 56 to 66 Days
$2,124.83
Details
Yeast Herpestes ichneumon His tag   1 mg Log in to see 56 to 66 Days
$2,124.83
Details
Yeast Cat His tag   1 mg Log in to see 56 to 66 Days
$2,124.83
Details

CHRNA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Cholinergic Receptor, Nicotinic, alpha 1 (Muscle) (CHRNA1) Interaction Partners

Human Cholinergic Receptor, Nicotinic, alpha 1 (Muscle) (CHRNA1) interaction partners

  1. Cholesterol and CAV-1 (show CAV1 Proteins) modulate the function and dynamics of the slow channel congenital myasthenia syndrome alphaC418W nicotinic acetylcholine receptor mutation.

  2. nicotine contributes to the progression and erlotinib-resistance of the NSCLC xenograft model via the cooperation between nAChR (show CHRNA4 Proteins) and EGFR (show EGFR Proteins).

  3. show that AON complementary to the 5' splice site of the exon was the most effective at exon skipping of the minigene with causative mutations, as well as endogenous wild-type CHRNA1

  4. The CHRNA1 extracellular domain is an improved protein for use in antigen-specific Myasthenia Gravis therapeutic strategies.

  5. HnRNP L (show HNRNPL Proteins) and hnRNP (show HNRNPC Proteins) LL antagonistically modulate PTB (show PTBP1 Proteins)-mediated splicing suppression of CHRNA1 pre-mRNA.

  6. High expression of CHRNA1 is associated with lung adenocarcinoma after complete resection.

  7. No mutations were found in CHRNG (show CHRNG Proteins), CHRND (show CHRND Proteins) and CHRNA1 genes of Indian families with Escobar syndrome.

  8. Findings identify a novel lung cancer risk locus on 2q31.1 which correlates with CHRNA1 expression and replicate previous associations on 15q25.1 in African-Americans.

  9. V188 is functionally linked to Y190 in the C-loop and to D200 in beta-strand 10 of the acetylcholine receptor alpha subunit (show POLG Proteins), which connects to the M1 transmembrane domain

  10. Studies suggest that the receptor nAChRalpha1 is an important regulator of calpain-1 (show CAPN1 Proteins) activation and inflammation in the chronic hypercholesterolemic nephropathy.

Mouse (Murine) Cholinergic Receptor, Nicotinic, alpha 1 (Muscle) (CHRNA1) interaction partners

  1. This study demonstrates that genes coding for CHRNA1 subunits may contain variants associated with statin-induced ADRs.

  2. Chrna1 was co-purified with nicotinic acetylcholine receptor (AChR) in C2C12 myotubes. In addition, Stau1 (show STAU1 Proteins) was found to interact with Chrna1 mRNA, and knocking down of Stau1 (show STAU1 Proteins) by RNAi resulted in defective AChR clustering.

  3. These results suggest that in skeletal muscle cells, neural activity reduces the molar ratio of YB-1 (show YBX1 Proteins) relative to its binding AChR alpha mRNA, leading to an increase of ribosome binding to the mRNA, and thus activating translation.

  4. Chrna1 could be the first transcriptional target of atonal homolog 1 in the inner ear

  5. These data identify caveolin-3 (show CAV3 Proteins) as a critical component of the signaling machinery that drives nicotinic acetylcholine receptor clustering and controls neuromuscular junction function.

  6. HDAC4 (show HDAC5 Proteins) is a neural activity-regulated deacetylase and a key signaling component that relays neural activity to the muscle transcriptional machinery through Dach2 (show DACH2 Proteins), myogenin (show MYOG Proteins), and nAChR (show CHRNA4 Proteins)

  7. In S269I, mutant the peak-current amplitude decreases along trains of nearly saturating ACh (show FGFR3 Proteins) pulses delivered at physiologically relevant frequencies, consistent with enhanced entry into desensitization in congenital myasthenic syndrome.

  8. In this mouse experiemntal myasthenia gravis study demonstrated that Acetylcholine receptor-alpha1 subunit expression was increase with varying disease severity.

Cholinergic Receptor, Nicotinic, alpha 1 (Muscle) (CHRNA1) Protein Profile

Protein Summary

The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with CHRNA1

  • acetylcholine receptor alpha subunit (ACHR)
  • cholinergic receptor, nicotinic, alpha 1 (muscle) (CHRNA1)
  • cholinergic receptor, nicotinic, alpha 1 (muscle) (Chrna1)
  • cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) (Chrna1)
  • Achr-1 protein
  • ACHRA protein
  • ACHRD protein
  • Acra protein
  • AI385656 protein
  • AI608266 protein
  • CHRNA protein
  • CHRNA1 protein
  • CMS2A protein
  • FCCMS protein
  • NACHRA1 protein
  • SCCMS protein

Protein level used designations for CHRNA1

acetylcholine receptor subunit alpha , acetylcholine receptor, nicotinic, alpha 1 (muscle) , cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) , muscle nicotinic acetylcholine receptor , nicotinic acetylcholine receptor alpha subunit , nicotinic cholinergic receptor alpha 1 , muscle nicotinic acetylcholine receptor alpha-su exon P4 , nachr alpha-subunit , nicotinic acetylcholine recepter alpha-subunit , cholinergic receptor nicotinic alpha polypeptide 1 , alpha-1 subunit, nicotinic acetylcholine receptor , nicotinic cholinergic receptor alpha polypeptide 1

GENE ID SPECIES
751106 Felis catus
1134 Homo sapiens
403757 Canis lupus familiaris
338070 Bos taurus
79557 Rattus norvegicus
395608 Gallus gallus
396587 Sus scrofa
101110120 Ovis aries
11435 Mus musculus
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