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Cholinergic Receptor, Nicotinic, alpha 2 (Neuronal) Proteins (CHRNA2)

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Additionally we are shipping CHRNA2 Antibodies (25) and CHRNA2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHRNA2 1135 Q15822
Rat CHRNA2 CHRNA2 170945 P12389
CHRNA2 110902 Q91X60
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Top CHRNA2 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

CHRNA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
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More Proteins for Cholinergic Receptor, Nicotinic, alpha 2 (Neuronal) (CHRNA2) Interaction Partners

Human Cholinergic Receptor, Nicotinic, alpha 2 (Neuronal) (CHRNA2) interaction partners

  1. The rare variants in CHRNA2 were significantly associated with smoking status.

  2. a heterozygous single-nucleotide substitution in CHRNA2 gene (c.1126 C>T; p. Arg376Trp) in subjects with benign familial infantile seizures

  3. CHRNA2 mutations play a causative role in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE).

  4. Results show that D478E variation in nAChR (show CHRNA4 Proteins) alpha2 subunit increases the peak current responses of both alpha2beta2- and alpha2beta4-nAChRs; but the D478N variation in nAChR (show CHRNA4 Proteins) alpha2 subunit only increases the peak current responses of alpha2beta2-nAChRs

  5. Level of cigarettes per day during adolescence and young adulthood is associated with CHRNB3A6, CHRNA5A3B4, and CHRNA2

  6. Results indicate that the CHRNA2 signal peptide mutation T22I modulates the function of both alpha2beta2- and alpha2beta4-nAChR (show CHRNA4 Proteins) and decreases sensitivities to nicotine and acetylcholine, and quite possibly increasing susceptibility to nicotine dependence

  7. findings indicate that both CHRNA2 and CHRNA6 play a significant role in the etiology of ND in AA and EA smokers

  8. mutations of CHRNB2 and CHRNA2 genes may be rare in Chinese autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) population.

  9. A new CHRNA2 mutation markedly increases the receptor sensitivity to acetylcholine, indicating that the nicotinic alpha 2 subunit alteration is the underlying cause.

  10. From a panel of 59 single-nucleotide polymorphisms (SNPs) located on 11 candidate genes, we identify four SNPs (one each on CHRNA5 (show CHRNA5 Proteins) and CHRNA2 and two on CHAT) that appear to have pharmacogenetic relevance in smokin cessation therapy.

Mouse (Murine) Cholinergic Receptor, Nicotinic, alpha 2 (Neuronal) (CHRNA2) interaction partners

  1. Study described Chrna2 expression in the amygdala and propose that this expression is a marker of the medial subpallium-derived amygdala

  2. The results of this study suggested that loss of the mouse nAChR (show CHRNA4 Proteins) alpha2 subunit has very limited effects on baseline behavior but does lead to the potentiation of several nicotine-modulated behaviors.

CHRNA2 Protein Profile

Protein Summary

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.

Gene names and symbols associated with CHRNA2

  • neuronal acetylcholine receptor subunit alpha-2 (CpipJ_CPIJ002436)
  • neuronal acetylcholine receptor subunit alpha-2 (Tsp_10995)
  • neuronal acetylcholine receptor subunit alpha-2-like (LOC100370261)
  • cholinergic receptor, nicotinic, alpha 2 (neuronal) (CHRNA2)
  • cholinergic receptor, nicotinic, alpha 2 (neuronal) (Chrna2)
  • cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) (Chrna2)
  • ACHR protein
  • Acra-2 protein
  • Acra2 protein
  • BC011490 protein
  • NACHRA2 protein

Protein level used designations for CHRNA2

neuronal acetylcholine receptor subunit alpha-2 , neuronal acetylcholine receptor subunit alpha-2-like , cholinergic receptor, nicotinic, alpha 2 (neuronal) , acetylcholine receptor, nicotinic, alpha 2 (neuronal) , cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) , nicotinic acetylcholine receptor , alpha-2 subunit, nicotinic acetylcholine receptor

GENE ID SPECIES
6033618 Culex quinquefasciatus
10903459 Trichinella spiralis
100370261 Saccoglossus kowalevskii
100403598 Callithrix jacchus
100451356 Pongo abelii
1135 Homo sapiens
170945 Rattus norvegicus
395607 Gallus gallus
472725 Pan troglodytes
110902 Mus musculus
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