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Cholinergic Receptor, Nicotinic, alpha 3 (Neuronal) Proteins (CHRNA3)

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Additionally we are shipping Cholinergic Receptor, Nicotinic, alpha 3 (Neuronal) Antibodies (64) and Cholinergic Receptor, Nicotinic, alpha 3 (Neuronal) Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHRNA3 1136 P32297
Rat CHRNA3 CHRNA3 25101  
CHRNA3 110834 Q8R4G9
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Top Cholinergic Receptor, Nicotinic, alpha 3 (Neuronal) Proteins at antibodies-online.com

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CHRNA3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for Cholinergic Receptor, Nicotinic, alpha 3 (Neuronal) (CHRNA3) Interaction Partners

Human Cholinergic Receptor, Nicotinic, alpha 3 (Neuronal) (CHRNA3) interaction partners

  1. Our data suggest that gene variance in the CHRNA5 (show CHRNA5 Proteins)-CHRNA3-CHRNB4 cluster is associated with an increased risk of death, incidence of COPD (show ARCN1 Proteins) and tobacco-related cancer in smokers.

  2. two SNPs (rs6495308 and rs11072768) in CHRNA5-A3-B4 have a indirect effect on lung cancer through smoking behaviors

  3. CHRNA3 - candidate gene for Chronic Obstructive Pulmonary Disease identified by Genome-wide association studies.

  4. Data suggest that CHRNA5-A3-B4 gene variants do not exhibit a robust association with smoking cessation and are unlikely to be useful for clinically optimizing smoking cessation pharmacotherapy for Caucasian smokers.

  5. The positive interaction between heavy smoking and the homozygous mutant CHRNA3 rs6495308 genotype was found to affect the likelihood of hypertension in Chinese male smokers.

  6. Four SNPs in the CHRNA3/5 locus are associated with chronic obstructive pulmonary disease risk. [Meta-analysis]

  7. CHRNA5-A3-B4 genotype associates with body mass index in never smokers.

  8. Of the 2305 SNPs identified in the CHRNA3 gene, 115 were found to be non-synonymous and 12 and 15 nsSNPs were found to be in the 5' and 3' UTRs, respectively. 115 nsSNPs investigated, eight were predicted to be deleterious by both SIFT and PredictSNP servers.

  9. Our findings demonstrated that CHRNA3 gene rs6495309 polymorphism might be a risk factor for the development of lung cancer in Chinese.

  10. Study provides new evidence that the overexpression of the CHRNA5/A3/B4 region disrupts pyramidal neuronal structure in the hippocampus, and thus affecting the cognitive capacities

Cow (Bovine) Cholinergic Receptor, Nicotinic, alpha 3 (Neuronal) (CHRNA3) interaction partners

  1. Data show that a basic residue at position 210 of alpha3 subunit decreases the assembly of heteromeric neuronal alpha3beta4 nicotinic ACh (show FGFR3 Proteins) receptors.

Pig (Porcine) Cholinergic Receptor, Nicotinic, alpha 3 (Neuronal) (CHRNA3) interaction partners

  1. Sympathetic alpha3beta2-nAChRs (CHRNA3/CHRNB2) mediate basilar artery neurogenic nitrergic vasodilation in swine.

Mouse (Murine) Cholinergic Receptor, Nicotinic, alpha 3 (Neuronal) (CHRNA3) interaction partners

  1. neuroinflammation is sufficient to provoke the decrease of a7 and a4b2 nAChRs, Ab42 accumulation and memory impairment in mice and a7(1-208) nAChR (show CHRNA4 Proteins)-specific antibodies can cause inflammation of the brain with symptoms typical for Alzheimer disease

  2. The alpha3beta4* nicotinic ACh (show FGFR3 Proteins) receptor subtype mediates physical dependence to morphine

  3. The present findings suggest that its thymic production and/or release are under cholinergic control involving nAChR (show CHRNA4 Proteins) containing the alpha3-subunit.

  4. Downregulation of nAChR (show CHRNA4 Proteins) subunit and PSD-93 (show DLG2 Proteins) expression after cavernous nerve injury, or even manipulation, could interrupt synaptic transmission within the MPG (show MPG Proteins) and thus contribute to the loss of neural control of urogenital organs after pelvic surgeries.

  5. findings suggest an important role for the a3b4* nAChR (show CHRNA4 Proteins) subtype in nicotine reward and physical aspects of the nicotine withdrawal syndrome.

  6. Greater expression of Chrna3 is found in whole brain and dissected brain regions relevant to locomotor behavior in mice that are less sensitive to ethanol-induced stimulation compared to mice that are robustly stimulated.

  7. Polymorphisms located within the Chrna5-Chrna3-Chrnb4 cluster on mouse chromosome 9 were found to co-segregate with alcohol preference, with high-drinking F(2) mice carrying B6 alleles and low-drinking F(2) mice carrying D2 alleles.

  8. The results of this study demonstrated that hyperglycemia also interferes with the function of alpha3-containing nAChRs through Cys (show DNAJC5 Proteins) residues on the alpha3 subunit

  9. functional nicotinic ACh (show FGFR3 Proteins) receptors are detected on stem and progenitor cells of fetal mouse cerebral cortex as early as embryonic day 10

  10. Our results suggest that PrP(C (show PRNP Proteins)) is a member of a multiprotein membrane complex participating in the formation and function of alpha3beta4 nAChR (show CHRNA4 Proteins).

Cholinergic Receptor, Nicotinic, alpha 3 (Neuronal) (CHRNA3) Protein Profile

Protein Summary

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with CHRNA3

  • cholinergic receptor, nicotinic, alpha 3 (CHRNA3)
  • cholinergic receptor, nicotinic, alpha 3 (neuronal) (CHRNA3)
  • cholinergic receptor, nicotinic, alpha 3 (neuronal) (Chrna3)
  • cholinergic receptor, nicotinic, alpha polypeptide 3 (Chrna3)
  • (a)3 protein
  • A730007P14Rik protein
  • Acra-3 protein
  • Acra3 protein
  • LNCR2 protein
  • NACHRA3 protein
  • PAOD2 protein

Protein level used designations for CHRNA3

cholinergic receptor, nicotinic, alpha polypeptide 3 , neuronal acetylcholine receptor subunit alpha-3 , neuronal nicotinic acetylcholine receptor, alpha3 subunit , Acetylcholine receptor alpha 3 (neuronal nicotine) , cetylcholine receptor alpha 3 (neuronal nicotine) , cholinergic receptor nicotinic alpha polypeptide 4 , alpha 3 , neuronal nicotinic acetylcholine receptor, alpha 3 subunit

GENE ID SPECIES
386578 Gallus gallus
1136 Homo sapiens
482111 Canis lupus familiaris
282702 Bos taurus
25101 Rattus norvegicus
100151989 Sus scrofa
110834 Mus musculus
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