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anti-Cholinergic Receptor, Nicotinic, alpha 4 (CHRNA4) Antibodies

CHRNA4 encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. Additionally we are shipping Cholinergic Receptor, Nicotinic, alpha 4 Proteins (7) and Cholinergic Receptor, Nicotinic, alpha 4 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CHRNA4 1137 P43681
CHRNA4 25590 P09483
CHRNA4 11438 O70174
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Top anti-Cholinergic Receptor, Nicotinic, alpha 4 Antibodies at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-CHRNA4 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-CHRNA4 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB ABIN334375 (0.3µg/ml) staining of Rat Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$221.76
Details
Rat Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-CHRNA4 Polyclonal Antibody, Unconjugated (ABIN736746) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded human glioma labeled with Anti-CHRNA4 Polyclonal Antibody, Unconjugated (ABIN736746) at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details

CHRNA4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Cholinergic Receptor, Nicotinic, alpha 4 Antibodies

  1. Chicken Polyclonal CHRNA4 Primary Antibody for WB - ABIN2776101 : Fedi, Bach, Berkovic, Willoughby, Scheffer, Reutens: Association of a nicotinic receptor mutation with reduced height and blunted physostigmine-stimulated growth hormone release. in The Journal of clinical endocrinology and metabolism 2008 (PubMed)
    Show all 2 references for ABIN2776101

  2. Human Polyclonal CHRNA4 Primary Antibody for ELISA, WB - ABIN334375 : Schwarz, Schwarz, Dorigo, Stützer, Wegner, Labarca, Deshpande, Gil, Berk, Lester: Enhanced expression of hypersensitive alpha4* nAChR in adult mice increases the loss of midbrain dopaminergic neurons. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 (PubMed)

  3. Human Polyclonal CHRNA4 Primary Antibody for ELISA, WB - ABIN334374 : Bertrand, Picard, Le Hellard, Weiland, Favre, Phillips, Bertrand, Berkovic, Malafosse, Mulley: How mutations in the nAChRs can cause ADNFLE epilepsy. in Epilepsia 2002 (PubMed)

More Antibodies against Cholinergic Receptor, Nicotinic, alpha 4 Interaction Partners

Zebrafish Cholinergic Receptor, Nicotinic, alpha 4 (CHRNA4) interaction partners

  1. and chrna4 RNAs were each expressed in a unique pattern, which changed during development

Human Cholinergic Receptor, Nicotinic, alpha 4 (CHRNA4) interaction partners

  1. Study observed a significant association between the rs1044396 SNP in the CHRNA4 gene and the personality trait harm avoidance

  2. Results provide further evidence that common synonymous CHRNA4 exon 5 SNPs affect cognitive processes and suggest that they also play a role in the auditory system.

  3. Common CHRNA4 variant with important regulatory properties that contributes to nicotine dependence and smoking-related consequences was identified.

  4. the identity of subunits neighboring the otherwise equivalent alpha4(+)/(-)beta2 agonist sites modifies their contributions to nAChR activation and E-loop residues are an important contributor to this neighbor effect

  5. findings demonstrate that the complementary alleles of the CHRNA4 exon 5 haplotype differ with respect to mRNA stability, codon usage and agonist sensitivity

  6. CHRNA4 rs1044396 CT/TT genotype is related to cigarette smoking in Parkinson's disease patients.

  7. study demonstrated that genetic variation of CHRNA4 (rs1044396) increased blink (show TGFb Antibodies) rate while watching a video; suggests that differences in sensitivity to acetylcholine because of the genetic variation are associated with individual differences in spontaneous eye blink (show TGFb Antibodies) rate

  8. Study investigated whether the rs1044396 polymorphism of the CHRNA4 gene modulates response speed and selective visual attention in the Stroop task, Negative priming task, and Posner-Cuing task in n = 157 healthy participants

  9. Description of a de novo missense mutation in the transmembrane domain M2 segment of CHRNA (show CHRNA1 Antibodies)$, c.823A>T, which decreased the surrounding hydrophobicity and slightly altered secondary structure of the protein

  10. Variants in CHRNA4 may contribute to risk of binge drinking in young adults.

Mouse (Murine) Cholinergic Receptor, Nicotinic, alpha 4 (CHRNA4) interaction partners

  1. The alpha4 nAChR subunit is regulated by protein kinase C epsilon (show PRKCE Antibodies) phosphorylation.

  2. neuroinflammation is sufficient to provoke the decrease of a7 and a4b2 nAChRs, Ab42 accumulation and memory impairment in mice and a7(1-208) nAChR-specific antibodies can cause inflammation of the brain with symptoms typical for Alzheimer disease.

  3. Lynx2 and Ly6g6e have roles in intracellular trafficking and allosteric potentiation of alpha4beta2 nAChRs, respectively

  4. The study shows that nAChR alpha4 beta2 sensitizes a MAPK (show MAPK1 Antibodies)-linked toxicity pathway on prolonged exposure to ABETA (show APP Antibodies) (1-42).

  5. This study has revealed complex effects of Chrna4 deficiency and prenatal nicotine exposure on ventilatory and metabolic interactions and responses to stress.

  6. It indicated that Correlation between nAChalpha4-, 5-HT1A (show HTR1A Antibodies)- and 5-HT7 (show HTR7 Antibodies)-containing receptors and latencies on day 16 may point to a probable link in extinction mechanisms.

  7. These results question the conclusion that a dominant-negative mechanism would explain the dominance of the mutant L501fsX533 Fz4 (show FZD4 Antibodies) allele in the transmission of a form of Familial exudative vitreoretinopathy.

  8. Study demonstrates that chronic pre-exposure to nicotine at a dosing regimen that results in maximal alpha4 nAChR upregulation results in significantly elevated oral nicotine self-administration in a two-bottle choice paradigm in mice

  9. Lynx1 (show LYNX1 Antibodies) has a role in shifting alpha4beta2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum

  10. these data indicate that a4-nAChR have an impact on motor output.

Cholinergic Receptor, Nicotinic, alpha 4 (CHRNA4) Antigen Profile

Protein Summary

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with CHRNA4

  • neuronal acetylcholine receptor subunit alpha-4 (CpipJ_CPIJ002434) antibody
  • Neuronal acetylcholine receptor subunit alpha-4-like (LOC100368057) antibody
  • cholinergic receptor, nicotinic, alpha 4 (CHRNA4) antibody
  • neuronal acetylcholine receptor subunit alpha-4-like (LOC100434875) antibody
  • cholinergic receptor, nicotinic, alpha 4 (chrna4) antibody
  • cholinergic receptor, nicotinic, alpha 4 (neuronal) (CHRNA4) antibody
  • cholinergic receptor, nicotinic, alpha 4 (neuronal) (Chrna4) antibody
  • cholinergic receptor, nicotinic, alpha polypeptide 4 (Chrna4) antibody
  • Acra-4 antibody
  • Acra4 antibody
  • BFNC antibody
  • EBN antibody
  • EBN1 antibody
  • ENFL1 antibody
  • NACHR antibody
  • NACHRA4 antibody
  • NACRA4 antibody
  • NARAC antibody

Protein level used designations for CHRNA4

neuronal acetylcholine receptor subunit alpha-4 , Neuronal acetylcholine receptor subunit alpha-4-like , cholinergic receptor, nicotinic, alpha 4 , neuronal acetylcholine receptor subunit alpha-4-like , neuronal nicotinic acetylcholine receptor alpha 4 subunit , alpha-4 subunit, nicotinic acetylcholine receptor , cholinergic receptor, nicotinic, alpha polypeptide 4 , neuronal nicotinic acetylcholine receptor alpha-4 subunit , Neuronal nicotinic acetylcholine receptor alpha 4 subunit , cholinergic receptor, nicotinic, alpha 4 subunit , neuronal acetylcholine receptor alpha-4 subunit , a4 nicotinic receptor , acetylcholine receptor alpha 4 neural , acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit , alpha4 nAChR , alpha4-nAChR

GENE ID SPECIES
6033616 Culex quinquefasciatus
100368057 Saccoglossus kowalevskii
100405714 Callithrix jacchus
100434875 Pongo abelii
537251 Bos taurus
556619 Danio rerio
395606 Gallus gallus
1137 Homo sapiens
25590 Rattus norvegicus
485972 Canis lupus familiaris
469999 Pan troglodytes
11438 Mus musculus
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