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The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. Additionally we are shipping CHRNA7 Proteins (8) and CHRNA7 Kits (7) and many more products for this protein.
Showing 10 out of 70 products:
Human Polyclonal CHRNA7 Primary Antibody for IHC (fro), IP - ABIN493153
Severance, Zhang, Cruz, Pakhlevaniants, Hadley, Amin, Wecker, Reed, Cuevas: The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channels. in Molecular pharmacology 2004
Show all 3 references for ABIN493153
Human Polyclonal CHRNA7 Primary Antibody for WB - ABIN657819
Chernyavsky, Arredondo, Galitovskiy, Qian, Grando: Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases. in American journal of physiology. Cell physiology 2010
Show all 2 references for ABIN657819
Human Polyclonal CHRNA7 Primary Antibody for EIA, IHC (p) - ABIN1449425
Ren, King, Liu, Siemann, Altman, Meyers, Hughes, Meyer: The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice. in Neuroscience 2007
Human Polyclonal CHRNA7 Primary Antibody for EIA, IHC (fro) - ABIN113048
Lips, Brüggmann, Pfeil, Vollerthun, Grando, Kummer: Nicotinic acetylcholine receptors in rat and human placenta. in Placenta 2005
Chicken Polyclonal CHRNA7 Primary Antibody for WB - ABIN2792250
Avramopoulou, Mamalaki, Tzartos: Soluble, oligomeric, and ligand-binding extracellular domain of the human alpha7 acetylcholine receptor expressed in yeast: replacement of the hydrophobic cysteine loop by the hydrophilic loop of the ACh-binding protein enhances protein solubility. in The Journal of biological chemistry 2004
We conclude that residues in the M2 segment and flanking regions contribute to the unusual properties of the CHRNA7 receptor
Loop 3 and its docking to the alpha-helix is an important requirement for receptor assembly of the alpha7 nicotinic receptor.
a network of interactions formed by residues Lys (show LYZ Antibodies)-46, Asp (show ASIP Antibodies)-128, Asp (show ASIP Antibodies)-135, Asp (show ASIP Antibodies)-266, and possibly others appears to link agonist binding to channel gating
Data also suggest that alpha7 nicotinic acetylcholine receptor (alpha7-nAChR) inhibition or targeting Snail (show SNAI1 Antibodies) may provide a feasible rationale for preventing the progression of HNSCC.
This review discusses the current literature on stroke-induced inflammation and the effects of CHRNA7 modulators on innate immune cells.[Review]
Promoter variant -194C (rs28531779) was significantly associated with schizophrenia, but not associated with P50 suppression or pre-pulse inhibition of the startle reflex. CHRNA7 promoter variants had elevated startle magnitude in pulse-alone trials.
This supports the hypothesis that the antiproliferative activity of SLURP-1 (show SLURP1 Antibodies) is related to 'metabotropic' signaling pathway through alpha7-nAChR, that activates intracellular signaling cascades without opening the receptor channel.
expression of chaperones such as Ric-3 can influence proteins associating with alpha7-nAChRs
14 single nucleotide polymorphisms cause missense mutations of human alpha7 nicotinic receptor exert a different functional impact.
It was concluded that the mechanism of alpha-bungarotoxin antagonism of CHRNA7 is non-competitive, originating from conformational arrest of the binding sites.
The CNV-3956 of CHRNA7 contributed to increased risks and poor prognoses of both COPD (show ARCN1 Antibodies) and lung cancer, and this may be a genetic biomarker of the two diseases.
The results clearly showed that depletion of A7-nAChR (show CHRNA4 Antibodies) suppressed the drug sensitivity of gastric cancer cells to 5-FU treatment
Study explored the microscopic mechanisms underlying the interplay between the channel domains and the coupling interface that affect the channel activity, and generated an allosteric gating model for CHRNA7
Results suggest that a nearly similar TBI-induced decrease in the alpha7 density in the brain of immature and adult animals is found, even with the differences in species, age and experimental procedures.
Lynx1 (show LYNX1 Antibodies) appears to act as a negative modulator of alpha7 nAChR-induced events by inhibiting Src (show SRC Antibodies) activation.
Chronic nicotine exposure up-regulates nAChR (show CHRNA4 Antibodies) activity in developing lung, and that nAChR (show CHRNA4 Antibodies) activity can be further modified by tyrosine phosphorylation.
These results strongly suggest that activating alpha7nAChR can promote diabetic wound healing by suppressing advanced glycation end products-induced TNF-alpha (show TNF Antibodies) production, which may be closely associated with the blockage of NF-kappaB (show NFKB1 Antibodies) activation in macrophages.
It is concluded that inflammation decreases alpha7 nAChR expression in both mitochondria and cell plasma membrane and makes mitochondria more susceptible to apoptosis induction.
Chrna7-deficient mice exhibit sustained attention impairments that are reversed by Chrnb2 (show CHRNB2 Antibodies) activation
The results of this study suggest that activators of nAChRa7 may have therapeutic utility for the treatment of Traumatic brain injury.
Neuroprotective effect of cellular prion protein (PrPC (show PRNP Antibodies)) is related with activation of alpha7 nicotinic acetylcholine receptor (alpha7nAchR)-mediated autophagy flux.
results show that preincubation of 3T3-L1 cells with alpha7nAChR agonist GTS-21 significantly reduces ASP (show C3 Antibodies)-mediated chemokine (show CCL1 Antibodies) MCP-1 (show CPT1B Antibodies) secretion
cAMP-dependent protein kinase (show CDK7 Antibodies) inhibits alpha7 nicotinic receptor activity in layer 1 cortical interneurons through activation of D1/D5 dopamine receptors
we have described the impact of a point mutation in the nicotinic acetylcholine receptor alpha7 on the inflammatory response by the lung to intranasal LPS (show TLR4 Antibodies)
Findings provide evidence to link activation of alpha7 nAChRs to a cAMP rise via AC1 (show HRASLS Antibodies), which defines a new signaling pathway employed by alpha7 nAChRs
Cell surface localization of alpha7-nAChR in the brain of 5xFAD mouse, an animal model of Alzheimer's disease, increased in an age -dependent manner in association with increased accumulation of ABETA (show APP Antibodies) 1-42 in the plasma membrane component.
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.
alpha 7 nicotinic acetylcholine receptor
, cholinergic receptor, nicotinic, alpha polypeptide 7
, neuronal acetylcholine receptor subunit alpha-7
, a7 nicotinic acetylcholine receptor
, alpha 7 neuronal nicotinic acetylcholine receptor
, alpha-7 nicotinic cholinergic receptor subunit
, neuronal acetylcholine receptor protein, alpha-7 chain
, cholinergic receptor nicotinic alpha 7
, C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
, C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
, bungarotoxin alpha
, neuronal nicotinic acetycholine receptor alpha 7
, nicotinic receptor alpha 7 subunit
, nicotinic acetylcholine receptor alpha7
, acetylcholine receptor alpha 7 neural
, alpha7 nicotinic receptor