anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) Antibodies

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. Additionally we are shipping CHRNA7 Proteins (8) and CHRNA7 Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CHRNA7 1139 P36544
CHRNA7 25302 Q05941
CHRNA7 11441 P49582
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Top anti-CHRNA7 Antibodies at antibodies-online.com

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CHRNA7 Antibody Titration: 1.25ug/mlELISA Titer: 1:62500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CHRNA7 Antibody Titration: 2.5ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB CHRNA7 Antibody (N-term) (ABIN657819) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the CHRNA7 antibody detected the CHRNA7 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated EIA, IHC (p)   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Human Rabbit Un-conjugated IHC (fro), IP, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: CHRNA7 Sample Type: Liver Tumor lysates Antibody Dilution: 1.0ug/ml WB Suggested Anti-CHRNA7 antibody Titration: 1 ug/mL Sample Type: Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated EIA, IHC (p) Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with CHRNA7followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated EIA, IHC (fro), IF, WB   0.1 mL Log in to see 6 to 8 Days
$522.50
Details
Chicken Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details

CHRNA7 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CHRNA7 Antibodies

  1. Human Polyclonal CHRNA7 Primary Antibody for IHC (fro), IP - ABIN493153 : Severance, Zhang, Cruz, Pakhlevaniants, Hadley, Amin, Wecker, Reed, Cuevas: The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channels. in Molecular pharmacology 2004 (PubMed)
    Show all 3 references for 493153

  2. Human Polyclonal CHRNA7 Primary Antibody for WB - ABIN657819 : Chernyavsky, Arredondo, Galitovskiy, Qian, Grando: Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases. in American journal of physiology. Cell physiology 2010 (PubMed)
    Show all 2 references for 657819

  3. Cow (Bovine) Polyclonal CHRNA7 Primary Antibody for WB - ABIN2792250 : Avramopoulou, Mamalaki, Tzartos: Soluble, oligomeric, and ligand-binding extracellular domain of the human alpha7 acetylcholine receptor expressed in yeast: replacement of the hydrophobic cysteine loop by the hydrophilic loop of the ACh-binding protein enhances protein solubility. in The Journal of biological chemistry 2004 (PubMed)

  4. Human Polyclonal CHRNA7 Primary Antibody for EIA, IHC (fro) - ABIN113048 : Lips, Brüggmann, Pfeil, Vollerthun, Grando, Kummer: Nicotinic acetylcholine receptors in rat and human placenta. in Placenta 2005 (PubMed)

More Antibodies against CHRNA7 Interaction Partners

Cow (Bovine) Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) interaction partners

  1. We conclude that residues in the M2 segment and flanking regions contribute to the unusual properties of the CHRNA7 receptor

  2. Loop 3 and its docking to the alpha-helix is an important requirement for receptor assembly of the alpha7 nicotinic receptor.

  3. a network of interactions formed by residues Lys (show LYZ Antibodies)-46, Asp (show ASIP Antibodies)-128, Asp (show ASIP Antibodies)-135, Asp (show ASIP Antibodies)-266, and possibly others appears to link agonist binding to channel gating

Human Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) interaction partners

  1. Data (including data from studies conducted using knockout mice and SH-SY5Y cell line) suggest that Wnt/beta-catenin signaling is critical effector of CHRNA7-associated neuroprotection of dopaminergic neurons in substantia nigra; Parkinson's disease appears to develop without this neuroprotection.

  2. Treatment of cells with nicotine induced the mRNA and protein levels of alpha7 nAChR; this could be abrogated by treatment with inhibitors targeting Src (show SRC Antibodies), PI3K (show PIK3CA Antibodies), MEK (show MAP2K1 Antibodies), alpha7 nAChR, CDK4/6 (show CDK4 Antibodies) or a disruptor of the Rb-Raf-1 (show RAF1 Antibodies) interaction.

  3. Activation of alpha7nAChR alleviates Ang II (show AGT Antibodies)-induced vascular smooth muscle cell senescence by promoting NAD(+)-SIRT1 (show SIRT1 Antibodies) pathway.

  4. the role of CHRNA4 (show CHRNA4 Antibodies) and CHRNA7 genetic polymorphisms in moderating auditory target and novelty attentional processing in healthy subjects exposed to the auditory "oddball" P300 (show EP300 Antibodies) paradigm.

  5. We assume an additive effect of haploinsufficiency of ZBTB18 and CHRNA7 in our patient. Assembling the features of our patient and the published patients, we noted that only one of them showed mild anomalies of the corpus callosum.

  6. results demonstrate the anti-inflammatory role of alpha7 nAChR in NK cells and suggest that modulation of its activity in these cells may constitute a novel target for regulation of the immune response.

  7. A7-nAChR (show CHRNA4 Antibodies) may be a key biomarker for assessing the chemosensitivity of gastric cancer cells to taxane.

  8. Data also suggest that alpha7 nicotinic acetylcholine receptor (alpha7-nAChR) inhibition or targeting Snail (show SNAI1 Antibodies) may provide a feasible rationale for preventing the progression of HNSCC.

  9. This review discusses the current literature on stroke-induced inflammation and the effects of CHRNA7 modulators on innate immune cells.[Review]

  10. Promoter variant -194C (rs28531779) was significantly associated with schizophrenia, but not associated with P50 suppression or pre-pulse inhibition of the startle reflex. CHRNA7 promoter variants had elevated startle magnitude in pulse-alone trials.

Pig (Porcine) Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) interaction partners

  1. Results suggest that a nearly similar TBI-induced decrease in the alpha7 density in the brain of immature and adult animals is found, even with the differences in species, age and experimental procedures.

Rhesus Monkey Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) interaction partners

  1. Lynx1 (show LYNX1 Antibodies) appears to act as a negative modulator of alpha7 nAChR-induced events by inhibiting Src (show SRC Antibodies) activation.

  2. Chronic nicotine exposure up-regulates nAChR (show CHRNA4 Antibodies) activity in developing lung, and that nAChR (show CHRNA4 Antibodies) activity can be further modified by tyrosine phosphorylation.

Mouse (Murine) Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) interaction partners

  1. Data (including data from studies conducted using knockout mice and SH-SY5Y cell line) suggest that Wnt/beta-catenin signaling is critical effector of Chrna7-associated neuroprotection of dopaminergic neurons in substantia nigra; Parkinson's disease appears to develop without this neuroprotection.

  2. Activation of alpha7nAChR alleviates Ang II (show AGT Antibodies)-induced vascular smooth muscle cell senescence by promoting NAD(+)-SIRT1 (show SIRT1 Antibodies) pathway.

  3. Study compared the consequences of knocking out the alpha7nAChR on synaptic plasticity in C57/Bl6 and C3H mice, which differ in their basal alpha7nAChR expression levels; homozygous alpha7 deletion in C3H mice, which normally express higher alpha7nAChR levels, resulted in impaired long-term potentiation (LTP (show SCP2 Antibodies)) at hippocampal CA1 (show CA1 Antibodies) synapses, while C3H alpha7 heterozygous mice maintained robust LTP (show SCP2 Antibodies).

  4. Activation of alpha7 nicotinic acetylcholine receptor on mast cells is a mechanism by which nicotine enhances atherosclerosis in ApoE (show APOE Antibodies) knockout mice.

  5. We demonstrated that varenicline upregulates expression of LOX-1 (show OLR1 Antibodies) and CD36 (show CD36 Antibodies) significantly through alpha7 nAChR, thereby promoting oxLDL uptake in macrophages.

  6. These data indicated that alpha7-nAChR caused the inhibition of ASPinduced activation of p38 (show CRK Antibodies) kinase and NFkappa B to inhibit the production of MCP1 (show CCL2 Antibodies) and keratinocytederived chemokine (show CCL1 Antibodies).

  7. These results strongly suggest that activating alpha7nAChR can promote diabetic wound healing by suppressing advanced glycation end products-induced TNF-alpha (show TNF Antibodies) production, which may be closely associated with the blockage of NF-kappaB (show NFKB1 Antibodies) activation in macrophages.

  8. It is concluded that inflammation decreases alpha7 nAChR expression in both mitochondria and cell plasma membrane and makes mitochondria more susceptible to apoptosis induction.

  9. Chrna7-deficient mice exhibit sustained attention impairments that are reversed by Chrnb2 (show CHRNB2 Antibodies) activation

  10. The results of this study suggest that activators of nAChRa7 may have therapeutic utility for the treatment of Traumatic brain injury.

CHRNA7 Antigen Profile

Protein Summary

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with CHRNA7

  • cholinergic receptor, nicotinic, alpha 7 (CHRNA7) antibody
  • cholinergic receptor, nicotinic, alpha 7 (neuronal) (CHRNA7) antibody
  • cholinergic receptor, nicotinic, alpha 7 (neuronal) (Chrna7) antibody
  • cholinergic receptor, nicotinic, alpha polypeptide 7 (Chrna7) antibody
  • Acra7 antibody
  • alpha7 antibody
  • BTX antibody
  • CHRNA7-2 antibody
  • nAChRa7 antibody
  • NARAD antibody

Protein level used designations for CHRNA7

alpha 7 nicotinic acetylcholine receptor , cholinergic receptor, nicotinic, alpha polypeptide 7 , neuronal acetylcholine receptor subunit alpha-7 , a7 nicotinic acetylcholine receptor , alpha 7 neuronal nicotinic acetylcholine receptor , alpha-7 nicotinic cholinergic receptor subunit , neuronal acetylcholine receptor protein, alpha-7 chain , cholinergic receptor nicotinic alpha 7 , C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha) , C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha) , bungarotoxin alpha , neuronal nicotinic acetycholine receptor alpha 7 , nicotinic receptor alpha 7 subunit , nicotinic acetylcholine receptor alpha7 , acetylcholine receptor alpha 7 neural , alpha7 nicotinic receptor , alpha7-nAChR

GENE ID SPECIES
282178 Bos taurus
1139 Homo sapiens
374001 Gallus gallus
100415931 Sus scrofa
25302 Rattus norvegicus
488696 Canis lupus familiaris
574230 Macaca mulatta
11441 Mus musculus
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