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Cholinergic Receptor, Nicotinic, gamma Polypeptide Proteins (CHRNG)

The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. Additionally we are shipping Cholinergic Receptor, Nicotinic, gamma Polypeptide Kits (32) and Cholinergic Receptor, Nicotinic, gamma Polypeptide Antibodies (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHRNG 1146 P07510
Rat CHRNG CHRNG 25753 P18916
CHRNG 11449  
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Top Cholinergic Receptor, Nicotinic, gamma Polypeptide Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details

CHRNG Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for Cholinergic Receptor, Nicotinic, gamma Polypeptide (CHRNG) Interaction Partners

Human Cholinergic Receptor, Nicotinic, gamma Polypeptide (CHRNG) interaction partners

  1. Two siblings with Escobar syndrome caused by homozygous mutations of the CHRNG gene were identified.

  2. Rare cases of congenital arthrogryposis multiplex caused by novel recurrent CHRNG mutations.

  3. No mutations were found in CHRNG, CHRND (show CHRND Proteins) and CHRNA1 (show CHRNA1 Proteins) genes of Indian families with Escobar syndrome.

  4. We did not identify a clear difference in mutation spectrum of the CHRNG gene between lethal form and non-lethal forms of multiple pterygium syndromes

  5. A good correlation was found between the expression of PAX3 (show PAX3 Proteins)/7-FKHR (show FOXO1 Proteins) and AChR, while MyoD1 (show MYOD1 Proteins) was more sensitive but less specific.

  6. CHRNG mutations identified in families with Escobar syndrome show that the trait is a congenital dysmorphology caused by transient inactivation of the neuromuscular endplate.

  7. constructed and characterized four AChR gamma extracellular domain variants

  8. Detection of PAX3 (show PAX3 Proteins)/7-FKHR (show FOXO1 Proteins) fusion gene by one-step RT-PCR is useful in the diagnosis of rhabdomyosarcomas (RMS) and that AChR-gamma is overexpressed in Chinese RMS patients.

Mouse (Murine) Cholinergic Receptor, Nicotinic, gamma Polypeptide (CHRNG) interaction partners

  1. The presence of two new transcript variants (T1 and T2) of chrng expressed in mouse postnatal day 3 and adult skeletal muscles, is reported.

Cholinergic Receptor, Nicotinic, gamma Polypeptide (CHRNG) Protein Profile

Protein Summary

The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.

Gene names and symbols associated with CHRNG

  • cholinergic receptor, nicotinic, gamma (CHRNG)
  • cholinergic receptor, nicotinic, gamma (muscle) (CHRNG)
  • cholinergic receptor, nicotinic, gamma (muscle) (Chrng)
  • cholinergic receptor, nicotinic, gamma (muscle) (chrng)
  • cholinergic receptor, nicotinic, gamma polypeptide (Chrng)
  • Achr-3 protein
  • ACHRG protein
  • Acrg protein

Protein level used designations for CHRNG

acetylcholine receptor subunit gamma , cholinergic receptor, nicotinic, gamma polypeptide , acetylcholine receptor, muscle, gamma subunit , acetylcholine receptor, nicotinic, gamma (muscle) , acetylcholine receptor gamma-subunit , AChR gamma subunit , acetylcholine receptor gamma subunit , chrng variant N1 , chrng variant N2 , nicotinic acetylcholine receptor gamma subunit

GENE ID SPECIES
429151 Gallus gallus
1146 Homo sapiens
486163 Canis lupus familiaris
281689 Bos taurus
25753 Rattus norvegicus
386669 Xenopus laevis
101102965 Ovis aries
11449 Mus musculus
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