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May inhibits BMPs activity by blocking their interaction with their receptors. Additionally we are shipping CHRDL2 Antibodies (42) and CHRDL2 Kits (6) and many more products for this protein.
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Chl, like Chd (show CHRD Proteins), dorsalizes embryos upon overexpression and is cleaved by BMP1 (show BMP1 Proteins); loss-of-function experiments show Chl serves as a BMP antagonist with functions that overlap and are redundant with those of Chd (show CHRD Proteins) in forming the dorsoventral axis.
These results suggest CHRDL2 could serve as a biomarker of poor prognosis in CRC (show CALR Proteins), and provide evidence that CHRDL2 acts as an oncogene (show RAB1A Proteins) in human colorectal cancer
CHL2 expression is restricted to chondrocytes of various developing joint cartilage surfaces and connective tissues in reproductive organs
Differential expression of CHL2 variants was observed during myoblast and osteoblast differentiation, implying a role for this gene in these physiological processes.
CHL2 expression is restricted to chondrocytes of various developing joint cartilage surfaces and connective tissues in reproductive organs.
May inhibits BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.
, chordin-like protein 2
, breast tumor novel factor 1
, chordin-related protein 2
, chordin like 2