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The protein encoded by CSH1 is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. Additionally we are shipping CSH1 Antibodies (130) and CSH1 Kits (31) and many more products for this protein.
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Human CSH1 Protein expressed in HEK-293 Cells - ABIN2180913
Sherwood, Handwerger, McLaurin, Lanner: Amino-acid sequence of human placental lactogen. in Nature: New biology 1971
Show all 2 references for ABIN2180913
Human CSH1 Protein expressed in Human Cells - ABIN2004408
Singleton, Hazen: Differential surface localization and temperature-dependent expression of the Candida albicans CSH1 protein. in Microbiology (Reading, England) 2004
Placental lactogen is expressed but is not translated into protein in breast cancer.
These results indicate that placental lactogen induces CYP2E1 (show CYP2E1 Proteins) expression via PI3-kinase (show PIK3CA Proteins) pathway in human hepatocytes.
Expression of placental lactogen mRNA is increased in plasma of women with placenta previa and invasive placenta.
results are consistent with a pleiotropic effect of placental hGH/CSH genes at the maternal-fetal interface relating to the regulation of fetal growth and the risk of affected maternal metabolism.
Data conclude that members of the C/EBP (show CEBPA Proteins) and Ets (show ETS1 Proteins) families can differentially modulate CS-Benh and CS-Aenh activity.
hPL (show LGALS1 Proteins)-A is involved in the regulation of pancreatic beta cells activity.
Results strongly support a conformationally mediated obligate-ordered prolactin receptor (show PRLR Proteins) binding for each of the three lactogenic hormones: prolactin (show PRL Proteins), growth hormone (show GH1 Proteins), and placental lactogen.
The human growth hormone/chorionic somatomammotropin at chromosome 17 is implicated in regulation of postnatal and intrauterine growth.
Investigation of the GRB2 (show GRB2 Proteins), GRB7 (show GRB7 Proteins), and CSH1 genes as candidates for the Silver-Russell syndrome (SRS (show SMS Proteins)) on chromosome 17q.
a role for CSH1 haploinsufficiency in the etiology of growth retardation
Dysregulation of PL and leptin (show LEP Proteins) in nuclear transfer placentomes could affect cell migration and invasion and subsequently placental metabolism and transfer of nutrients to fetus, leading to increased placental and fetal macrosomia.
Serum free culture conditions significantly enhanced Cyp17 (show CYP17A1 Proteins) and Csh1 (show PRL3D1 Proteins) but not Hsd3b (show HSD3B1 Proteins) expression in trophoblast.
This is the first report to identify the differential regulatory mechanisms of the bCSH1 and bPRP1 genes and indicates that bCSH1 might potentially be the only transcript that is subject to DNA methyltransferase (show DNMT1 Proteins) regulation.
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation\; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity.
, chorionic somatomammotropin A
, chorionic somatomammotropin hormone
, placental lactogen
, chorionic somatomammotropin B
, chorionic somatomammotropin hormone 1 (placental lactogen)
, placental lactogen I
, placental lactogen II