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anti-Choroideremia (Rab Escort Protein 1) (CHM) Antibodies

CHM encodes component A of the RAB geranylgeranyl transferase holoenzyme. Additionally we are shipping CHM Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CHM 1121 P24386
CHM 24942 P37727
CHM 12662  
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Top anti-CHM Antibodies at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB CHM Antibody (Center) (ABIN1881197) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the CHM antibody detected the CHM protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit PE ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 14 Days
$369.79
Details
Rat Goat Un-conjugated WB   600 μg Log in to see 8 to 10 Days
$537.17
Details
Human Rabbit Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$405.17
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 11 to 16 Days
$532.71
Details
Human Rabbit PE ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details

CHM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
,

, , , , ,
Rat (Rattus) ,
,

Mouse (Murine)


Top referenced anti-CHM Antibodies

  1. Human Polyclonal CHM Primary Antibody for WB - ABIN2792245 : Ishiguro, Yamamoto, Fujita, Akasu, Kobayashi, Moriya: Effect of a clinical pathway after laparoscopic surgery for colorectal cancer. in Hepato-gastroenterology 2008 (PubMed)
    Show all 2 references for ABIN2792245

  2. Human Polyclonal CHM Primary Antibody for WB - ABIN1881197 : Renner, Fiebig, Cropp, Weber, Kellner: Progression of retinal pigment epithelial alterations during long-term follow-up in female carriers of choroideremia and report of a novel CHM mutation. in Archives of ophthalmology 2009 (PubMed)

More Antibodies against CHM Interaction Partners

Zebrafish Choroideremia (Rab Escort Protein 1) (CHM) interaction partners

  1. The degenerative phenotype resulting from a null mutation in the zebrafish gene indicates that hair cells and retinal cells require Rab escort protein 1 for survival.

  2. The results of this study propose that in chm(-/-) zebrafish, maternally derived rep allows initial successful development of the embryo, but its gradual loss leads to multisystem disease and invariably to lethality.

Human Choroideremia (Rab Escort Protein 1) (CHM) interaction partners

  1. Six previously reported and five novel CHM mutations were detected in 11 Australian families clinically diagnosed with choroideremia.

  2. The family segregated a REP1 mutation, suggesting choroideremia (CHM).

  3. We report a novel CHM mutation, c.1475_1476insCA, identified by whole-exome sequencing in a family with X-linked CHM initially diagnosed as retinitis pigmentosa.

  4. Sanger sequencing confirmed the mutations in CHM, including four novel (c.558_559delTT, c.964G>T, c.966delA, c.1166+2T>G) and two known (c.7031G>A and c.1584_1587delTGTT) mutations.

  5. the clinical and molecular findings of an Italian family with a new mutation in the choroideremia (CHM) gene, are reported.

  6. While likely an uncommon event, duplication within the CHM gene could be considered as an explanation for CHM cases in which no mutation is found by sequence analysis.

  7. Data found pathogenic DNA variants in the genes RP1 (show STK19 Antibodies), USH2A (show USH2A Antibodies), CNGB3 (show CNGB3 Antibodies), NMNAT1 (show NMNAT1 Antibodies), CHM, and ABCA4 (show ABCA4 Antibodies), responsible for retinitis pigmentosa, Usher syndrome, achromatopsia, Leber congenital amaurosis, choroideremia, or recessive Stargardt/cone-rod dystrophy cases.

  8. These findings demonstrate a novel CHM mutation that emphasizes severe posterior pole carrier phenotypes, age-related changes, and early choroideremia disease.

  9. In Mainland Chinese families, the central visual acuity of male patients with CHM can be affected at an early age (second decade), whereas female CHM carriers may manifest signs and symptoms at a later age (>/= 45 years).

  10. We identified a novel REP1 missense variant (c.1520A>G; p.H507R) associated with CHM that prevents REP1-Rab (show HRB Antibodies) geranylgeranyl transferase interaction.

Mouse (Murine) Choroideremia (Rab Escort Protein 1) (CHM) interaction partners

  1. these results show that PSF (show Il3 Antibodies) can repress the transcriptional activation of VEGF (show VEGFA Antibodies) stimulated by IGF-1 (show IGF1 Antibodies) via recruitment of the Hakai (show CBLL1 Antibodies) complex

  2. Quantitative proteomics reveals dynamic interaction of JNK (show MAPK8 Antibodies) with RNA transport granule proteins Sfpq (show SFPQ Antibodies) and Nono (show NONO Antibodies) during neuronal differentiation

  3. Loss of the Chm/Rep1 gene causes premature accumulation of features of aging in the retinal pigment epithelium.

  4. A protein complex was identified containing PSPC1 (show PSPC1 Antibodies), PSF (show Il3 Antibodies) and LMX1B (show LMX1B Antibodies), suggesting the existence of this complex in mesodiencephalic dopaminergic neurons.

  5. PSF (show Il3 Antibodies) contributes to the stability of a subset of histone genes and that loss of H2AE (show HIST1H2AJ Antibodies) expression in the PSF (show Il3 Antibodies)-deficient thymocytes uniquely contributes to an increase in thymic apoptosis.

  6. analysis indicates PSF (show Il3 Antibodies) within the PER complex recruits SIN3A (show SIN3A Antibodies), a scaffold for assembly of transcriptional inhibitory complexes, and the PER complex thereby rhythmically delivers histone deacetylases to the Per1 (show PER1 Antibodies) promoter, which repress Per1 (show PER1 Antibodies) transcription

  7. Basal and cyclic AMP (show TMPRSS5 Antibodies)-induced Rbp4 (show RBP4 Antibodies) transcription is regulated by a multiprotein complex that is similar to ones that modulate expression of genes of steroid hormone biosynthesis.

  8. identified as a protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies)-binding protein in the cell nucleus

  9. PSPC1 (show PSPC1 Antibodies), NONO (show NONO Antibodies), and SFPQ (show SFPQ Antibodies) form complexes with each other in Sertoli cells and may regulate androgen receptor (show AR Antibodies)-mediated transcriptional activity

  10. Hippocampal mRNA expression of Psf (show Il3 Antibodies) is up-regulated during contextual fear memory formation in both sexes as a specific result of the context/tone-shock association. Changes in splicing factor (show SLU7 Antibodies) expression during LTM formation regulate alternative splicing.

CHM Antigen Profile

Protein Summary

This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia\; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with CHM

  • choroideremia (Rab escort protein 1) (chm) antibody
  • choroideremia (Rab escort protein 1) (CHM) antibody
  • choroideremia (CHM) antibody
  • choroideremia (Rab escort protein 1) (Chm) antibody
  • choroidermia (Chm) antibody
  • splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) (Sfpq) antibody
  • 1110004P21Rik antibody
  • 2810416M14Rik antibody
  • 5730453G22Rik antibody
  • 9030402K04Rik antibody
  • AU021830 antibody
  • CHM antibody
  • D4Ertd314e antibody
  • DKFZp459K2154 antibody
  • DXS540 antibody
  • GGTA antibody
  • Gm12940 antibody
  • HSD-32 antibody
  • MGC68578 antibody
  • OTTMUSG00000009329 antibody
  • PSF antibody
  • Rep-1 antibody
  • REP1 antibody
  • TCD antibody

Protein level used designations for CHM

Rab escort protein 1 , rab proteins geranylgeranyltransferase component A 2 , choroideremia (Rab escort protein 1) , choroideremia , choroideremia protein , rab proteins geranylgeranyltransferase component A 1 , REP-1 , choroideraemia protein homolog , choroideremia protein homolog , choroidermia , rab escort protein 1 , DNA-binding p52/p100 complex, 100 kDa subunit , PTB-associated splicing factor , PTB-associated-splicing factor , polypyrimidine tract-binding protein-associated-splicing factor , splicing factor, proline- and glutamine-rich

GENE ID SPECIES
402935 Danio rerio
465737 Pan troglodytes
480972 Canis lupus familiaris
519552 Bos taurus
694499 Macaca mulatta
100171869 Pongo abelii
399048 Xenopus laevis
1121 Homo sapiens
24942 Rattus norvegicus
12662 Mus musculus
71514 Mus musculus
Selected quality suppliers for anti-CHM (CHM) Antibodies
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