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Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B\; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008].. Additionally we are shipping CHAF1A Proteins (4) and many more products for this protein.
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Human Monoclonal CHAF1A Primary Antibody for ICC, IF - ABIN153013
Smith, Stillman: Immunological characterization of chromatin assembly factor I, a human cell factor required for chromatin assembly during DNA replication in vitro. in The Journal of biological chemistry 1991
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Human Monoclonal CHAF1A Primary Antibody for ICC, IF - ABIN2668347
Hoek, Stillman: Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo. in Proceedings of the National Academy of Sciences of the United States of America 2003
Show all 3 references for ABIN2668347
Human Polyclonal CHAF1A Primary Antibody for ELISA, WB - ABIN1533855
Kaufman, Kobayashi, Kessler, Stillman: The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication. in Cell 1995
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Human Monoclonal CHAF1A Primary Antibody for ELISA, WB - ABIN564324
Doe, Nozawa, Hiruma, Yamada, Matsuki, Nakano, Ogasawara, Nakano, Ikeda, Ikegami, Fujishiro, Kawasaki, Ikeda, Amano, Morimoto, Ogawa, Takamori, Sekigawa, Takasaki: Antibody against chromatin assembly factor-1 is a novel autoantibody specifically recognized in systemic lupus erythematosus. in Lupus 2014
CHAF1A inhibits NEIL1 (show NEIL1 Antibodies) initiated repair in vitro Subsequent restoration of the chaperone-BER complex in cell, presumably after completion of repair, suggests that histone chaperones sequester the repair complex for oxidized bases in non-replicating chromatin, and allow repair when oxidized bases are induced in the genome.
Loss of CAF1 is associated with increased motility and invasive phenotypes seen in transformed cells.
These data suggest that CAF-1 (show CHAF1B Antibodies)- and ASF1A (show ASF1A Antibodies)-H3-H4-dependent deposition of the histone (H3 (show HIST3H3 Antibodies)-H4)2 tetramers is compatible with MMR (show MRC1 Antibodies) and protects the discontinuous daughter strand from unnecessary degradation by MMR (show MRC1 Antibodies) machinery.
Taken together, these results show that CHAF1A contributes to the proliferation of glioblastoma cells and may be developed as a de novo drug target and prognosis biomarker of glioblastoma.
Novel functions for a separable domain of the p150 (show ABL1 Antibodies) protein, regulating protein and DNA interactions at the nucleolus.
The frequency of positive CHAF1A staining in primary tumor mucosa (45.8% of 203 samples) was significantly elevated compared to normal mucosa (18.7% of samples). Increased expression was associated with cancer stage, tumor invasion and histological grade.
Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma (show ARHGEF16 Antibodies).
CAF1 was hijacked by IE2 to facilitate the replication of the HCMV genome, suggesting chromatin assembly plays an important role in herpesviral DNA synthesis, but also provide a model of the virus-induced chromatin instability through CAF1.
CAF (show KAT2B Antibodies)-I-dependent control of degradation of the discontinuous strands during mismatch repair.
these findings suggest an expanded role of p150 (show ABL1 Antibodies) as a SUMO2 (show SUMO2 Antibodies)/3-interacting factor, and raise the intriguing possibility that p150 (show ABL1 Antibodies) plays a role in promoting delivery of SUMO2 (show SUMO2 Antibodies)/3 or SUMO2 (show SUMO2 Antibodies)/3-modified proteins (or both) on chromatin fibers during replication.
CAF-1 (show CNOT7 Antibodies) is an essential guardian of the genome in preimplantation mouse embryos.
the histone chaperone CAF-1 (show CNOT7 Antibodies) to be a novel regulator of somatic cell identity during transcription-factor-induced cell-fate transitions and provide a potential strategy to modulate cellular plasticity in a regenerative setting
Findings suggest that p150 may link the DNA-bound Gfi1 repressor complex to histones enabling modifications required for transcriptional silencing.
This recruitment is strictly dependent on p150CAF-1, the largest subunit of chromatin assembly factor 1 (CAF-1 (show RBBP4 Antibodies)), and its ability to interact with HP1alpha (show CBX5 Antibodies).
during DNA replication, the interaction of HP1 (show CBX5 Antibodies) with p150CAF-1 is essential to promote delivery of HP1 (show CBX5 Antibodies) molecules to heterochromatic sites
findings suggest that CAF-1 (show CNOT7 Antibodies) is required for the maturation of heterochromatin during preimplantation development (show MTA2 Antibodies) and that CAF-1 (show CNOT7 Antibodies) is specifically required for heterochromatin organization in pluripotent embryonic cells
Data show that human CAF-1 (p150) contains two PCNA (show PCNA Antibodies) interaction peptides, and suggest that these peptides are part of the mechanism that enables CAF-1 (show CNOT7 Antibodies) to function behind replication forks without interfering with other PCNA (show PCNA Antibodies)-mediated processes.
Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B\; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995
chromatin assembly factor 1, subunit A (p150)
, chromatin assembly factor 1 subunit A-like
, CAF-1 subunit A
, CAF-I 150 kDa subunit
, CAF-I p150
, chromatin assembly factor 1 subunit A
, chromatin assembly factor I (150 kDa)
, chromatin assembly factor I p150 subunit
, chromatin assembly factor-1p150
, Chromatin assembly factor I p150 subunit
, CAF-I 150 kDa subunit B
, CAF-I p150-B
, Chromatin assembly factor I p150 subunit B
, chromatin assembly factor 1 subunit A-B