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Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B\; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008].. Additionally we are shipping CHAF1A Antibodies (55) and CHAF1A Proteins (4) and many more products for this protein.
Chromatin reassembly during double-strand break repair was dependent on the HIRA histone chaperone that is specific to the replication-independent histone variant H3.3 and on CAF-1 that is specific to the replication-dependent canonical histones H3.1/H3.2.
Data show that the high expression of chromatin assembly factor 1 (show RBBP4 ELISA Kits), subunit A (p150) (CHAF1A) promotes cell proliferation and inhibits cell apoptosis, suggesting that CHAF1A may be developed as a prognosis biomarker and potential therapeutic target of epithelial ovarian cancer (EOC).
CHAF1A inhibits NEIL1 (show NEIL1 ELISA Kits) initiated repair in vitro Subsequent restoration of the chaperone-BER complex in cell, presumably after completion of repair, suggests that histone chaperones sequester the repair complex for oxidized bases in non-replicating chromatin, and allow repair when oxidized bases are induced in the genome.
Loss of CAF1 is associated with increased motility and invasive phenotypes seen in transformed cells.
These data suggest that CAF-1 (show CHAF1B ELISA Kits)- and ASF1A (show ASF1A ELISA Kits)-H3-H4-dependent deposition of the histone (H3 (show HIST3H3 ELISA Kits)-H4)2 tetramers is compatible with MMR (show MRC1 ELISA Kits) and protects the discontinuous daughter strand from unnecessary degradation by MMR (show MRC1 ELISA Kits) machinery.
Taken together, these results show that CHAF1A contributes to the proliferation of glioblastoma cells and may be developed as a de novo drug target and prognosis biomarker of glioblastoma.
Novel functions for a separable domain of the p150 (show ABL1 ELISA Kits) protein, regulating protein and DNA interactions at the nucleolus.
The frequency of positive CHAF1A staining in primary tumor mucosa (45.8% of 203 samples) was significantly elevated compared to normal mucosa (18.7% of samples). Increased expression was associated with cancer stage, tumor invasion and histological grade.
Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma (show ARHGEF16 ELISA Kits).
CAF1 was hijacked by IE2 to facilitate the replication of the HCMV genome, suggesting chromatin assembly plays an important role in herpesviral DNA synthesis, but also provide a model of the virus-induced chromatin instability through CAF1.
CAF-1 (show CNOT7 ELISA Kits) is an essential guardian of the genome in preimplantation mouse embryos.
the histone chaperone CAF-1 (show CNOT7 ELISA Kits) to be a novel regulator of somatic cell identity during transcription-factor-induced cell-fate transitions and provide a potential strategy to modulate cellular plasticity in a regenerative setting
Findings suggest that p150 may link the DNA-bound Gfi1 repressor complex to histones enabling modifications required for transcriptional silencing.
This recruitment is strictly dependent on p150CAF-1, the largest subunit of chromatin assembly factor 1 (CAF-1 (show RBBP4 ELISA Kits)), and its ability to interact with HP1alpha (show CBX5 ELISA Kits).
during DNA replication, the interaction of HP1 (show CBX5 ELISA Kits) with p150CAF-1 is essential to promote delivery of HP1 (show CBX5 ELISA Kits) molecules to heterochromatic sites
findings suggest that CAF-1 (show CNOT7 ELISA Kits) is required for the maturation of heterochromatin during preimplantation development (show MTA2 ELISA Kits) and that CAF-1 (show CNOT7 ELISA Kits) is specifically required for heterochromatin organization in pluripotent embryonic cells
Data show that human CAF-1 (p150) contains two PCNA (show PCNA ELISA Kits) interaction peptides, and suggest that these peptides are part of the mechanism that enables CAF-1 (show CNOT7 ELISA Kits) to function behind replication forks without interfering with other PCNA (show PCNA ELISA Kits)-mediated processes.
Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B\; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995
chromatin assembly factor 1, subunit A (p150)
, chromatin assembly factor 1 subunit A-like
, CAF-1 subunit A
, CAF-I 150 kDa subunit
, CAF-I p150
, chromatin assembly factor 1 subunit A
, chromatin assembly factor I (150 kDa)
, chromatin assembly factor I p150 subunit
, chromatin assembly factor-1p150
, Chromatin assembly factor I p150 subunit
, CAF-I 150 kDa subunit B
, CAF-I p150-B
, Chromatin assembly factor I p150 subunit B
, chromatin assembly factor 1 subunit A-B