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CHMP4B encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family.
Data (including data from studies using transgenic mice) suggest that the process leading to microparticle release from cardiac myocytes involves recruitment of CHMP4B (show CHMP4A Antibodies) protein to the forming microparticle membrane which also contains cBIN1; plasma cBIN1 is reduced in patients with heart failure as compared to control subjects. (CHMP4B (show CHMP4A Antibodies) = charged multivesicular body protein 4B; cBIN1 = cardiac bridging integrator 1 (show BIN1 Antibodies))
homologous domain of human Bro1 (show HMGCR Antibodies) domain-containing proteins, Alix (show PDCD6IP Antibodies) and Brox, binds CHMP4B (show CHMP4A Antibodies) but not STAM2 (show STAM2 Antibodies), despite their high structural similarity
The ESCRT-III subunit CHMP4B (show CHMP4A Antibodies) is a key effector in abscission, whereas its paralogue, CHMP4C (show CHMP4C Antibodies), is a component in the abscission checkpoint that delays abscission until chromatin is cleared from the intercellular bridge.
our results implied that CHMP4B (show CHMP4A Antibodies) could be a promising prognostic biomarker as well as a potential therapeutic target of HCC (show FAM126A Antibodies).
CHMP4B (show CHMP4A Antibodies), through its association with chromatin, may participate in the autophagolysosomal degradation of micronuclei and other extranuclear chromatin.
CHMP4B (show CHMP4A Antibodies) interacts directly with CC2D1A (show CC2D1A Antibodies) and CC2D1B (show CC2D1B Antibodies) with nanomolar affinity by forming a 1:1 complex.
CC2D1A (show CC2D1A Antibodies) interaction with CHMP4B (show CHMP4A Antibodies)/4A blocks HIV-1 budding.
hSnf7-1 and hSnf7-2 are preferentially associated with CHMP2A (show CHMP2A Antibodies) and CHMP2B (show CHMP2B Antibodies), respectively, and regulate the turnover of distinct transmembrane cargos such as neurotransmitter receptors in human neurons.
CHMP4b (show CHMP4A Antibodies) and Alix (show PDCD6IP Antibodies) participate in formation of multivesicular bodies by cooperating with SKD1 (show vps4b Antibodies)
ALIX (show PDCD6IP Antibodies) can have a dramatic effect on HIV-1 release by binding at the CHMP4B (show CHMP4A Antibodies) site; the ability to use ALIX (show PDCD6IP Antibodies) may allow HIV-1 to replicate in cells that express only low levels of Tsg101 (show TSG101 Antibodies)
CHMP4B, through its association with chromatin, may participate in the autophagolysosomal degradation of micronuclei and other extranuclear chromatin.
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
chromatin modifying protein 4B
, SNF7 homolog associated with Alix 1
, Snf7 homologue associated with Alix 1
, charged multivesicular body protein 4b
, chromatin-modifying protein 4b
, vacuolar protein sorting-associated protein 32-2
, vacuolar protein-sorting-associated protein 32-2