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anti-Chromobox Homolog 4 (CBX4) Antibodies

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Additionally we are shipping CBX4 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CBX4 12418 O55187
CBX4 8535 O00257
CBX4 501403  
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Top anti-CBX4 Antibodies at antibodies-online.com

Showing 10 out of 118 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 10 to 12 Days
$427.35
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-CBX4 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB The anti-CBX4 C-term Pab (ABIN389087) is used in Western blot to detect CBX4 in Jurkat cell lysate. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-CBX4 N-term Pab (ABIN389086) is used in Western blot to detect CBX4 in mouse kidney tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IF, WB Western blot analysis of CBX4 in human brain tissue lysate with CBX4 Antibody  at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunofluorescence Microscopy. This anti-hPC2 antibody was used for immunofluorescent imaging of human cells (U2OS). The image reveals the expected discrete nuclear structure that is termed the PcG body corresponding to the known localization of PC2 (see Satijn et al. below). IF was performed after fixation in PBS with 4% PF for 5 min, permeabilization with 0.5% Triton X100-PBS for 5 min, and blocking with 5% milk / 0.2% Tween for 1 h. Primary antibody used at 1:200 in 5% milk / 0.2% Tween for 1 h, secondary antibody for 30 min. All blocking and incubation steps carried out at 37° C. Nuclei were counterstained with Hoechst stain (blue). Data contributed by Luke Hughes-Davies and Rhiannon Jade, Gurdon Institute, Cambridge, UK. Western blotting. Analysis shows the detection of human PC2 in probed lysates using this Affinity Purified anti-hPC2 antibody. The panel on the left shows the blot probed with anti-hPC2. The panel on the right is the same blot reprobed with anti-DYKDDDDK antibody to confirm the presence of DYKDDDDK tagged recombinant PC2 in the lysate. In the left panel the band labeled as hPC2 is DYKDDDDK-tagged transfected hPC2 in 293T cells. The bands labeled with stars are likely endogenous hPC2. In the right panel the band labeled hPC2 is DYKDDDDK-tagged transfected hPC2 in 293T cells. Data contributed by Dr Ari Melnick, Albert Einstein College of Medicine. 0.1 mg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB CBX4 Antibody (N-term)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CBX4 antibody detected the CBX4 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details

CBX4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


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Rat (Rattus)


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Top referenced anti-CBX4 Antibodies

  1. Human Polyclonal CBX4 Primary Antibody for EIA, IF - ABIN1449992 : Simon, Tamkun: Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. in Current opinion in genetics & development 2002 (PubMed)
    Show all 4 references for ABIN1449992

  2. Human Polyclonal CBX4 Primary Antibody for WB - ABIN389087 : Kagey, Melhuish, Wotton: The polycomb protein Pc2 is a SUMO E3. in Cell 2003 (PubMed)
    Show all 3 references for ABIN389087

  3. Human Polyclonal CBX4 Primary Antibody for IHC (p), WB - ABIN389086 : Yang, Sharrocks: The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif. in Molecular and cellular biology 2010 (PubMed)
    Show all 3 references for ABIN389086

  4. Human Polyclonal CBX4 Primary Antibody for EIA, IHC (p) - ABIN357750 : Satijn, Olson, van der Vlag, Hamer, Lambrechts, Masselink, Gunster, Sewalt, van Driel, Otte: Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis. in Molecular and cellular biology 1997 (PubMed)
    Show all 2 references for ABIN357750

  5. Human Polyclonal CBX4 Primary Antibody for EIA, IF - ABIN118002 : Satijn, Gunster, van der Vlag, Hamer, Schul, Alkema, Saurin, Freemont, van Driel, Otte: RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. in Molecular and cellular biology 1997 (PubMed)
    Show all 2 references for ABIN118002

  6. Human Polyclonal CBX4 Primary Antibody for EIA, WB - ABIN357751 : Vincenz, Kerppola: Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

More Antibodies against CBX4 Interaction Partners

Mouse (Murine) Chromobox Homolog 4 (CBX4) interaction partners

  1. The Cbx4 plays a crucial role in the p63 (show CKAP4 Antibodies)-regulated program of epidermal differentiation, maintaining the epithelial identity and proliferative activity in KCs via repression of the selected nonepidermal lineage and cell cycle inhibitor (show CDKN2A Antibodies) genes.

  2. Data indicate an important role of chromobox homolog 4 protein CBX4 in production of high quality oocytes.

  3. Cbx4 is a crucial regulator for the generation and maintenance of the thymic epithelium and, hence, for thymocyte development.

  4. SUMO interaction motif 2 (SIM2 (show SIM2 Antibodies)) is crucial for many of the documented Pc2 functions, which converge on determining its E3 ligase activity.

  5. Our results suggest that Cbx4 functions as a SUMO E3 ligase for Dnmt3a and it might be involved in the functional regulation of DNA methyltransferases by promoting their SUMO modification.

Human Chromobox Homolog 4 (CBX4) interaction partners

  1. Cbx4 is an independent prognostic factor for HCC (show FAM126A Antibodies) patients, and the patients with high Cbx4 expression should receive postoperative TACE (show ADAM17 Antibodies) treatment to improve their survival

  2. our study demonstrated that miR (show MLXIP Antibodies)-195 acts as a tumor suppressor by directly targeting CBX4 in hepatocellular carcinoma

  3. Role of Cbx4 in migration and metastasis of a metastatic hepatocellular carcinoma cell line. Results show that Cbx4 overexpression increases the in vitro vessel formation of vascular endothelial cells in its SUMO interaction motifs-dependent manner.

  4. The presence of CBX4-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.

  5. High cytoplasmic expression of CBX4 is associated with hepatocellular carcinoma.

  6. our findings demonstrate that Cbx4 plays a critical role in tumor angiogenesis by governing HIF-1alpha (show HIF1A Antibodies) protein

  7. ASXL1 (show ASXL1 Antibodies) associates with the PRC2 and loss of ASXL1 (show ASXL1 Antibodies) in vivo collaborates with NRASG12D to promote myeloid leukemogenesis.

  8. High Polycomb (show CBX2 Antibodies) repressive complex protein is associated with mesothelioma.

  9. Pc2 (show KRT6B Antibodies), methylation controls the protein's interaction with two distinct ncRNAs, TUG1 and NEAT2, which results in the exclusive subnuclear localization of methylated and unmethylated Pc2 (show KRT6B Antibodies) in Polycomb (show CBX2 Antibodies) bodies and interchromatin granules, respectively.

  10. the hPc2 (show ELAC2 Antibodies)-induced SUMOylation of alpha-synuclein (show SNCA Antibodies) could function as a cytoprotector by increasing alpha-synuclein (show SNCA Antibodies) aggregate formation within fibroblast cells.

CBX4 Antigen Profile

Protein Summary

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Gene names and symbols associated with CBX4

  • chromobox homolog 4 (CBX4) antibody
  • chromobox 4 (Cbx4) antibody
  • chromobox homolog 4 (cbx4) antibody
  • chromobox homolog 4 (Cbx4) antibody
  • chromobox homolog 4 (Pc class homolog, Drosophila) (cbx4) antibody
  • cbx4-a antibody
  • im:6911625 antibody
  • MPc2 antibody
  • NBP16 antibody
  • PC2 antibody
  • XPolycomb antibody
  • zgc:158588 antibody

Protein level used designations for CBX4

chromobox homolog 4 , E3 SUMO-protein ligase CBX4 , chromobox protein homolog 4 , polycomb 2 homolog , NS5ATP1-binding protein 16 , Pc class 2 homolog , chromobox homolog 4 (Pc class homolog, Drosophila) , chromobox homolog 4 (Pc class homolog) , chromobox homolog 4 (Polycomb) , chromobox protein (CHCB3) , chromobox-like protein 4 , polycomb 2

GENE ID SPECIES
744720 Pan troglodytes
12418 Mus musculus
8535 Homo sapiens
394294 Xenopus laevis
395354 Gallus gallus
608556 Canis lupus familiaris
767865 Bos taurus
501403 Rattus norvegicus
573110 Danio rerio
Selected quality suppliers for anti-CBX4 (CBX4) Antibodies
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