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E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Additionally we are shipping CBX4 Proteins (3) and many more products for this protein.
Showing 10 out of 119 products:
Human Polyclonal CBX4 Primary Antibody for EIA, IF - ABIN1449992
Simon, Tamkun: Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. in Current opinion in genetics & development 2002
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Human Polyclonal CBX4 Primary Antibody for WB - ABIN389087
Kagey, Melhuish, Wotton: The polycomb protein Pc2 is a SUMO E3. in Cell 2003
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Human Polyclonal CBX4 Primary Antibody for IHC (p), WB - ABIN389086
Yang, Sharrocks: The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif. in Molecular and cellular biology 2010
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Human Polyclonal CBX4 Primary Antibody for ICC, IF - ABIN4288456
Ismail, Gagné, Caron, McDonald, Xu, Masson, Poirier, Hendzel: CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage. in Nucleic acids research 2012
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Human Polyclonal CBX4 Primary Antibody for EIA, IF - ABIN118002
Satijn, Olson, van der Vlag, Hamer, Lambrechts, Masselink, Gunster, Sewalt, van Driel, Otte: Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis. in Molecular and cellular biology 1997
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Human Polyclonal CBX4 Primary Antibody for WB - ABIN2559520
Han, Wang, Li, Dong, Zhang, Yan: HIF-1α SUMOylation affects the stability and transcriptional activity of HIF-1α in human lens epithelial cells. in Graefe's archive for clinical and experimental ophthalmology 2015
Human Polyclonal CBX4 Primary Antibody for EIA, WB - ABIN357751
Vincenz, Kerppola: Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences. in Proceedings of the National Academy of Sciences of the United States of America 2008
The Cbx4 plays a crucial role in the p63 (show CKAP4 Antibodies)-regulated program of epidermal differentiation, maintaining the epithelial identity and proliferative activity in KCs via repression of the selected nonepidermal lineage and cell cycle inhibitor (show CDKN2A Antibodies) genes.
Data indicate an important role of chromobox homolog 4 protein CBX4 in production of high quality oocytes.
Cbx4 is a crucial regulator for the generation and maintenance of the thymic epithelium and, hence, for thymocyte development.
SUMO interaction motif 2 (SIM2 (show SIM2 Antibodies)) is crucial for many of the documented Pc2 functions, which converge on determining its E3 ligase activity.
Our results suggest that Cbx4 functions as a SUMO E3 ligase for Dnmt3a and it might be involved in the functional regulation of DNA methyltransferases by promoting their SUMO modification.
Cbx4 is an independent prognostic factor for HCC (show FAM126A Antibodies) patients, and the patients with high Cbx4 expression should receive postoperative TACE (show ADAM17 Antibodies) treatment to improve their survival
our study demonstrated that miR (show MLXIP Antibodies)-195 acts as a tumor suppressor by directly targeting CBX4 in hepatocellular carcinoma
Role of Cbx4 in migration and metastasis of a metastatic hepatocellular carcinoma cell line. Results show that Cbx4 overexpression increases the in vitro vessel formation of vascular endothelial cells in its SUMO interaction motifs-dependent manner.
The presence of CBX4-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.
High cytoplasmic expression of CBX4 is associated with hepatocellular carcinoma.
our findings demonstrate that Cbx4 plays a critical role in tumor angiogenesis by governing HIF-1alpha (show HIF1A Antibodies) protein
ASXL1 (show ASXL1 Antibodies) associates with the PRC2 and loss of ASXL1 (show ASXL1 Antibodies) in vivo collaborates with NRASG12D to promote myeloid leukemogenesis.
High Polycomb (show CBX2 Antibodies) repressive complex protein is associated with mesothelioma.
Pc2 (show KRT6B Antibodies), methylation controls the protein's interaction with two distinct ncRNAs, TUG1 and NEAT2, which results in the exclusive subnuclear localization of methylated and unmethylated Pc2 (show KRT6B Antibodies) in Polycomb (show CBX2 Antibodies) bodies and interchromatin granules, respectively.
the hPc2 (show ELAC2 Antibodies)-induced SUMOylation of alpha-synuclein (show SNCA Antibodies) could function as a cytoprotector by increasing alpha-synuclein (show SNCA Antibodies) aggregate formation within fibroblast cells.
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
chromobox homolog 4
, E3 SUMO-protein ligase CBX4
, chromobox protein homolog 4
, polycomb 2 homolog
, NS5ATP1-binding protein 16
, Pc class 2 homolog
, chromobox homolog 4 (Pc class homolog, Drosophila)
, chromobox homolog 4 (Pc class homolog)
, chromobox homolog 4 (Polycomb)
, chromobox protein (CHCB3)
, chromobox-like protein 4
, polycomb 2