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human homolog interacts with Ring1 and localizes to nuclear Polycomb bodies [RGD, Feb 2006].. Additionally we are shipping CBX7 Antibodies (14) and CBX7 Kits (4) and many more products for this protein.
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CD4 (show CD4 Proteins)(+) T cells express Cbx7; the latter prevents FasL (show FASL Proteins) expression and the activation-induced CD4 (show CD4 Proteins)(+) T cell apoptosis.
Threonine 118 is a novel phosphorylation site of mouse Cbx7. Cbx7T118 phosphorylation moderately enhances repression of its target gene p16.
Although the genomic localization of the Cbx7- and RYBP (show RYBP Proteins)-containing PRC1 (show PRC1 Proteins) complexes overlaps in certain genes, it can also be mutually exclusive.
MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation.
These data suggest that CBX7 is a tumor suppressor and that its loss plays a key role in the pathogenesis of cancer.
controls cellular lifespan through regulation of both the p16(Ink4a)/Rb and the Arf/p53 (show TP53 Proteins) pathways
CBX7 is a chromobox protein causally linked to cancer development
the miR (show MLXIP Proteins)-9 family of microRNAs (miRNAS) downregulates the expression of CBX7. In turn, CBX7 represses miR (show MLXIP Proteins)-9-1 and miR (show MLXIP Proteins)-9-2 as part of a regulatory negative feedback loop.
these results suggest that the retention of CBX7 expression may play a role in the modulation of chemosensitivity of lung cancer patients to the treatment with irinotecan and etoposide
Data show that polycomb (show CBX2 Proteins)-group proteins BMI1 (show BMI1 Proteins), PHC3 (show PHC3 Proteins), CBX6 (show CBX6 Proteins) and CBX7 expression was significantly increased during imatinib treatment.
Cbx7 is downregulated in CCs (show CCS Proteins), and Cbx7 expression-low tumors correlated with lymph metastasis and poor overall survival of CC patients.
CBX7/HMGA1b (show HMGA1 Proteins)/NF-kappaB (show NFKB1 Proteins) could take part in the same transcriptional mechanism that finally leads to the regulation of SPP1 (show SPP1 Proteins) gene expression in papillary thyroid carcinoma.
Aberrantly expressed miR (show MLXIP Proteins)-9 contributes to T24 cells invasion, partly through directly down-regulating CBX7 protein expression in bladder transitional cell carcinoma
Results suggest that the loss of CBX7 expression might play a critical role in advanced stages of carcinogenesis by deregulating the expression of specific effector genes.
CBX7-mediated epigenetic induction of DKK-1 (show DKK1 Proteins) is crucial for the inhibition of breast tumorigenicity, suggesting that CBX7 could be a potential tumor suppressor in breast cancer.
we showed for the first time that CBX7 was associated with a decreased prognosis for clear cell adenocarcinoma of the ovary
cbx7 expression was significantly downregulated in multiple human cancer tissues.
human homolog interacts with Ring1 and localizes to nuclear Polycomb bodies
chromobox homolog 7
, chromobox protein homolog 7
, chromobox 7