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anti-Chromobox Homolog 8 (CBX8) Antibodies

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Additionally we are shipping CBX8 Kits (4) and CBX8 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CBX8 30951 Q9QXV1
CBX8 57332 Q9HC52
CBX8 303731  
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Top anti-CBX8 Antibodies at antibodies-online.com

Showing 10 out of 127 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-CBX8 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: COLO205 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CBX8 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB CBX8 Antibody (Center) western blot analysis in mouse liver tissue lysates (35µg/lane).This demonstrates the CBX8 antibody detected the CBX8 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CBX8 Antibody Titration: 2.5ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate WB Suggested Anti-CBX8  Antibody Titration: 2.5 µg/mL ELISA Titer: 1:1562500  Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-CBX8 C-term Pab (ABIN389089) is used in Western blot to detect CBX8 in mouse kidney tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB ABIN334369 (0.1µg/ml) staining of K562 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated FACS, ELISA, WB 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Mouse Rabbit Un-conjugated WB CBX8 Antibody (Center) (ABIN658577) western blot analysis in mouse liver tissue lysates (35 µg/lane). This demonstrates the CBX8 antibody detected the CBX8 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details

CBX8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-CBX8 Antibodies

  1. Human Polyclonal CBX8 Primary Antibody for EIA, WB - ABIN951075 : Obuse, Yang, Nozaki, Goto, Okazaki, Yoda et al.: Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the ... in Genes to cells : devoted to molecular & cellular mechanisms 2004 (PubMed)
    Show all 5 references for ABIN951075

  2. Human Polyclonal CBX8 Primary Antibody for IHC (p), WB - ABIN389089 : Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003 (PubMed)
    Show all 3 references for ABIN389089

  3. Human Polyclonal CBX8 Primary Antibody for EIA, IHC (p) - ABIN357753 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 3 references for ABIN357753

  4. Mouse (Murine) Polyclonal CBX8 Primary Antibody for WB - ABIN658577 : Dietrich, Bracken, Trinh, Schjerling, Koseki, Rappsilber, Helin, Hansen: Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. in The EMBO journal 2007 (PubMed)
    Show all 3 references for ABIN658577

  5. Cow (Bovine) Polyclonal CBX8 Primary Antibody for WB - ABIN2781105 : Bárdos, Saurin, Tissot, Duprez, Freemont: HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties. in The Journal of biological chemistry 2000 (PubMed)

More Antibodies against CBX8 Interaction Partners

Mouse (Murine) Chromobox Homolog 8 (CBX8) interaction partners

  1. Cbx8 is upregulated and recruited to activated genes during embryonic stem cell differentiation.

  2. CBX8 plays an essential role in MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) transcriptional regulation and leukemogenesis.

  3. Pcl2 (show MTF2 Antibodies)-PRC2 facilitates both PRC2 recruitment to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells.

  4. Huntingtin (show HTT Antibodies) is a novel stimulator of polycomb (show CBX2 Antibodies) repressive complex 2.

Human Chromobox Homolog 8 (CBX8) interaction partners

  1. These data suggest that CBX8 modulates SIPS through the RB-E2F1 pathway in CML cells and provide important insight into its application in CML treatment.

  2. Low CBX8 expression was associated with distant metastasis in colorectal cancer.

  3. CBX8 might emerge as an oncogene (show RAB1A Antibodies) for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy.

  4. The presence of CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.

  5. Interaction with CBX8 precludes AF9 (show MLLT3 Antibodies)-DOT1L (show DOT1L Antibodies) binding.

  6. CBX8 cooperated with SIRT1 (show SIRT1 Antibodies) for suppressing p53 (show TP53 Antibodies) acetylation induced by Sirtinol and etoposide/TSA (show PRDX2 Antibodies). Upon ectopic expression, CBX8 or SIRT1 (show SIRT1 Antibodies) repressed the expression of p21(WAF1 (show CDKN1A Antibodies)) by inhibiting p53 (show TP53 Antibodies) binding to the promoter.

  7. CBX8 plays an essential role in MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) transcriptional regulation and leukemogenesis.

  8. CBX8 is an essential component of one of the polycomb (show CBX2 Antibodies) repressive complexes, which directly regulate the expression of numerous target genes, including the INK4A-ARF (show CDKN2A Antibodies) locus, involved in cell-fate decisions.

CBX8 Antigen Profile

Protein Summary

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Gene names and symbols associated with CBX8

  • chromobox homolog 8 (cbx8) antibody
  • chromobox homolog 8 (CBX8) antibody
  • chromobox 8 (Cbx8) antibody
  • chromobox homolog 8 (Cbx8) antibody
  • chromobox homolog 8a (Pc class homolog, Drosophila) (cbx8a) antibody
  • cbx8 antibody
  • MGC147589 antibody
  • PC3 antibody
  • RC1 antibody

Protein level used designations for CBX8

chromobox homolog 8 , chromobox protein homolog 8 , mPc3 , polycomb 3 homolog , Pc class 3 homolog , chromobox homolog 8 (Pc class homolog, Drosophila) , polycomb 3 , rectachrome 1 , chromobox-like protein 8 , chromobox homolog 8 (Pc class homolog) , chromobox homolog 8a

GENE ID SPECIES
779897 Xenopus (Silurana) tropicalis
100604409 Nomascus leucogenys
30951 Mus musculus
57332 Homo sapiens
608591 Canis lupus familiaris
506458 Bos taurus
303731 Rattus norvegicus
496172 Xenopus laevis
100514536 Sus scrofa
422084 Gallus gallus
100150672 Danio rerio
Selected quality suppliers for anti-CBX8 (CBX8) Antibodies
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