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Chromobox Homolog 8 Proteins (CBX8)

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Additionally we are shipping CBX8 Antibodies (127) and CBX8 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CBX8 30951 Q9QXV1
CBX8 57332 Q9HC52
Rat CBX8 CBX8 303731  
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Top CBX8 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

CBX8 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Chromobox Homolog 8 (CBX8) Interaction Partners

Mouse (Murine) Chromobox Homolog 8 (CBX8) interaction partners

  1. Cbx8 is upregulated and recruited to activated genes during embryonic stem cell differentiation.

  2. CBX8 plays an essential role in MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) transcriptional regulation and leukemogenesis.

  3. Pcl2 (show MTF2 Proteins)-PRC2 facilitates both PRC2 recruitment to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells.

  4. Huntingtin (show HTT Proteins) is a novel stimulator of polycomb (show CBX2 Proteins) repressive complex 2.

Human Chromobox Homolog 8 (CBX8) interaction partners

  1. These data suggest that CBX8 modulates SIPS through the RB-E2F1 pathway in CML cells and provide important insight into its application in CML treatment.

  2. Low CBX8 expression was associated with distant metastasis in colorectal cancer.

  3. CBX8 might emerge as an oncogene (show RAB1A Proteins) for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy.

  4. The presence of CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.

  5. Interaction with CBX8 precludes AF9 (show MLLT3 Proteins)-DOT1L (show DOT1L Proteins) binding.

  6. CBX8 cooperated with SIRT1 (show SIRT1 Proteins) for suppressing p53 (show TP53 Proteins) acetylation induced by Sirtinol and etoposide/TSA (show PRDX2 Proteins). Upon ectopic expression, CBX8 or SIRT1 (show SIRT1 Proteins) repressed the expression of p21(WAF1 (show CDKN1A Proteins)) by inhibiting p53 (show TP53 Proteins) binding to the promoter.

  7. CBX8 plays an essential role in MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) transcriptional regulation and leukemogenesis.

  8. CBX8 is an essential component of one of the polycomb repressive complexes, which directly regulate the expression of numerous target genes, including the INK4A-ARF locus, involved in cell-fate decisions.

CBX8 Protein Profile

Protein Summary

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Gene names and symbols associated with Chromobox Homolog 8 Proteins (CBX8)

  • chromobox homolog 8 (cbx8)
  • chromobox homolog 8 (CBX8)
  • chromobox 8 (Cbx8)
  • chromobox homolog 8 (Cbx8)
  • chromobox homolog 8a (Pc class homolog, Drosophila) (cbx8a)
  • cbx8 protein
  • MGC147589 protein
  • PC3 protein
  • RC1 protein

Protein level used designations for Chromobox Homolog 8 Proteins (CBX8)

chromobox homolog 8 , chromobox protein homolog 8 , mPc3 , polycomb 3 homolog , Pc class 3 homolog , chromobox homolog 8 (Pc class homolog, Drosophila) , polycomb 3 , rectachrome 1 , chromobox-like protein 8 , chromobox homolog 8 (Pc class homolog) , chromobox homolog 8a

GENE ID SPECIES
779897 Xenopus (Silurana) tropicalis
100604409 Nomascus leucogenys
30951 Mus musculus
57332 Homo sapiens
608591 Canis lupus familiaris
506458 Bos taurus
303731 Rattus norvegicus
496172 Xenopus laevis
100514536 Sus scrofa
422084 Gallus gallus
100150672 Danio rerio
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