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The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. Additionally we are shipping CHD2 Kits (3) and and many more products for this protein.
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Dog (Canine) Polyclonal CHD2 Primary Antibody for WB - ABIN2775752
Feys, Poppe, De Preter, Van Roy, Verhasselt, De Paepe, De Paepe, Speleman: A detailed inventory of DNA copy number alterations in four commonly used Hodgkin's lymphoma cell lines. in Haematologica 2007
Results indicate a PARP1 (show PARP1 Antibodies)-dependent mechanism that regulates non-homologous end-joining through localized chromatin expansion and deposition of the histone variant H3.3 by CHD2 at DNA breaks promoting DNA repair.
CHD2 mutations are responsible in rare cases for generalized epilepsy with myoclonic-atonic seizures.
CHD2 is a cancer driver and has a role as chromatin remodeler in chronic lymphocytic leukemia.
CHD2 mutation is the first identified cause of the archetypal generalized photosensitive epilepsy syndrome
CHD1 (show CHD1 Antibodies) and CHD2 act as positive regulators of HIV-1 gene expression.
The phenotypic spectrum of CHD2 encephalopathy has distinctive features of myoclonic epilepsy with marked photosensitivity.
Human CHD2 is a chromatin assembly ATPase (show DNAH8 Antibodies) regulated by its chromatin- and DNA-binding domains.
Our findings suggest that CHD2 mutations are important in the etiological spectrum of Lennox-Gastaut syndrome.
Genetic variants of BCL2 (show BCL2 Antibodies), GNAO1 (show GNAO1 Antibodies), and CHD2 are associated with non-obstructive azoospermia risk.
De novo loss-of-function mutations in CHD2 are a cause of epileptic encephalopathy with generalized seizures.
inactivation of CHD2 during neurogenesis might contribute to abnormal neurodevelopment
The data indicated that MyoD determines cell fate and facilitates differentiation- dependent gene expression through Chd2-dependent deposition of H3.3 at myogenic loci prior to differentiation.
Study present evidence that the Chd2 mutant cells are defective in their ability to repair DNA damage induced by ionizing and ultraviolet radiation.
Our results demonstrate that mutation of Chd2 dramatically affects mammalian development and long-term survival.
Chd2 heterozygous mutant mice exhibit increased extramedullary hematopoiesis and susceptibility to lymphomas.
Chd2-mutant mice present with glomerulopathy, proteinuria, and significantly impaired kidney function.
The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
chromodomain helicase DNA binding protein 2
, ATP-dependent helicase CHD2
, chromodomain-helicase-DNA-binding protein 2