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The product of CHD4 belongs to the SNF2/RAD54 helicase family. Additionally we are shipping CHD4 Antibodies (79) and CHD4 Proteins (6) and many more products for this protein.
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CHD4 plays a pivotal role in chemoresistance and the maintenance of stemness in liver cancer stem cells and is therefore a good target for the eradication of hepatocellular carcinoma.
Acetyltransferase p300 (show EP300 ELISA Kits) collaborates with chromodomain helicase DNA-binding protein 4 (CHD4) to facilitate DNA double-strand break repair
Specifically, methyl-CpG-binding domain protein 2 (MBD2 (show MBD2 ELISA Kits)) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (show DPEP1 ELISA Kits) domain and MBD2 (show DPEP2 ELISA Kits) C-terminus.
these data build on our understanding of how CHD4-NuRD acts to regulate gene expression and participates in the DNA-damage response.
CHD4 depletion modulates expression of acute myeloid leukemia (show BCL11A ELISA Kits) cell genes that regulate tumor formation in vivo and colony formation in vitro.
Also discovered a novel causative role for CHD4, a helicase involved in the histone deacetylase (show HDAC1 ELISA Kits) complex that is associated with poor clinical outcome.
CHD4 modulates therapeutic response in BRCA2 (show BRCA2 ELISA Kits) mutant cancer cells.
Endogenous Mta1 (show MTA1 ELISA Kits)/2 forms a complex with chromodomain helicase (Chd)4, histone deacetylases (Hdac)1 (show HDAC1 ELISA Kits)/2, RbAp46 (show RBBP7 ELISA Kits)/48, and Mbd3 (show MBD3 ELISA Kits) in rat cerebellum
CHD4 and HDAC1 (show HDAC1 ELISA Kits) occupy the promoters of several of these hypermethylated tumor suppressor genes and physically and functionally interact to maintain their silencing.
repressive functions of MBD2 (show DPEP2 ELISA Kits)-containing NuRD complexes are dependent on cooperative interactions between the major domains of CHD4 with histones and DNA and on binding of methylated DNA by MBD2 (show DPEP2 ELISA Kits)
CHD4 allows cells to undertake lineage commitment in vivo by modulating the frequency with which lineage-specification genes are expressed.
Chromatin immunoprecipitation assays showed that CHD4-containing NuRD complexes directly bound the promoters of these genes in endothelial cells
Chd4, interacting with Hdac1 (show HDAC1 ELISA Kits)/2, cooperates with its related proteins Kap1 (show TRIM28 ELISA Kits) and Cbx1 (show CBX1 ELISA Kits) to bind at -207/-148 of the Sox9 (show SOX9 ELISA Kits) promoter.
NuRD negatively regulates TIP5 expression, thereby inhibiting ribosomal DNA (rDNA) methylation and maintaining demethylation state of rDNA promoters.
The chromodomain helicase DNA-binding protein 4 (Chd4) is a critical interaction partner of Ezh2 (show EZH2 ELISA Kits) required specifically for Polycomb (show CBX2 ELISA Kits) group (PcG)-mediated suppression of the key astrogenic marker gene GFAP (show GFAP ELISA Kits).
Gata3 (show GATA3 ELISA Kits)/Chd4 forms functionally distinct complexes, which mediate both positive and negative gene regulation to facilitate Th2 cell differentiation.
In this study, we demonstrate that Mi2beta is required for gamma-globin gene silencing during adult definitive erythropoiesis
Concomitant deletion of Chd4 and Brg1 (show SMARCA4 ELISA Kits) rescued vascular abnormalities seen in Brg1 (show SMARCA4 ELISA Kits) mutant yolk sacs (show SACS ELISA Kits) to the same extent as LiCl treatment.
activity of the Mi-2beta nucleosome-remodeling and histone-deacetylase (show HDAC1 ELISA Kits) (NuRD) complex was controlled by the Ikaros (show IKZF1 ELISA Kits) family of lymphoid lineage-determining proteins.
CHD4 functions as a MAP required for MT stabilization and is involved in generating spindle bipolarity.
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
chromodomain helicase DNA binding protein 4
, chromodomain-helicase-DNA-binding protein 4
, ATP-dependent helicase CHD4
, Mi-2 autoantigen 218 kDa protein
, Mi-2 autoantigen
, Mi-2 beta