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The product of CHD4 belongs to the SNF2/RAD54 helicase family. Additionally we are shipping CHD4 Proteins (8) and CHD4 Kits (5) and many more products for this protein.
Showing 10 out of 78 products:
Human Monoclonal CHD4 Primary Antibody for WB - ABIN4948202
Li, Zhang, Yu, Chen, Gui, Liang, Wang, Sun, Yang, Zhang, Shi, Li, Shang: ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. in The EMBO journal 2009
Show all 5 references for 4948202
Human Polyclonal CHD4 Primary Antibody for ICC, IF - ABIN2668534
Curtis, Griffin: The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. in Molecular and cellular biology 2012
Show all 4 references for 2668534
Human Monoclonal CHD4 Primary Antibody for IHC (p), ELISA - ABIN560357
Nishibuchi, Shibata, Hayakawa, Hayakawa, Ohtani, Sinmyozu, Tagami, Nakayama: Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex. in The Journal of biological chemistry 2014
Fruit Fly (Drosophila melanogaster) Monoclonal CHD4 Primary Antibody for IP, WB - ABIN2668526
Murawska, Kunert, van Vugt, Längst, Kremmer, Logie, Brehm: dCHD3, a novel ATP-dependent chromatin remodeler associated with sites of active transcription. in Molecular and cellular biology 2008
Human Polyclonal CHD4 Primary Antibody for IP, PLA - ABIN252858
Ma, Lin, Bartolomei, Schultz: Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. in Biology of reproduction 2010
Human Polyclonal CHD4 Primary Antibody for IF, IHC - ABIN1533894
Schmidt, Schreiber: Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. in Biochemistry 1999
Cow (Bovine) Polyclonal CHD4 Primary Antibody for WB - ABIN2775753
Sillibourne, Delaval, Redick, Sinha, Doxsey: Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity. in Molecular biology of the cell 2007
Human Polyclonal CHD4 Primary Antibody for IP, WB - ABIN252857
Shakya, Kang, Chumley, Williams, Tantin: Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states. in The Journal of biological chemistry 2011
Human Polyclonal CHD4 Primary Antibody for IP, WB - ABIN252859
Gu, Hu, Ebrahem, Crabb, Mahfouz, Radivoyevitch, Crabb, Saunthararajah: Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy. in The Journal of biological chemistry 2014
The findings identify that CHD4 deficiency preferentially impairs cell survival via increasing the level of p21 (show CDKN1A Antibodies).
Mutation in CHD4 gene is associated with congenital heart defects.
this work identifies CHD4 as an epigenetic coregulator of PAX3 (show PAX3 Antibodies)-FOXO1 (show FOXO1 Antibodies) activity, providing rational evidence for CHD4 as a potential therapeutic target in alveolar rhabdomyosarcoma.
CHD4 recruits repressive chromatin proteins to sites of DNA damage repair, including DNA methyltransferases where it imposes de novo DNA methylation (show HELLS Antibodies). At TSGs, CHD4 retention helps maintain DNA hypermethylation-associated transcriptional silencing.
this study identifies the Chd4-Tbx3 (show TBX3 Antibodies) axis in controlling ESC fate and a role of H2A.Z (show H2AFZ Antibodies) in maintaining the stability of Chd4 proteins.
report provides evidence for the role of CHD4 in human development and expands an increasingly recognized group of Mendelian disorders involving chromatin remodeling and modification
complex lacking CHD4 that has HDAC (show HDAC3 Antibodies) activity can exist as a stable species. The addition of recombinant CHD4 to this nucleosome deacetylase complex reconstitutes a NuRD complex with nucleosome remodeling activity.
CHD4 plays a pivotal role in chemoresistance and the maintenance of stemness in liver cancer stem cells and is therefore a good target for the eradication of hepatocellular carcinoma.
Acetyltransferase p300 (show EP300 Antibodies) collaborates with chromodomain helicase DNA-binding protein 4 (CHD4) to facilitate DNA double-strand break repair
Specifically, methyl-CpG-binding domain protein 2 (MBD2 (show MBD2 Antibodies)) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (show DPEP1 Antibodies) domain and MBD2 (show DPEP2 Antibodies) C-terminus.
Chd4 mutant embryos died before birth and exhibited severe edema, blood-filled lymphatics, and liver hemorrhage. CHD4-deficient embryos developed normal lymphovenous (LV) valves, which regulate the return of lymph to the blood circulation; however, these valves lacked the fibrin-rich thrombi that prevent blood from entering the lymphatic system.
This secreted effector, toxoplasma inhibitor of STAT1 (show STAT1 Antibodies)-dependent transcription (TgIST), translocates to the host cell nucleus, where it recruits mouse Mi-2/NuRD to STAT1 (show STAT1 Antibodies)-dependent promoters, resulting in altered chromatin and blocked transcription.
this study shows that the chromatin remodeler Mi-2beta controls epidermal homeostasis by regulating the genes involved in keratinocyte and immune-cell activation to maintain an inactive state
preservation of the identity of the two striated (show NSDHL Antibodies) muscle types depends on epigenetic repression of the alternate lineage gene program by the chromatin remodeling complex Chd4/NuRD.
CHD4 depletion modulates expression of acute myeloid leukemia (show BCL11A Antibodies) cell genes that regulate tumor formation in vivo and colony formation in vitro.
CHD4 allows cells to undertake lineage commitment in vivo by modulating the frequency with which lineage-specification genes are expressed.
Chromatin immunoprecipitation assays showed that CHD4-containing NuRD complexes directly bound the promoters of these genes in endothelial cells
Chd4, interacting with Hdac1 (show HDAC1 Antibodies)/2, cooperates with its related proteins Kap1 (show TRIM28 Antibodies) and Cbx1 (show CBX1 Antibodies) to bind at -207/-148 of the Sox9 (show SOX9 Antibodies) promoter.
NuRD negatively regulates TIP5 (show BAZ2A Antibodies) expression, thereby inhibiting ribosomal DNA (rDNA) methylation and maintaining demethylation state of rDNA promoters.
CHD4 functions as a MAP required for MT stabilization and is involved in generating spindle bipolarity.
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
chromodomain helicase DNA binding protein 4
, chromodomain-helicase-DNA-binding protein 4
, ATP-dependent helicase CHD4
, Mi-2 autoantigen 218 kDa protein
, Mi-2 autoantigen
, Mi-2 beta