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The product of CHD4 belongs to the SNF2/RAD54 helicase family. Additionally we are shipping CHD4 Antibodies (80) and CHD4 Kits (5) and many more products for this protein.
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report provides evidence for the role of CHD4 in human development and expands an increasingly recognized group of Mendelian disorders involving chromatin remodeling and modification
complex lacking CHD4 that has HDAC (show HDAC3 Proteins) activity can exist as a stable species. The addition of recombinant CHD4 to this nucleosome deacetylase complex reconstitutes a NuRD complex with nucleosome remodeling activity.
CHD4 plays a pivotal role in chemoresistance and the maintenance of stemness in liver cancer stem cells and is therefore a good target for the eradication of hepatocellular carcinoma.
Acetyltransferase p300 (show EP300 Proteins) collaborates with chromodomain helicase DNA-binding protein 4 (CHD4) to facilitate DNA double-strand break repair
Specifically, methyl-CpG-binding domain protein 2 (MBD2 (show MBD2 Proteins)) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (show DPEP1 Proteins) domain and MBD2 (show DPEP2 Proteins) C-terminus.
these data build on our understanding of how CHD4-NuRD acts to regulate gene expression and participates in the DNA-damage response.
CHD4 depletion modulates expression of acute myeloid leukemia (show BCL11A Proteins) cell genes that regulate tumor formation in vivo and colony formation in vitro.
Also discovered a novel causative role for CHD4, a helicase involved in the histone deacetylase (show HDAC1 Proteins) complex that is associated with poor clinical outcome.
CHD4 modulates therapeutic response in BRCA2 (show BRCA2 Proteins) mutant cancer cells.
Endogenous Mta1 (show MTA1 Proteins)/2 forms a complex with chromodomain helicase (Chd)4, histone deacetylases (Hdac)1 (show HDAC1 Proteins)/2, RbAp46 (show RBBP7 Proteins)/48, and Mbd3 (show MBD3 Proteins) in rat cerebellum
CHD4 allows cells to undertake lineage commitment in vivo by modulating the frequency with which lineage-specification genes are expressed.
Chromatin immunoprecipitation assays showed that CHD4-containing NuRD complexes directly bound the promoters of these genes in endothelial cells
Chd4, interacting with Hdac1 (show HDAC1 Proteins)/2, cooperates with its related proteins Kap1 (show TRIM28 Proteins) and Cbx1 (show CBX1 Proteins) to bind at -207/-148 of the Sox9 (show SOX9 Proteins) promoter.
NuRD negatively regulates TIP5 expression, thereby inhibiting ribosomal DNA (rDNA) methylation and maintaining demethylation state of rDNA promoters.
The chromodomain helicase DNA-binding protein 4 (Chd4) is a critical interaction partner of Ezh2 (show EZH2 Proteins) required specifically for Polycomb (show CBX2 Proteins) group (PcG)-mediated suppression of the key astrogenic marker gene GFAP (show GFAP Proteins).
Gata3 (show GATA3 Proteins)/Chd4 forms functionally distinct complexes, which mediate both positive and negative gene regulation to facilitate Th2 cell differentiation.
In this study, we demonstrate that Mi2beta is required for gamma-globin gene silencing during adult definitive erythropoiesis
Concomitant deletion of Chd4 and Brg1 rescued vascular abnormalities seen in Brg1 mutant yolk sacs to the same extent as LiCl treatment.
CHD4 functions as a MAP required for MT stabilization and is involved in generating spindle bipolarity.
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
chromodomain helicase DNA binding protein 4
, chromodomain-helicase-DNA-binding protein 4
, ATP-dependent helicase CHD4
, Mi-2 autoantigen 218 kDa protein
, Mi-2 autoantigen
, Mi-2 beta