Chromodomain Helicase DNA Binding Protein 4 Proteins (CHD4)

The product of CHD4 belongs to the SNF2/RAD54 helicase family. Additionally we are shipping CHD4 Antibodies (80) and CHD4 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHD4 1108 Q14839
Rat CHD4 CHD4 117535  
Mouse CHD4 CHD4 107932 Q6PDQ2
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Top CHD4 Proteins at antibodies-online.com

Showing 4 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 11 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 13 to 16 Days
$486.00
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

CHD4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Chromodomain Helicase DNA Binding Protein 4 (CHD4) Interaction Partners

Human Chromodomain Helicase DNA Binding Protein 4 (CHD4) interaction partners

  1. The findings identify that CHD4 deficiency preferentially impairs cell survival via increasing the level of p21 (show CDKN1A Proteins).

  2. Mutation in CHD4 gene is associated with congenital heart defects.

  3. this work identifies CHD4 as an epigenetic coregulator of PAX3 (show PAX3 Proteins)-FOXO1 (show FOXO1 Proteins) activity, providing rational evidence for CHD4 as a potential therapeutic target in alveolar rhabdomyosarcoma.

  4. CHD4 recruits repressive chromatin proteins to sites of DNA damage repair, including DNA methyltransferases where it imposes de novo DNA methylation (show HELLS Proteins). At TSGs, CHD4 retention helps maintain DNA hypermethylation-associated transcriptional silencing.

  5. this study identifies the Chd4-Tbx3 (show TBX3 Proteins) axis in controlling ESC fate and a role of H2A.Z (show H2AFZ Proteins) in maintaining the stability of Chd4 proteins.

  6. report provides evidence for the role of CHD4 in human development and expands an increasingly recognized group of Mendelian disorders involving chromatin remodeling and modification

  7. complex lacking CHD4 that has HDAC (show HDAC3 Proteins) activity can exist as a stable species. The addition of recombinant CHD4 to this nucleosome deacetylase complex reconstitutes a NuRD complex with nucleosome remodeling activity.

  8. CHD4 plays a pivotal role in chemoresistance and the maintenance of stemness in liver cancer stem cells and is therefore a good target for the eradication of hepatocellular carcinoma.

  9. Acetyltransferase p300 (show EP300 Proteins) collaborates with chromodomain helicase DNA-binding protein 4 (CHD4) to facilitate DNA double-strand break repair

  10. Specifically, methyl-CpG-binding domain protein 2 (MBD2 (show MBD2 Proteins)) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (show DPEP1 Proteins) domain and MBD2 (show DPEP2 Proteins) C-terminus.

Mouse (Murine) Chromodomain Helicase DNA Binding Protein 4 (CHD4) interaction partners

  1. Chd4 mutant embryos died before birth and exhibited severe edema, blood-filled lymphatics, and liver hemorrhage. CHD4-deficient embryos developed normal lymphovenous (LV) valves, which regulate the return of lymph to the blood circulation; however, these valves lacked the fibrin-rich thrombi that prevent blood from entering the lymphatic system.

  2. This secreted effector, toxoplasma inhibitor of STAT1 (show STAT1 Proteins)-dependent transcription (TgIST), translocates to the host cell nucleus, where it recruits mouse Mi-2/NuRD to STAT1 (show STAT1 Proteins)-dependent promoters, resulting in altered chromatin and blocked transcription.

  3. this study shows that the chromatin remodeler Mi-2beta controls epidermal homeostasis by regulating the genes involved in keratinocyte and immune-cell activation to maintain an inactive state

  4. preservation of the identity of the two striated (show NSDHL Proteins) muscle types depends on epigenetic repression of the alternate lineage gene program by the chromatin remodeling complex Chd4/NuRD.

  5. complex lacking CHD4 that has HDAC (show HDAC3 Proteins) activity can exist as a stable species. The addition of recombinant CHD4 to this nucleosome deacetylase complex reconstitutes a NuRD complex with nucleosome remodeling activity.

  6. CHD4 depletion modulates expression of acute myeloid leukemia (show BCL11A Proteins) cell genes that regulate tumor formation in vivo and colony formation in vitro.

  7. CHD4 allows cells to undertake lineage commitment in vivo by modulating the frequency with which lineage-specification genes are expressed.

  8. Chromatin immunoprecipitation assays showed that CHD4-containing NuRD complexes directly bound the promoters of these genes in endothelial cells

  9. Chd4, interacting with Hdac1 (show HDAC1 Proteins)/2, cooperates with its related proteins Kap1 (show TRIM28 Proteins) and Cbx1 (show CBX1 Proteins) to bind at -207/-148 of the Sox9 (show SOX9 Proteins) promoter.

  10. NuRD negatively regulates TIP5 expression, thereby inhibiting ribosomal DNA (rDNA) methylation and maintaining demethylation state of rDNA promoters.

Xenopus laevis Chromodomain Helicase DNA Binding Protein 4 (CHD4) interaction partners

  1. CHD4 functions as a MAP required for MT stabilization and is involved in generating spindle bipolarity.

CHD4 Protein Profile

Protein Summary

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.

Gene names and symbols associated with CHD4

  • chromodomain helicase DNA binding protein 4 (CHD4)
  • chromodomain helicase DNA binding protein 4a (chd4a)
  • chromodomain helicase DNA binding protein 4b (chd4b)
  • chromodomain helicase DNA binding protein 4 (chd4)
  • chromodomain helicase DNA binding protein 4 (Chd4)
  • 9530019N15Rik protein
  • AA617397 protein
  • b230399n07 protein
  • BC005710 protein
  • CHD4 protein
  • D6Ertd380e protein
  • im:7143343 protein
  • MGC145363 protein
  • Mi-2 protein
  • Mi-2b protein
  • Mi-2beta protein
  • Mi2-BETA protein
  • mKIAA4075 protein
  • si:ch211-51m24.3 protein
  • si:ch211-57k11.10 protein
  • wu:fb44b12 protein
  • wu:fd12d03 protein

Protein level used designations for CHD4

chromodomain helicase DNA binding protein 4 , chromodomain-helicase-DNA-binding protein 4 , ATP-dependent helicase CHD4 , CHD-4 , Mi-2 autoantigen 218 kDa protein , Mi-2 autoantigen , Mi-2 beta

GENE ID SPECIES
418278 Gallus gallus
451788 Pan troglodytes
558344 Danio rerio
560622 Danio rerio
100059817 Equus caballus
100124711 Xenopus (Silurana) tropicalis
100515610 Sus scrofa
100539798 Meleagris gallopavo
100566510 Anolis carolinensis
1108 Homo sapiens
117535 Rattus norvegicus
107932 Mus musculus
380196 Xenopus laevis
477714 Canis lupus familiaris
506402 Bos taurus
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