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CHD8 encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. Additionally we are shipping CHD8 Kits (3) and and many more products for this protein.
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Human Polyclonal CHD8 Primary Antibody for ELISA, WB - ABIN566153
Rodenberg, Hoggatt, Chen, Touw, Jones, Herring: Regulation of serum response factor activity and smooth muscle cell apoptosis by chromodomain helicase DNA-binding protein 8. in American journal of physiology. Cell physiology 2010
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Study provides evidence that links the CHD8 chromatin remodeler to the cancer maintenance functions of BRD4 (show BRD4 Antibodies) and NSD3 (show WHSC1L1 Antibodies).
Taken together our data demonstrate that CHD8 is involved in late stages of progesterone receptor (show PGR Antibodies) enhancers activation.
Loss of CHD8 contributes to autism spectrum disorder by perturbing an ancient gene regulatory network during human brain development.
CHD8 insufficiency results in altered gene expression of coding genes and noncoding RNAs. The changes among protein-coding genes involved genes that are enriched in neuronal development and in previously identified autism candidate genes.
In the first detailed analysis in cancer, a marked loss of CHD8 expression and increased BORIS (show CTCFL Antibodies)/CTCF (show CTCF Antibodies) ratio indicate frequent disruption of CTCF (show CTCF Antibodies) and its effector genes in PCa (show FLVCR1 Antibodies).
Recurrent approximately 100 Kb microdeletion in the chromosomal region 14q11.2, involving CHD8 gene, is associated with autism and macrocephaly.
CHD8 precipitates a network of gene-expression changes involved in neurodevelopmental pathways in which many autism spectrum disorder-associated genes may converge on shared mechanisms of pathogenesis
indings suggest that CHD8 disruptions represent a specific pathway in the development of Autism spectrum disorder (ASD (show ARSD Antibodies)) and define a distinct ASD (show ARSD Antibodies) subtype. Common phenotypic features include increased head size; a facial phenotype marked by prominent forehead, wide-set eyes, and pointed chin; as well as increased rates of GI complaints and marked sleep dysfunction.
CHD8 is required for E2F (show E2F1 Antibodies)-dependent transcription activation of S-phase genes
Loss of CHD8 expression is associated with aggressiveness in gastric cancer.
The chromatin regulator CHD8 is a context-dependent mediator of cell survival in murine hematopoietic malignancies.
Chd8 promotes the association of beta-catenin (show CTNNB1 Antibodies) and histone H1 (show H1F0 Antibodies), with formation of the trimeric complex on chromatin being required for inhibition of beta-catenin (show CTNNB1 Antibodies)-dependent transactivation.
These data suggest that CHD8 plays a dual role in smooth muscle cells modulating SRF activity toward differentiation genes and promoting cell survival through interactions with both SRF and CTCF (show CTCF Antibodies) to regulate expression of Birc5 (show BIRC5 Antibodies) and CARD10 (show CARD10 Antibodies).
These observations reveal a mode of p53 (show TP53 Antibodies) regulation mediated by CHD8, which may set a threshold for induction of apoptosis during early embryogenesis by counteracting p53 (show TP53 Antibodies) function through recruitment of histone H1 (show H1F0 Antibodies).
This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
chromodomain helicase DNA binding protein 8
, chromodomain-helicase-DNA-binding protein 8
, ATP-dependent helicase CHD8
, chromodomain-helicase-DNA-binding protein 8-like
, axis duplication inhibitor
, helicase with SNF2 domain 1
, beta-catenin binding protein
, chromodomain helicase DNA binding protein family