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anti-Chromodomain Helicase DNA Binding Protein 8 (CHD8) Antibodies

CHD8 encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. Additionally we are shipping CHD8 Kits (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CHD8 57680 Q9HCK8
CHD8 67772 Q09XV5
Anti-Rat CHD8 CHD8 65027 Q9JIX5
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Top anti-CHD8 Antibodies at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.63 KDa) . 200 μL Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IF, IP, IHC (p), WB   100 μL Log in to see 8 to 10 Days
$595.83
Details
Human Mouse Un-conjugated IF, ELISA, WB   50 μg Log in to see 11 to 16 Days
$553.14
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$273.90
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$306.90
Details
Human Rabbit Un-conjugated IP, WB   20 μg Log in to see 8 to 10 Days
$815.83
Details
Human Rabbit Un-conjugated IP, WB   100 μg Log in to see 8 to 10 Days
$815.83
Details

CHD8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human ,
,
,
Mouse (Murine)


Top referenced anti-CHD8 Antibodies

  1. Human Polyclonal CHD8 Primary Antibody for ELISA, WB - ABIN566153 : Rodenberg, Hoggatt, Chen, Touw, Jones, Herring: Regulation of serum response factor activity and smooth muscle cell apoptosis by chromodomain helicase DNA-binding protein 8. in American journal of physiology. Cell physiology 2010 (PubMed)
    Show all 2 references for ABIN566153

More Antibodies against CHD8 Interaction Partners

Human Chromodomain Helicase DNA Binding Protein 8 (CHD8) interaction partners

  1. Study provides evidence that links the CHD8 chromatin remodeler to the cancer maintenance functions of BRD4 (show BRD4 Antibodies) and NSD3 (show WHSC1L1 Antibodies).

  2. Taken together our data demonstrate that CHD8 is involved in late stages of progesterone receptor (show PGR Antibodies) enhancers activation.

  3. Loss of CHD8 contributes to autism spectrum disorder by perturbing an ancient gene regulatory network during human brain development.

  4. CHD8 insufficiency results in altered gene expression of coding genes and noncoding RNAs. The changes among protein-coding genes involved genes that are enriched in neuronal development and in previously identified autism candidate genes.

  5. In the first detailed analysis in cancer, a marked loss of CHD8 expression and increased BORIS (show CTCFL Antibodies)/CTCF (show CTCF Antibodies) ratio indicate frequent disruption of CTCF (show CTCF Antibodies) and its effector genes in PCa (show FLVCR1 Antibodies).

  6. Recurrent approximately 100 Kb microdeletion in the chromosomal region 14q11.2, involving CHD8 gene, is associated with autism and macrocephaly.

  7. CHD8 precipitates a network of gene-expression changes involved in neurodevelopmental pathways in which many autism spectrum disorder-associated genes may converge on shared mechanisms of pathogenesis

  8. indings suggest that CHD8 disruptions represent a specific pathway in the development of Autism spectrum disorder (ASD (show ARSD Antibodies)) and define a distinct ASD (show ARSD Antibodies) subtype. Common phenotypic features include increased head size; a facial phenotype marked by prominent forehead, wide-set eyes, and pointed chin; as well as increased rates of GI complaints and marked sleep dysfunction.

  9. CHD8 is required for E2F (show E2F1 Antibodies)-dependent transcription activation of S-phase genes

  10. Loss of CHD8 expression is associated with aggressiveness in gastric cancer.

Mouse (Murine) Chromodomain Helicase DNA Binding Protein 8 (CHD8) interaction partners

  1. The chromatin regulator CHD8 is a context-dependent mediator of cell survival in murine hematopoietic malignancies.

  2. Chd8 promotes the association of beta-catenin (show CTNNB1 Antibodies) and histone H1 (show H1F0 Antibodies), with formation of the trimeric complex on chromatin being required for inhibition of beta-catenin (show CTNNB1 Antibodies)-dependent transactivation.

  3. These data suggest that CHD8 plays a dual role in smooth muscle cells modulating SRF activity toward differentiation genes and promoting cell survival through interactions with both SRF and CTCF (show CTCF Antibodies) to regulate expression of Birc5 (show BIRC5 Antibodies) and CARD10 (show CARD10 Antibodies).

  4. These observations reveal a mode of p53 (show TP53 Antibodies) regulation mediated by CHD8, which may set a threshold for induction of apoptosis during early embryogenesis by counteracting p53 (show TP53 Antibodies) function through recruitment of histone H1 (show H1F0 Antibodies).

Zebrafish Chromodomain Helicase DNA Binding Protein 8 (CHD8) interaction partners

  1. CHD8 precipitates a network of gene-expression changes involved in neurodevelopmental pathways in which many autism spectrum disorder-associated genes may converge on shared mechanisms of pathogenesis

CHD8 Antigen Profile

Protein Summary

This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CHD8

  • chromodomain helicase DNA binding protein 8 (CHD8) antibody
  • chromodomain helicase DNA binding protein 8 (Chd8) antibody
  • chromodomain helicase DNA binding protein 8 (chd8) antibody
  • 5830451P18Rik antibody
  • AU015341 antibody
  • AUTS18 antibody
  • CHD-8 antibody
  • Chd8 antibody
  • Duplin antibody
  • fi45h08 antibody
  • HELSNF1 antibody
  • mKIAA1564 antibody
  • si:ch211-10e2.6 antibody
  • wu:fi45h08 antibody

Protein level used designations for CHD8

chromodomain helicase DNA binding protein 8 , chromodomain-helicase-DNA-binding protein 8 , ATP-dependent helicase CHD8 , chromodomain-helicase-DNA-binding protein 8-like , axis duplication inhibitor , duplin , helicase with SNF2 domain 1 , CHD-8 , beta-catenin binding protein , chromodomain helicase DNA binding protein family

GENE ID SPECIES
475401 Canis lupus familiaris
507111 Bos taurus
739837 Pan troglodytes
100023377 Monodelphis domestica
100059337 Equus caballus
100192376 Xenopus (Silurana) tropicalis
100406255 Callithrix jacchus
100439513 Pongo abelii
100464946 Ailuropoda melanoleuca
100595705 Nomascus leucogenys
57680 Homo sapiens
67772 Mus musculus
65027 Rattus norvegicus
568214 Danio rerio
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