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CDY1 encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain.
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Cow (Bovine) Polyclonal CDY1 Primary Antibody for WB - ABIN2783449
Stouffs, Tournaye, Van der Elst, Haentjens, Liebaers, Lissens: Do we need to search for gr/gr deletions in infertile men in a clinical setting? in Human reproduction (Oxford, England) 2008
Findings showed that deletion of CDY1b (show CDY2A Antibodies) copy gene is a significant risk factor for male infertility independent of sperm concentration, whereas deletion of CDY1a gene seems to have no effect on fertility in the Tunisian population.
data indicate that CDY2 and HSFY (show HSFY2 Antibodies) are located within a segment of the Y chromosome that is important for sperm maturation, and are underexpressed in testicular tissue derived from men with maturation arrest
Assessing the expression of both CDY1 (show CDY2A Antibodies) and BOULE (show BOLL Antibodies) by qualitative RT-PCR is a sensitive and feasible test for predicting the presence of sperm cells in testicular tissue biopsies.
different functional roles for CDY isoforms during spermatogenesis
Partial AZFc deletions including CDY1-DAZ gene is associated with impaired spermatogenesis.
This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region\; this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined.
chromodomain protein, Y chromosome, 1
, testis-specific chromodomain protein Y 1
, testis-specific chromodomain protein on Y