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C10orf27 encodes a putative transcription factor that is highly expressed in thymic cortical stromal cells, and may be involved in T-cell development. Additionally we are shipping Chromosome 10 Open Reading Frame 27 Antibodies (36) and and many more products for this protein.
Functional analysis of the orthologous mouse protein.
C10orf27 is a candidate gene for multiple sclerosis susceptibility and pathogenesis
Spatial, through its transport by Kif17, is crucial for neuronal polarization.
Tbata modulates thymus function by regulating stromal cell proliferation via the Nedd8 (show NEDD8 ELISA Kits) pathway.
A new short thymus isoform, Spatial-beta, differs from other isoforms by an additional alternative exon of 69 bases. This new exon encodes an interesting proline-rich signature that could confer to the 34 kDa Spatial-beta protein a particular function.
Together, these findings imply a function of Spatial in spermatid differentiation as a new cargo of kinesin KIF17b, in a microtubule-dependent mechanism specific to the manchette and the principal piece of the sperm tail.
These findings suggest that Spatial may play a role in neuronal morphogenesis and synaptic plasticity through its interaction with the kinesin motor KIF17 in dendrites.
This gene encodes a putative transcription factor that is highly expressed in thymic cortical stromal cells, and may be involved in T-cell development. Its expression is developmentally regulated in the testis, where it is restricted to the haploid round spermatids during spermatogenesis, and thus this gene may also have a role in the control of male germ cell development. Alternative splicing of this gene results in two sets of transcript variants: the variants containing 5 additional exons at the 3' end encode long isoforms that are highly expressed in the testis, while the variants lacking the 3' end exons encode short isoforms that are highly expressed in the thymus. Most of the transcripts encoding the short isoforms have been shown to initiate translation from non-AUG (CUG) start sites.
, protein TBATA
, stromal protein associated with thymii and lymph node homolog
, thymus, brain and testes-associated protein
, stromal protein associated with thymii and lymph node
, stromal protein associated with thymii and lymph nodes
, thymus and testis specific nuclear protein