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Transcription regulator required for expression of CNS myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and central nervous system (CNS) myelination. Additionally we are shipping Chromosome 11open Reading Frame 9 Antibodies (16) and many more products for this protein.
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A Bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF.
mutant huntingtin (show HTT Proteins) binds abnormally to MYRF and affects its transcription activity
Here we identify Myrf as an oligodendrocyte-specific target of Sox10 (show SOX10 Proteins) and map a Sox10 (show SOX10 Proteins) responsive enhancer to an evolutionarily conserved element in intron 1 of the Myrf gene
Expression of MRF within the adult central nervous system (CNS) is critical to maintain oligodendrocyte identity and integrity of CNS myelin.
NPC1 (show NPC1 Proteins) protein was expressed in oligodendrocytes and the amount of myelin protein was generally decreased in all parts of the brain and spinal cord in NPC1 (show NPC1 Proteins)-mutant mice
Study identifies gene model 98, which we have named myelin gene regulatory factor (MRF), as a transcriptional regulator required for CNS myelination.
Transcription regulator required for expression of CNS myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and central nervous system (CNS) myelination. Probably acts as a transcription factor that directly binds DNA and activates expression of CNS myelin genes.
myelin gene regulatory factor