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anti-Chromosome 12 Open Reading Frame 5 (C12orf5) Antibodies

C12orf5 is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. Additionally we are shipping Chromosome 12 Open Reading Frame 5 Proteins (19) and Chromosome 12 Open Reading Frame 5 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
C12orf5 57103 Q9NQ88
C12orf5 319801 Q8BZA9
C12orf5    
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Top anti-Chromosome 12 Open Reading Frame 5 Antibodies at antibodies-online.com

Showing 10 out of 109 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of TIGAR in human brain tissue with this product at 2.5 μg/ml. Western blot analysis of TIGAR in EL4 cell lysate with this product at (A) 0.5, (B) 1 and (C) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of TIGAR in human brain tissue with TIGAAP30878PU-N at 2.5 μg/ml. Western blot analysis of TIGAR in MCF7 cell lysate with this product at (A) 0.5, (B) 1 and (C) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-C12orf5 / TIGAR antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN960902 concentration 10 ug/ml. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Mouse Rabbit Un-conjugated WB TIGAR Antibody (N-term)  western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the TIGAR antibody detected the TIGAR protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-C12orf5 / TIGAR antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN960901 concentration 10 ug/ml. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), WB Human Breast (formalin-fixed, paraffin-embedded) stained with C12orf5 antibody ABIN213914 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse intestine labeled with Rabbit Anti TIGAR Polyclonal Antibody, Unconjugated (ABIN671286) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse lung labeled with Rabbit Anti TIGAR Polyclonal Antibody, Unconjugated (ABIN671286) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details

C12orf5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Chromosome 12 Open Reading Frame 5 Antibodies

  1. Human Polyclonal C12orf5 Primary Antibody for EIA, IHC (p) - ABIN500907 : Corcoran, Huang, Sheikh: The regulation of energy generating metabolic pathways by p53. in Cancer biology & therapy 2007 (PubMed)
    Show all 3 references for ABIN500907

  2. Human Polyclonal C12orf5 Primary Antibody for EIA, IHC (p) - ABIN500909 : Guimaraes, Hainaut: TP53: a key gene in human cancer. in Biochimie 2002 (PubMed)
    Show all 3 references for ABIN500909

More Antibodies against Chromosome 12 Open Reading Frame 5 Interaction Partners

Human Chromosome 12 Open Reading Frame 5 (C12orf5) interaction partners

  1. TIGAR expression may be used as a bio-marker for detection of colorectal cancer and can be used as a target for developing therapeutics for the treatment of colorectal cancer.

  2. TIGAR knockdown reduced tumor growth rate.

  3. Geranylgeranoic acid induced upregulation of the TIGAR gene, which might inhibit the glycolysis in HuH-7 cells with p53 (show TP53 Antibodies) mutation.

  4. TIGAR over-expression could diminish the radiosensitivity of Hs 917.T cells, and the autophagy level induced by ionizing radiation (IR) was also decreased by TIGAR transfection.

  5. The Cdk5 (show CDK5 Antibodies)-AMT (show AMT Antibodies) signal pathway involved in regulation of DDR (show DDR1 Antibodies) by TIGAR.

  6. miR (show MLXIP Antibodies)-144 targeted TIGAR, inhibited proliferation, enhanced apoptosis, and increased autophagy in A549 and H460 cells

  7. Results revealed that TIGAR inhibits both apoptosis and autophagy.

  8. TIGAR is correlated with maximal standardized uptake value on FDG (show SMUG1 Antibodies)-PET and survival in non-small cell lung cancer.

  9. Data show targeting MUC1 (show MUC1 Antibodies)-C is synergistic with bortezomib (BTZ (show CASC3 Antibodies)) in suppressing p53 (show TP53 Antibodies)-inducible regulator of glycolysis and apoptosis (TIGAR)-mediated regulation of reactive oxygen species levels for combining GO-203 with BTZ (show CASC3 Antibodies) in BTZ (show CASC3 Antibodies) resistance.

  10. The kinetic properties and the structural similarity of the best substrates of TIGAR make it unlikely that TIGAR modulates cellular fructose 2,6-bisphosphate levels directly.

Mouse (Murine) Chromosome 12 Open Reading Frame 5 (C12orf5) interaction partners

  1. Results suggest that TIGAR expression changes during development and its expression level may be correlated with the vulnerability of neurons to ischemic injury.

  2. Although mouse TIGAR expression is clearly induced in the intestines of mice following DNA-damaging stress of ionizing radiation, that was not dependent on p53 (show TP53 Antibodies) or TAp73 (show TP73 Antibodies).

  3. TIGAR protein expression in brain is increased following ischemia reperfusion injury.

  4. Therefore, we conclude that TIGAR knockdown-induced radiosensitization of glioma cells may be dependent on the inhibition of TRX1 (show TXN Antibodies) nuclear translocation.

  5. TIGAR protects ischemic brain injury and preserves mitochodrial function.

  6. TIGAR has roles in efficient intestinal regeneration and tumorigenesis

  7. p53 (show TP53 Antibodies)/TIGAR-mediated inhibition of myocyte mitophagy is responsible for impairment of mitochondrial integrity and subsequent apoptosis.

  8. p53 (show TP53 Antibodies) and TIGAR inhibit glycolysis in hypoxic myocytes and that inhibition of glycolysis is closely involved in apoptosis, suggesting that p53 (show TP53 Antibodies) and TIGAR are significant mediators of cellular energy homeostasis and cell death under ischemic stress.

Chromosome 12 Open Reading Frame 5 (C12orf5) Antigen Profile

Protein Summary

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.

Gene names and symbols associated with C12orf5

  • chromosome 1 open reading frame, human C12orf5 (C1H12ORF5) antibody
  • chromosome 12 open reading frame 5 (c12orf5) antibody
  • chromosome 12 open reading frame 5 (LOC100226990) antibody
  • chromosome 12 open reading frame 5 (C12orf5) antibody
  • chromosome 5 open reading frame, human C12orf5 (C5H12orf5) antibody
  • RIKEN cDNA 9630033F20 gene (9630033F20Rik) antibody
  • AA793651 antibody
  • AI595337 antibody
  • C12orf5 antibody
  • C79710 antibody
  • C85509 antibody
  • FR2BP antibody
  • Tigar antibody

Protein level used designations for C12orf5

TP53-induced glycolysis and apoptosis regulator , fructose-2,6-bisphosphatase TIGAR , probable fructose-2,6-bisphosphatase TIGAR , chromosome 12 open reading frame 5 , fructose-2,6-bisphosphate 2-phosphatase , transactivated by NS3TP2 protein

GENE ID SPECIES
419040 Gallus gallus
100145723 Xenopus (Silurana) tropicalis
100226990 Taeniopygia guttata
57103 Homo sapiens
734566 Xenopus laevis
615392 Bos taurus
319801 Mus musculus
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