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C12orf5 is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. Additionally we are shipping Chromosome 12 Open Reading Frame 5 Antibodies (86) and Chromosome 12 Open Reading Frame 5 Proteins (19) and many more products for this protein.
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Geranylgeranoic acid induced upregulation of the TIGAR gene, which might inhibit the glycolysis in HuH-7 cells with p53 (show TP53 ELISA Kits) mutation.
TIGAR over-expression could diminish the radiosensitivity of Hs 917.T cells, and the autophagy level induced by ionizing radiation (IR) was also decreased by TIGAR transfection.
The Cdk5 (show CDK5 ELISA Kits)-AMT (show AMT ELISA Kits) signal pathway involved in regulation of DDR (show DDR1 ELISA Kits) by TIGAR.
miR (show MLXIP ELISA Kits)-144 targeted TIGAR, inhibited proliferation, enhanced apoptosis, and increased autophagy in A549 and H460 cells
Results revealed that TIGAR inhibits both apoptosis and autophagy.
TIGAR is correlated with maximal standardized uptake value on FDG (show SMUG1 ELISA Kits)-PET and survival in non-small cell lung cancer.
Data show targeting MUC1 (show MUC1 ELISA Kits)-C is synergistic with bortezomib (BTZ (show CASC3 ELISA Kits)) in suppressing p53 (show TP53 ELISA Kits)-inducible regulator of glycolysis and apoptosis (TIGAR)-mediated regulation of reactive oxygen species levels for combining GO-203 with BTZ (show CASC3 ELISA Kits) in BTZ (show CASC3 ELISA Kits) resistance.
The kinetic properties and the structural similarity of the best substrates of TIGAR make it unlikely that TIGAR modulates cellular fructose 2,6-bisphosphate levels directly.
CREB (show CREB1 ELISA Kits) regulates TIGAR expression via a CRE-binding site at the TIGAR promoter.
oroxylin A could increase protein and mRNA expression of TP53-induced glycolysis and apoptosis regulator (TIGAR) and synthesis of cytochrome c oxidase 2 (show COX2 ELISA Kits) (SCO2), which are the key metabolic modulators regulated by p53 (show TP53 ELISA Kits).
Results suggest that TIGAR expression changes during development and its expression level may be correlated with the vulnerability of neurons to ischemic injury.
Although mouse TIGAR expression is clearly induced in the intestines of mice following DNA-damaging stress of ionizing radiation, that was not dependent on p53 (show TP53 ELISA Kits) or TAp73 (show TP73 ELISA Kits).
TIGAR protein expression in brain is increased following ischemia reperfusion injury.
Therefore, we conclude that TIGAR knockdown-induced radiosensitization of glioma cells may be dependent on the inhibition of TRX1 (show TXN ELISA Kits) nuclear translocation.
TIGAR protects ischemic brain injury and preserves mitochodrial function.
TIGAR has roles in efficient intestinal regeneration and tumorigenesis
p53 (show TP53 ELISA Kits)/TIGAR-mediated inhibition of myocyte mitophagy is responsible for impairment of mitochondrial integrity and subsequent apoptosis.
p53 (show TP53 ELISA Kits) and TIGAR inhibit glycolysis in hypoxic myocytes and that inhibition of glycolysis is closely involved in apoptosis, suggesting that p53 (show TP53 ELISA Kits) and TIGAR are significant mediators of cellular energy homeostasis and cell death under ischemic stress.
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.
TP53-induced glycolysis and apoptosis regulator
, fructose-2,6-bisphosphatase TIGAR
, probable fructose-2,6-bisphosphatase TIGAR
, chromosome 12 open reading frame 5
, fructose-2,6-bisphosphate 2-phosphatase
, transactivated by NS3TP2 protein