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Chromosome 12 Open Reading Frame 52 (C12orf52) ELISA Kits

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Additionally we are shipping Chromosome 12 Open Reading Frame 52 Antibodies (22) and Chromosome 12 Open Reading Frame 52 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human C12orf52 C12orf52 84934 Q96K30
Anti-Mouse C12orf52 C12orf52 100764 Q9D1H0
Anti-Rat C12orf52 C12orf52 288683 Q2KJ10
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More ELISA Kits for Chromosome 12 Open Reading Frame 52 Interaction Partners

Xenopus laevis Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52) as a novel rbpj/CBF-1 (show RBPJ ELISA Kits)-interacting protein.

Human Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. RITA (show ZNF331 ELISA Kits) overexpression increased expression of p53 (show TP53 ELISA Kits) and Fbxw7 (show FBXW7 ELISA Kits) and downregulated expression of cyclin D1 (show CCND1 ELISA Kits), cyclin E (show CCNE1 ELISA Kits), CDK2 (show CDK2 ELISA Kits), Hes-1 and NF-kappaB (show NFKB1 ELISA Kits) p65 (show GORASP1 ELISA Kits). These changes led to growth inhibition and induced G0/G1 cell cycle arrest and apoptosis in SMMC7721 and HepG2 cells.

  2. human RITA (show ZNF331 ELISA Kits), binding to Drosophila Su(H (show RBPJ ELISA Kits)) and tubulin (show TUBB ELISA Kits), cannot influence the Notch (show NOTCH1 ELISA Kits) signalling pathway in the fly

  3. RITA (show ZNF331 ELISA Kits) might suppress tumor growth and induce apoptosis in hepatocellular carcinoma.

Chromosome 12 Open Reading Frame 52 (C12orf52) Antigen Profile

Antigen Summary

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity).

Gene names and symbols associated with C12orf52

  • chromosome 12 open reading frame 52 (C12orf52) antibody
  • chromosome 12 open reading frame 52 (c12orf52) antibody
  • chromosome 17 open reading frame, human C12orf52 (C17H12orf52) antibody
  • RIKEN cDNA 1110008J03 gene (1110008J03Rik) antibody
  • similar to RIKEN cDNA 1110008J03 (RGD1306772) antibody
  • AI853657 antibody
  • C12orf52 antibody
  • C86297 antibody
  • Rita antibody

Protein level used designations for C12orf52

chromosome 12 open reading frame 52 , RBP-J interacting and tubulin associated , RBPJ-interacting and tubulin-associated protein

GENE ID SPECIES
712837 Macaca mulatta
100381047 Xenopus laevis
84934 Homo sapiens
533158 Bos taurus
100764 Mus musculus
288683 Rattus norvegicus
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