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C12orf53 encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Additionally we are shipping Chromosome 12 Open Reading Frame 53 Proteins (5) and many more products for this protein.
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Cow (Bovine) Polyclonal C12orf53 Primary Antibody for WB - ABIN2785281
Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ... in Genome research 2003
Functionally, Leda-1/Pianp increased the transepithelial electrical resistance generated by a polarized cell sheet. While Claudin 1 (show CLDN7 Antibodies) and 4 expression and activities of small GTPases were not affected, gamma-Secretase-mediated cleavage of E-Cadherin (show CDH1 Antibodies) was attenuated by Leda-1/Pianp.
Furin (show FURIN Antibodies)-like proprotein convertase-dependent processing precedes the plasma membrane localization of LEDA-1/PIANP that is required for functional receptor-ligand interactions in vitro and in vivo.
These results suggest that PANP is involved in immune regulation as a ligand of the PILRalpha.
This gene encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Alternate splicing results in multiple transcript variants encoding different proteins.
PILR alpha-associated neural protein
, PILR-associating neural protein
, liver endothelial differentiation-associated protein-1
, paired immunoglobin-like type 2 receptor-associating neural protein
, chromosome 12 open reading frame 53