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Chromosome 12 Open Reading Frame 65 Proteins (C12orf65)

May act as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion (By similarity).. Additionally we are shipping C12orf65 Antibodies (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
C12orf65 91574 Q9H3J6
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Top C12orf65 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

C12orf65 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Chromosome 12 Open Reading Frame 65 (C12orf65) Interaction Partners

Human Chromosome 12 Open Reading Frame 65 (C12orf65) interaction partners

  1. We demonstrate that the identical nonsense mutation in C12orf65 can result in different clinical features

  2. our study delineates the broad spectrum of C12orf65 defects and establishes a distinct genotype-phenotype correlation. The obligatory clinical triad is optic atrophy, peripheral neuropathy, and spastic paraparesis.

  3. The C12orf65 gene encodes a mitochondrial matrix protein that is critical for the release of newly synthesized proteins from mitochondrial ribosomes.

  4. Truncating mutations in C12ORF65 lead to a variable phenotype with intellectual disability, spastic paraplegia, and ophthalmoplegia in 2 patients.

  5. This work describes a mutation in the C12orf65 gene that causes recessive form of CMT6 and confirms the role of mitochondrial dysfunction in this complex axonal neuropathy.

  6. A homozygous mutation of C12orf65 causes spastic paraplegia with optic atrophy and neuropathy.

  7. Knockdown of C12orf65 resulted in increased reactive oxidative species production and apoptosis, leading to inhibition of cell proliferation.

  8. C12orf65 might play a role in recycling abortive peptidyl-tRNA species, released from the ribosome during the elongation phase of translation.

C12orf65 Protein Profile

Protein Summary

May act as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion (By similarity).

Gene names and symbols associated with C12orf65

  • chromosome 12 open reading frame 65 (C12orf65)
  • COXPD7 protein
  • SPG55 protein

Protein level used designations for C12orf65

probable peptide chain release factor C12orf65, mitochondrial

GENE ID SPECIES
91574 Homo sapiens
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