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Chromosome 14 Open Reading Frame 169 (C14orf169) ELISA Kits

Histone demethylase that specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Additionally we are shipping C14orf169 + NO66 Antibodies (27) and C14orf169 + NO66 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human C14orf169 C14orf169 79697 Q9H6W3
Anti-Mouse C14orf169 C14orf169 71952 Q9JJF3
Anti-Rat C14orf169 C14orf169 314300 D3ZU57
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More ELISA Kits for C14orf169 + NO66 Interaction Partners

Cow (Bovine) Chromosome 14 Open Reading Frame 169 (C14orf169) interaction partners

  1. PHF19 associates with the H3K36me3 demethylase (show MBD2 ELISA Kits) NO66, and it is required to recruit the PRC2 complex and NO66 to stem cell genes during differentiation

Human Chromosome 14 Open Reading Frame 169 (C14orf169) interaction partners

  1. Results show that high expression levels of SMYD2 (show SMYD2 ELISA Kits), SETD3 (show SETD3 ELISA Kits), and NO66 in renal cell tumors. Their low expression levels were significantly associated with shorter disease-specific and disease-free survival.

  2. confirmed the hydroxylase activity of NO66 and showed that oligomerization is required for NO66 to efficiently catalyze the hydroxylation of Rpl8 (show RPL8 ELISA Kits)

  3. hinge domain-dependent oligomerization of NO66 is essential for inhibition of Osx (show MID1 ELISA Kits)-dependent gene activation.

  4. NO66 crystallized in space group P3(1) or P3(2), with unit-cell parameters a = 89.35, b = 89.35, c = 304.86 A, alpha = beta = 90, gamma = 120 degrees , and the crystal is likely to contain four molecules in the asymmetric unit

  5. interactions between NO66 and Osx (show MID1 ELISA Kits) regulate Osx (show MID1 ELISA Kits)-target genes in osteoblasts by modulating histone methylation states

  6. NO66 has functions in ribosome biogenesis and in the replication or remodeling of certain heterochromatic regions

Mouse (Murine) Chromosome 14 Open Reading Frame 169 (C14orf169) interaction partners

  1. NO66 regulates bone formation, at least in part, via regulating the number of bone-forming cells and expression of multiple genes that are critical for these processes

  2. Data indicate that mesenchymal overexpression of nucleolar protein 66 (NO66) inhibits skeletal cell proliferation.

  3. propose that Osx (show SP7 ELISA Kits) is a molecular switch for the formation of an active chromatin state during osteoblast differentiation, whereas NO66 helps gene repression through histone demethylation and/or formation of a repressor complex

C14orf169 + NO66 (C14orf169) Antigen Profile

Antigen Summary

Histone demethylase that specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with sp7/osx by demethylating H3K4me and H3K36me, thereby inhibiting sp7/osx-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region (By similarity).

Gene names and symbols associated with C14orf169

  • chromosome 14 open reading frame 169 (LOC453015) antibody
  • chromosome 14 open reading frame 169 (Bm1_08415) antibody
  • chromosome 14 open reading frame 169 (LOC100219109) antibody
  • chromosome 10 open reading frame, human C14orf169 (NO66) antibody
  • chromosome 14 open reading frame 169 (C14orf169) antibody
  • chromosome 5 open reading frame, human C14orf169 (C5H14ORF169) antibody
  • RIKEN cDNA 2410016O06 gene (2410016O06Rik) antibody
  • similar to RIKEN cDNA 2410016O06 (RGD1307704) antibody
  • zgc:162967 (zgc:162967) antibody
  • C10H14orf169 antibody
  • C14orf169 antibody
  • im:7141580 antibody
  • LOC453015 antibody
  • MAPJD antibody
  • no66 antibody
  • ROX antibody

Protein level used designations for C14orf169

chromosome 14 open reading frame 169 , bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 , histone lysine demethylase NO66 , lysine-specific demethylase NO66 , myc-associated protein with JmjC domain , nucleolar protein 66 , 60S ribosomal protein L8 histidine hydroxylase , MYC-associated protein with JmjC domain , hsNO66 , ribosomal oxygenase NO66 , myc associated protein with JmjC domain , chromosome 14 open reading frame 169-like

GENE ID SPECIES
453015 Pan troglodytes
6096611 Brugia malayi
100219109 Taeniopygia guttata
511031 Bos taurus
79697 Homo sapiens
423249 Gallus gallus
71952 Mus musculus
314300 Rattus norvegicus
560815 Danio rerio
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