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Chromosome 19 Open Reading Frame 40 (C19ORF40) ELISA Kits

FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Chromosome 19 Open Reading Frame 40 Antibodies (5) and Chromosome 19 Open Reading Frame 40 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human C19ORF40 C19ORF40 91442 Q9BTP7
Anti-Mouse C19ORF40 C19ORF40 101831 Q8BHL6
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More ELISA Kits for Chromosome 19 Open Reading Frame 40 Interaction Partners

Human Chromosome 19 Open Reading Frame 40 (C19ORF40) interaction partners

  1. These results demonstrate dual roles of FAAP24 in DNA damage response against crosslinking lesions, one through the formation of FANCM (show FANCM ELISA Kits)/FAAP24 heterodimer and the other via its ssDNA-binding activity required in optimized checkpoint activation.

  2. Crystal structure of the FANCM (show FANCM ELISA Kits)-FAAP24 complex.

  3. Results show that the first HhH (show SLC25A15 ELISA Kits) motif of FAAP24 is a potential binding site for DNA, which plays a critical role in targeting FANCM (show FANCM ELISA Kits)-FAAP24 to chromatin.

  4. FANCM (show FANCM ELISA Kits) and FAAP24 play multiple, while not fully epistatic, roles in maintaining genomic integrity.

  5. FANCM/FAAP24 plays a role in ICL-induced checkpoint activation through regulating RPA recruiment at ICL-stalled replication forks.

  6. FAAP24 targets FANCM (show FANCM ELISA Kits) to structures that mimic intermediates formed during the replication/repair of damaged DNA.

  7. FANCM (show FANCM ELISA Kits) is an anchor required for recruitment of the FA core complex to chromatin, and the FANCM (show FANCM ELISA Kits)/FAAP24 interaction is essential for this chromatin-loading activity

  8. FAAP24 is dispensable for DNA binding and branch migration activity of FANCM (show FANCM ELISA Kits).

  9. DNA damage recognition and remodeling activities of FANCM (show FANCM ELISA Kits) and FAAP24 cooperate to promote efficient activation of DNA damage checkpoints in Fanconi anemia (show PALB2 ELISA Kits).

Chromosome 19 Open Reading Frame 40 (C19ORF40) Antigen Profile

Antigen Summary

FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007

Gene names and symbols associated with C19ORF40

  • chromosome 18 open reading frame, human C19orf40 (C18H19orf40) antibody
  • chromosome 19 open reading frame 40 (C19orf40) antibody
  • RIKEN cDNA C230052I12 gene (C230052I12Rik) antibody
  • AW124591 antibody
  • AW538696 antibody
  • Faap24 antibody

Protein level used designations for C19ORF40

Fanconi anemia-associated protein of 24 kDa , Fanconi anemia-associated protein, 24 kDa

GENE ID SPECIES
510793 Bos taurus
91442 Homo sapiens
101831 Mus musculus
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