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C4orf7 encodes a small secreted protein that is expressed in follicular dendritic cells. Additionally we are shipping Chromosome 4 Open Reading Frame 7 Proteins (3) and and many more products for this protein.
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Our results demonstrate a novel biological activity of FDC-SP in controlling B-cell IgA production and identify FDC-SP-deficient mice as a novel mouse model of IgAN.
FDC-SP may be involved in IgA production in the tonsils of Immunoglobulin A nephropathy patients.
FDC-SP overexpression inhibits osteogenic differentiation of hPDLCs. study contributes to a better understanding of biological functions governing FDC-SP-induced hPDLC differentiation.
Our findings demonstrate that transfection with FDC-SP has negligible adverse effect on proliferation of hPDLCs and imply the biological function of FDC-SP as a fibroblastic phenotype stabilizer
The role of C4orf7 in ovarian cancer cell morphology, motility and invasion was demonstrated.
FDC-SP has a very restricted tissue distribution, expressed by activated FDCs from tonsils and TNF-alpha (show TNF Antibodies)-activated FDC (show LAG3 Antibodies)-like cell lines, but not by B cell lines, primary germinal center B cells, or anti-CD40 (show CD40 Antibodies) plus IL-4 (show IL4 Antibodies)-activated B cells.
Since only normal tissue was examined, these findings suggest that FDC-SP plays an important but previously unsuspected role within oral connective tissue.
These results provide the first evidence for immunomodulatory activities of FDC-SP and implicate this molecule as a regulator of B cell responses.
This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion.
follicular dendritic cell secreted peptide
, chromosome 4 open reading frame 7
, FDC secreted protein