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Exhibits broad antiviral activity, most probably causing an early viral translation block.. Additionally we are shipping Chromosome 6 Open Reading Frame 150 Antibodies (36) and many more products for this protein.
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cGAS and STING are intracellular sensors that activate the interferon (show IFNA Proteins) pathway in response to virus infection. [review]
cGAS silencing inhibited production of proinflammatory cytokines and matrix metalloproteinases (MMPs) as well as AKT (show AKT1 Proteins) and ERK (show EPHB2 Proteins) phosphorylation in TNFalpha (show TNF Proteins)-stimulated fibroblast-like synoviocytes
A STING-dependent, cGAS-independent pathway important for full interferon (show IFNA Proteins) production and antiviral control of enveloped RNA viruses.
By directly binding to cGAS, LANA, and particularly, a cytoplasmic isoform, inhibit the cGAS-STING-dependent phosphorylation of TBK1 (show TBK1 Proteins) and IRF3 (show IRF3 Proteins) and thereby antagonize the cGAS-mediated restriction of KSHV lytic replication.
TRIM21 (show TRIM21 Proteins)-induced exposure of the viral genome promotes sensing of DNA and RNA viruses by cGAS and RIG-I (show DDX58 Proteins)
cGAS is an innate sensor of Mycobacterium tuberculosis.Mycobacterium tuberculosis differentially activates cGAS- and inflammasome-dependent intracellular immune responses through ESX-1 (show ESX1 Proteins).
Study found that PQBP1 (show PQBP1 Proteins) directly binds to reverse-transcribed HIV-1 DNA and interacts with cGAS to initiate an IRF3 (show IRF3 Proteins)-dependent innate response.
Studies in THP-1 knockout cells revealed that the recognition of RNA:DNA hybrids is completely attributable to the cGAS-STING pathway.
IFI16 (show IFI16 Proteins) and cGAS cooperate in a novel way to sense nuclear herpesviral DNA and initiate innate signaling
The cGAS/STING/TBK1 (show TBK1 Proteins)/IRF3 (show IRF3 Proteins) cascade was not a direct target of viral antihost strategies, and authors found no evidence that adenovirus stimulation of the cGAS/STING DNA response had an impact on viral replication efficiency.
Exhibits broad antiviral activity, most probably causing an early viral translation block.
chromosome 6 open reading frame 150
, cGAMP synthase
, cyclic GMP-AMP synthase
, mab-21 domain-containing protein 1
, protein MB21D1