anti-Chromosome 7 Open Reading Frame 27 (C7orf27) Antibodies

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. Additionally we are shipping BAAT1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
C7orf27 221927 Q6PJG6
C7orf27 231841 Q8C3R1
C7orf27    
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Top anti-BAAT1 Antibodies at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-BRAT1 Antibody Titration: 1.0 ug/ml Positive Control: HepG2 Whole Cell 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IP, IHC, WB Immunohistochemistry-Paraffin: BAAT1 Antibody [ABIN151679] - FFPE section of human metastatic lymph node. ABIN151679 used at a dilution of 1:250. 0.1 mL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Paraformaldehyde-fixed, paraffin embedded human lung cancer, Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes, Blocking buffer (normal goat serum) at 37°C for 30min, Antibody incubation with C7orf27 Polyclonal Antibody, Unconjugated  at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining. 100 μL Log in to see 14 to 21 Days
$295.90
Details
Human Mouse Un-conjugated WB Western Blot analysis of C7orf27 expression in transfected 293T cell line by C7orf27 MaxPab polyclonal antibody.<br><br>Lane 1: C7orf27 transfected lysate(90.31 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μL Log in to see 11 to 12 Days
$430.00
Details
Human Rabbit Un-conjugated ICC, IF Immunocytochemistry/Immunofluorescence: BAAT1 Antibody  - Staining of human cell line U-2 OS shows localization to nucleoplasm. 100 μL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry: BAAT1 Antibody [NBP1-88366] - Staining of human kidney shows strong membranous positivity in glomerular cells. Western Blot: BAAT1 Antibody [NBP1-88366] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10 Lane 2: Negative control (vector only transfected HEK293T lysate) Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY407296) 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IP, WB   20 μg Log in to see 7 to 9 Days
$815.83
Details
Human Rabbit Un-conjugated IF, IP, IHC (p), WB   100 μL Log in to see 7 to 9 Days
$595.83
Details

C7orf27 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , ,
,

Mouse (Murine)


Rat (Rattus)


More Antibodies against BAAT1 Interaction Partners

Human Chromosome 7 Open Reading Frame 27 (C7orf27) interaction partners

  1. Biallelic sequence variants in BRAT1 have been reported to cause a variety of ocular and systemic manifestations, but to our knowledge, this is the first report of inner retinal dysfunction manifest as selective loss of full-field ERG (show ERG Antibodies) scotopic and photopic b-wave amplitudes.

  2. compared with RMFSL, BRAT1 mutations can result in both moderately severe presentations evident by later-onset epilepsy and survival past infancy, as well as milder presentations that include intellectual disability, ataxia/dyspraxia, and cerebellar atrophy.

  3. our data expand the clinical symptoms and demonstrate variability in the natural clinical course of BRAT1-associated phenotypes. Patients with early onset seizures, postnatal microcephaly, feeding problems, and muscular hypertonia or contractures should hence be screened for BRAT1 mutations.

  4. we report two affected siblings with compound heterozygous truncating mutations in BRAT1 and intra-familial phenotypic heterogeneity, with a less severe disease course in the female sibling. This phenotypic variability should be taken into account when treating patients with BRAT1-associated neurodegenerative disease.

  5. We conclude that BRAT1 should be added to the growing list of genes related to early-onset severe encephalopathy with epilepsy.

  6. Our results further support that mutations of BRAT1 could lead to epileptic encephalopathy.

  7. Ndfip1 (show NDFIP1 Antibodies) is required during stress for ubiquitinating and trafficking BRAT1 into the nucleus.

  8. Findings suggest novel roles of BRAT1 in cell proliferation and mitochondrial functions.

  9. Data on crystal structure of BRCA1 binding with phosphopeptides suggest that C-terminal domain of BRCA1 interacts with BAAT1 and ATRIP (show ATRIP Antibodies) with preferences for specific side chains; in BAAT1, phospho-Ser269 and Phe272 are the main interacting residues.

  10. Study identified sequence variants in the known disease-causing genes SLC6A3 (show SLC6A3 Antibodies) and FLVCR1 (show FLVCR1 Antibodies), and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6 (show TUBGCP6 Antibodies), BRAT1, SNIP1 (show SNIP1 Antibodies), CRADD (show CRADD Antibodies), and HARS (show HARS Antibodies).

Mouse (Murine) Chromosome 7 Open Reading Frame 27 (C7orf27) interaction partners

  1. Ndfip1 (show NDFIP1 Antibodies) is required during stress for ubiquitinating and trafficking BRAT1 into the nucleus.

BAAT1 (C7orf27) Antigen Profile

Protein Summary

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.

Gene names and symbols associated with C7orf27

  • BRCA1 associated ATM activator 1 (BRAT1) antibody
  • BRCA1-associated ATM activator 1 (Brat1) antibody
  • BRCA1-associated ATM activator 1 (brat1) antibody
  • AA881470 antibody
  • baat1 antibody
  • C7orf27 antibody
  • RMFSL antibody
  • zgc:136845 antibody

Protein level used designations for C7orf27

BRCA1-associated protein required for ATM activation protein 1 , HEAT repeat-containing protein C7orf27 , HEAT repeat-containing protein C7orf27 homolog

GENE ID SPECIES
769893 Gallus gallus
221927 Homo sapiens
231841 Mus musculus
678547 Danio rerio
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