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Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier (By similarity). Additionally we are shipping Cingulin Antibodies (15) and and many more products for this protein.
Cingulin modulates barrier function in endothelium.
MgcRacGAP (show RACGAP1 ELISA Kits) colocalizes with CGN and CGNL1 (show CGNL1 ELISA Kits) at TJs and forms a complex and interacts directly in vitro with CGN and CGNL1 (show CGNL1 ELISA Kits).
Co-imunoprecipitation and confocal microscopy experiments also revealed the tight junction protein cingulin as a new interacting partner of Ubn-1
Results indicate that cells underwent EMT (show ITK ELISA Kits) exhibited overactive TGFbeta (show TGFB1 ELISA Kits) signaling and loss of expression of the CDH1 (show CDH1 ELISA Kits), CGN, CLDN4 (show CLDN4 ELISA Kits), and KLK10 (show KLK10 ELISA Kits) genes as a result of hypermethylation of their corresponding promoter regions.
Cingulin (KIAA1319 protein) is localized in the cytoplasmic domain of vertebrate epithelial tight junctions, and it interacts with other tight junction proteins such as ZO-1 (show TJP1 ELISA Kits), and with the actomyosin cytoskeleton.
the regulated cingulin-microtubule association has a specific role in tight junction-related epithelial morphogenesis that is sensitive to metabolic homeostasis-related AMPK (show PRKAA1 ELISA Kits) activity.
cingulin is dispensable for the structure and barrier function of tight junctions, and is embedded in signaling networks that control the expression of claudin-2 (show CLDN2 ELISA Kits).
Data show by immunofluorescence labeling that the cytoskeletal-associated protein cingulin, commonly found at tight junctions, is also localized at neuronal gap junctions throughout the central nervous system.
cingulin does not have a critical role in tight-junction formation, but gene expression and tight junction protein (show OCLN ELISA Kits) levels are altered by the cingulin mutation
Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier (By similarity).
, hypothetical protein LOC100145755