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The protein encoded by CS is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. Additionally we are shipping Citrate Synthase Kits (44) and Citrate Synthase Proteins (15) and many more products for this protein.
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Data suggest that downregulation of citrate synthase (CS) expression in 293T cells leads to low level of ATP production, excessive superoxide formation and cell apoptosis, which implies a possible mechanism for hearing loss in A/J mice.
Hence, we conclude that SIRT3 (show SIRT3 Antibodies) exhibits neuroprotection via deacetylating and increasing mitochondrial enzyme activities.
The citrate synthase knockdown cells exhibited severe defects in respiratory activity and marked decreases in ATP production, but great increases in glycolytic metabolism.
Citrate synthase (CS) is a direct RORalpha target gene and one mechanism by which RORalpha regulates lipid metabolism is via regulation of CS expression.
It is likely that enhanced citrate synthase activity contributes to the conversion of glucose to lipids in pancreatic cancer providing substrate for membrane lipids synthesis.
These results provide an important basis for the study of mitochondrial dysfunction due to aberrant CSa trafficking.
The CS activity decreased in the infarcted tissue of wild-type (WT) mice at day 1 post-MI (p<0.05), but this was not observed in the MMP-9 (show MMP9 Antibodies) null mice, suggesting that MMP-9 (show MMP9 Antibodies) deletion helps to maintain the mitochondrial activity post-MI
Multiple lines of evidence implicate this missense mutation (H55N) as the underlying cause of ahl4-related hearing loss, likely through its effects on mitochondrial adenosine trisphosphate (ATP) and free radical production in cochlear hair cells.
CS and SERCA (show ATP2A3 Antibodies) activities were significantly higher in the pubococcygeus (Pc) compared with the ischiocavernosus/bulbospongiosus (Ic/Bs) pelvic floor muscles, whereas the ChAT activity of the Ic/Bs was higher than that of the Pc muscle.
The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found.
citrate synthase, mitochondrial
, Citrate synthase, mitochondrial