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CIT encodes a serine/threonine-protein kinase that functions in cell division. Additionally we are shipping CIT Proteins (2) and CIT Kits (1) and many more products for this protein.
Showing 10 out of 27 products:
Human Monoclonal CIT Primary Antibody for IF, WB - ABIN968502
Di Cunto, Calautti, Hsiao, Ong, Topley, Turco, Dotto: Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. in The Journal of biological chemistry 1998
Show all 4 references for ABIN968502
Data propose that the CC-domain-mediated translocation and actions of Citron-K ensure proper stabilization of the midbody structure during the transition from constriction to abscission.
p27 (show CDKN1B Antibodies) has a role in cytokinesis via the regulation of citron-K activity
CITRON has a role in proliferation of hepatocellular carcinoma cells
Data report that Discs large (show DLG4 Antibodies) 5 (Dlg5 (show DLG5 Antibodies)), a member of the MAGUK family, is an interactor of CitK required for CitK polarization.
Citron-K has a distinct cell cycle-dependent expression pattern and cellular localization as a downstream target of Rho-GTPase (show RACGAP1 Antibodies) and functions in the control of G(2)/M transition in the hepatocyte cell cycle
Quantitative analysis of citron kinase in cerebral cortex of knockout mice demonstrates that this molecule is involved in differentially regulating the morphology of the dendritic compartment in corticocollicular projecting pyramidal neurons.
These results suggest that the TTC3 (show TTC3 Antibodies)-RhoA (show RHOA Antibodies)-CIT-K pathway could be a crucial determinant of in vivo neuronal development, whose hyperactivity may result in detrimental effects on the normal differentiation program.
Lack of citron kinase gene in newborn mice profoundly alters barrelfield cortex cell morphology and number.
The TPC1 was shown to interact with citron kinase, with TPC1 overexpression affecting RhoA activity and myosin light chain phosphorylation levels in cytokinesis.
High CIT expression is associated with prostate cancer.
p27 (show PAK2 Antibodies) has a role in cytokinesis via the regulation of citron-K activity
CIT-K is a crucial abscission regulator that may promote midbody stability through active RhoA (show RHOA Antibodies) and anillin (show ANLN Antibodies).
Hrs inhibits HIV-1 production by inhibiting citron kinase-mediated exocytosis.
Evidence of statistical epistasis between DISC1 (show DISC1 Antibodies), CIT and NDEL1 (show NDEL1 Antibodies) impacting risk for schizophrenia: biological validation with functional neuroimaging.
During cytokinesis, the localization of KIF14 (show KIF14 Antibodies) and citron kinase to the central spindle and midbody is codependent, and they form a complex depending on the activation state of citron kinase.
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants.
citron Rho-interacting kinase
, citron kinase
, citron-K kinase
, postsynaptic density protein (citron)
, citron (rho-interacting, serine/threonine kinase 21)
, rho-interacting, serine/threonine-protein kinase 21
, serine/threonine-protein kinase 21