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CIT encodes a serine/threonine-protein kinase that functions in cell division. Additionally we are shipping CIT Antibodies (26) and CIT Kits (1) and many more products for this protein.
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The CIT-K may promote this event by interacting with TUBB3 and by recruiting at the midbody casein kinase-2alpha (CK2alpha) that has previously been reported to phosphorylate the S444 residue.
Data propose that the CC-domain-mediated translocation and actions of Citron-K ensure proper stabilization of the midbody structure during the transition from constriction to abscission.
p27 (show CDKN1B Proteins) has a role in cytokinesis via the regulation of citron-K activity
CITRON has a role in proliferation of hepatocellular carcinoma cells
Data report that Discs large 5 (Dlg5), a member of the MAGUK family, is an interactor of CitK required for CitK polarization.
Citron-K has a distinct cell cycle-dependent expression pattern and cellular localization as a downstream target of Rho-GTPase (show RACGAP1 Proteins) and functions in the control of G(2)/M transition in the hepatocyte cell cycle
Quantitative analysis of citron kinase in cerebral cortex of knockout mice demonstrates that this molecule is involved in differentially regulating the morphology of the dendritic compartment in corticocollicular projecting pyramidal neurons.
These results suggest that the TTC3-RhoA (show RHOA Proteins)-CIT-K pathway could be a crucial determinant of in vivo neuronal development, whose hyperactivity may result in detrimental effects on the normal differentiation program.
Lack of citron kinase gene in newborn mice profoundly alters barrelfield cortex cell morphology and number.
Proper midbody architecture requires cross-regulation between two cell division kinases, Citron kinase (CIT-K) and Aurora B (show AURKB Proteins), the kinase component of the chromosomal passenger complex.
The TPC1 was shown to interact with citron kinase, with TPC1 overexpression affecting RhoA activity and myosin light chain phosphorylation levels in cytokinesis.
High CIT expression is associated with prostate cancer.
p27 (show PAK2 Proteins) has a role in cytokinesis via the regulation of citron-K activity
CIT-K is a crucial abscission regulator that may promote midbody stability through active RhoA (show RHOA Proteins) and anillin (show ANLN Proteins).
Hrs inhibits HIV-1 production by inhibiting citron kinase-mediated exocytosis.
Evidence of statistical epistasis between DISC1 (show DISC1 Proteins), CIT and NDEL1 (show NDEL1 Proteins) impacting risk for schizophrenia: biological validation with functional neuroimaging.
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants.
citron Rho-interacting kinase
, citron kinase
, citron-K kinase
, postsynaptic density protein (citron)
, citron (rho-interacting, serine/threonine kinase 21)
, rho-interacting, serine/threonine-protein kinase 21
, serine/threonine-protein kinase 21