anti-Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT) Antibodies

CIT encodes a serine/threonine-protein kinase that functions in cell division. Additionally we are shipping CIT Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CIT 83620  
CIT 12704  
CIT 11113 O14578
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Top anti-CIT Antibodies at antibodies-online.com

Showing 10 out of 46 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IF, WB Western blot analysis of CRIK on Rat PC12 cell lysate (ATCC CRL-1721). Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of anti-CRIK. Western blot analysis of CRIK on Human Jurkat cell lysate (ATCC TIB-152). Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-CRIK (5 min exposure). 50 μg Log in to see 6 to 8 Days
$154.07
Details
Human Rabbit Un-conjugated IP, WB 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated ELISA, IF, IHC 100 μL Log in to see 7 to 9 Days
$478.50
Details
Human Rabbit Un-conjugated ELISA, IHC   100 μL Log in to see 16 Days
$175.80
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37 KDa) . 50 μL Log in to see 11 to 12 Days
$298.57
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: Citron Kinase Antibody [NBP1-88050] - Staining of human cerebellum shows strong cytoplasmic positivity in purkinje cells. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated ICC, IF Immunocytochemistry/Immunofluorescence: Citron Antibody  - Staining of human cell line U-2 OS shows localization to cytosol. 100 μL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA   200 μL Log in to see 7 to 9 Days
$1,013.83
Details
Human Rabbit APC IHC, ELISA   200 μL Log in to see 7 to 9 Days
$1,013.83
Details
Human Rabbit PE IHC, ELISA   200 μL Log in to see 7 to 9 Days
$1,013.83
Details

CIT Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)
,
,
Mouse (Murine) ,
,
,
Human , , , ,
,
,
, , , , ,

Top referenced anti-CIT Antibodies

  1. Human Monoclonal CIT Primary Antibody for IF, WB - ABIN968502 : Di Cunto, Calautti, Hsiao, Ong, Topley, Turco, Dotto: Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. in The Journal of biological chemistry 1998 (PubMed)
    Show all 4 references for 968502

  2. Human Polyclonal CIT Primary Antibody for IP, WB - ABIN440556 : Hosono, Yamaguchi, Mizutani, Yanagisawa, Arima, Tomida, Shimada, Hiraoka, Kato, Yokoi, Suzuki, Takahashi: MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis. in The EMBO journal 2012 (PubMed)

More Antibodies against CIT Interaction Partners

Mouse (Murine) Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT) interaction partners

  1. in this study we have provided evidence that ASPM (show ASPM Antibodies) controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM (show ASPM Antibodies) for this activity.

  2. The CIT-K may promote this event by interacting with TUBB3 and by recruiting at the midbody casein kinase-2alpha (CK2alpha) that has previously been reported to phosphorylate the S444 residue.

  3. Data propose that the CC-domain-mediated translocation and actions of Citron-K ensure proper stabilization of the midbody structure during the transition from constriction to abscission.

  4. p27 (show CDKN1B Antibodies) has a role in cytokinesis via the regulation of citron-K activity

  5. CITRON has a role in proliferation of hepatocellular carcinoma cells

  6. Data report that Discs large (show DLG4 Antibodies) 5 (Dlg5 (show DLG5 Antibodies)), a member of the MAGUK family, is an interactor of CitK required for CitK polarization.

  7. Citron-K has a distinct cell cycle-dependent expression pattern and cellular localization as a downstream target of Rho-GTPase (show RACGAP1 Antibodies) and functions in the control of G(2)/M transition in the hepatocyte cell cycle

  8. Quantitative analysis of citron kinase in cerebral cortex of knockout mice demonstrates that this molecule is involved in differentially regulating the morphology of the dendritic compartment in corticocollicular projecting pyramidal neurons.

  9. These results suggest that the TTC3 (show TTC3 Antibodies)-RhoA (show RHOA Antibodies)-CIT-K pathway could be a crucial determinant of in vivo neuronal development, whose hyperactivity may result in detrimental effects on the normal differentiation program.

  10. Lack of citron kinase gene in newborn mice profoundly alters barrelfield cortex cell morphology and number.

Human Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT) interaction partners

  1. in this study we have provided evidence that ASPM (show ASPM Antibodies) controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM (show ASPM Antibodies) for this activity.

  2. Control of abscission requires Eph (show EPHA1 Antibodies) kinase activity, and Src (show SRC Antibodies) and citron kinase (CitK) are downstream effectors in the Eph (show EPHA1 Antibodies)-induced signal transduction cascade

  3. The striking phenotypic overlap between CIT-mutated individuals and the knockout mice and rats that are specifically deficient in the kinase domain supports the proposed causal link between CIT mutation and primary microcephaly in humans.

  4. Splice site variant in CIT, identified in this study, is predicted to abolish splice donor site. cDNA sequence of an affected individual showed retention of an intron next to the splice donor site. The study, presented here, revealed the first variant in the CIT causing Autosomal recessive primary microcephaly in the family.

  5. Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly

  6. identification of recessively inherited pathogenic variants in CIT as the genetic basis of severe microcephaly and neonatal death; and postmortem data showing that CIT is critical to building a normally sized human brain

  7. The CIT-K may promote this event by interacting with TUBB3 and by recruiting at the midbody casein kinase-2alpha (CK2alpha) that has previously been reported to phosphorylate the S444 residue.

  8. Proper midbody architecture requires cross-regulation between two cell division kinases, Citron kinase (CIT-K) and Aurora B (show AURKB Antibodies), the kinase component of the chromosomal passenger complex.

  9. The TPC1 was shown to interact with citron kinase, with TPC1 overexpression affecting RhoA activity and myosin light chain phosphorylation levels in cytokinesis.

  10. Data propose that the CC-domain-mediated translocation and actions of Citron-K ensure proper stabilization of the midbody structure during the transition from constriction to abscission.

CIT Antigen Profile

Protein Summary

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with CIT

  • citron (rho-interacting, serine/threonine kinase 21) (Cit) antibody
  • citron (rho-interacting, serine/threonine kinase 21) (CIT) antibody
  • citron (rho-interacting, serine/threonine kinase 21) (cit) antibody
  • citron (Cit) antibody
  • C030025P15Rik antibody
  • CIT antibody
  • Cit-k antibody
  • CRIK antibody
  • CRIK-SK antibody
  • STK21 antibody
  • xcit antibody

Protein level used designations for CIT

citron Rho-interacting kinase , citron kinase , citron-K kinase , postsynaptic density protein (citron) , citron (rho-interacting, serine/threonine kinase 21) , citron-N , rho-interacting, serine/threonine-protein kinase 21 , serine/threonine-protein kinase 21

GENE ID SPECIES
83620 Rattus norvegicus
416984 Gallus gallus
452298 Pan troglodytes
695846 Macaca mulatta
786852 Bos taurus
100050621 Equus caballus
100083347 Ornithorhynchus anatinus
100145758 Xenopus (Silurana) tropicalis
100153706 Sus scrofa
100348177 Oryctolagus cuniculus
100544730 Meleagris gallopavo
100553665 Anolis carolinensis
12704 Mus musculus
11113 Homo sapiens
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