Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT) ELISA Kits

CIT encodes a serine/threonine-protein kinase that functions in cell division. Additionally we are shipping CIT Antibodies (46) and CIT Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat CIT CIT 83620  
Anti-Mouse CIT CIT 12704  
Anti-Human CIT CIT 11113 O14578
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More ELISA Kits for CIT Interaction Partners

Mouse (Murine) Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT) interaction partners

  1. in this study we have provided evidence that ASPM (show ASPM ELISA Kits) controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM (show ASPM ELISA Kits) for this activity.

  2. The CIT-K may promote this event by interacting with TUBB3 and by recruiting at the midbody casein kinase-2alpha (CK2alpha) that has previously been reported to phosphorylate the S444 residue.

  3. Data propose that the CC-domain-mediated translocation and actions of Citron-K ensure proper stabilization of the midbody structure during the transition from constriction to abscission.

  4. p27 (show CDKN1B ELISA Kits) has a role in cytokinesis via the regulation of citron-K activity

  5. CITRON has a role in proliferation of hepatocellular carcinoma cells

  6. Data report that Discs large 5 (Dlg5), a member of the MAGUK family, is an interactor of CitK required for CitK polarization.

  7. Citron-K has a distinct cell cycle-dependent expression pattern and cellular localization as a downstream target of Rho-GTPase (show RACGAP1 ELISA Kits) and functions in the control of G(2)/M transition in the hepatocyte cell cycle

  8. Quantitative analysis of citron kinase in cerebral cortex of knockout mice demonstrates that this molecule is involved in differentially regulating the morphology of the dendritic compartment in corticocollicular projecting pyramidal neurons.

  9. These results suggest that the TTC3-RhoA (show RHOA ELISA Kits)-CIT-K pathway could be a crucial determinant of in vivo neuronal development, whose hyperactivity may result in detrimental effects on the normal differentiation program.

  10. Lack of citron kinase gene in newborn mice profoundly alters barrelfield cortex cell morphology and number.

Human Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT) interaction partners

  1. in this study we have provided evidence that ASPM (show ASPM ELISA Kits) controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM (show ASPM ELISA Kits) for this activity.

  2. Control of abscission requires Eph (show EPHA1 ELISA Kits) kinase activity, and Src (show SRC ELISA Kits) and citron kinase (CitK) are downstream effectors in the Eph (show EPHA1 ELISA Kits)-induced signal transduction cascade

  3. The striking phenotypic overlap between CIT-mutated individuals and the knockout mice and rats that are specifically deficient in the kinase domain supports the proposed causal link between CIT mutation and primary microcephaly in humans.

  4. Splice site variant in CIT, identified in this study, is predicted to abolish splice donor site. cDNA sequence of an affected individual showed retention of an intron next to the splice donor site. The study, presented here, revealed the first variant in the CIT causing Autosomal recessive primary microcephaly in the family.

  5. Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly

  6. identification of recessively inherited pathogenic variants in CIT as the genetic basis of severe microcephaly and neonatal death; and postmortem data showing that CIT is critical to building a normally sized human brain

  7. The CIT-K may promote this event by interacting with TUBB3 and by recruiting at the midbody casein kinase-2alpha (CK2alpha) that has previously been reported to phosphorylate the S444 residue.

  8. Proper midbody architecture requires cross-regulation between two cell division kinases, Citron kinase (CIT-K) and Aurora B (show AURKB ELISA Kits), the kinase component of the chromosomal passenger complex.

  9. The TPC1 was shown to interact with citron kinase, with TPC1 overexpression affecting RhoA activity and myosin light chain phosphorylation levels in cytokinesis.

  10. Data propose that the CC-domain-mediated translocation and actions of Citron-K ensure proper stabilization of the midbody structure during the transition from constriction to abscission.

CIT Antigen Profile

Antigen Summary

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with CIT

  • citron (rho-interacting, serine/threonine kinase 21) (Cit) antibody
  • citron (rho-interacting, serine/threonine kinase 21) (CIT) antibody
  • citron (rho-interacting, serine/threonine kinase 21) (cit) antibody
  • citron (Cit) antibody
  • C030025P15Rik antibody
  • CIT antibody
  • Cit-k antibody
  • CRIK antibody
  • CRIK-SK antibody
  • STK21 antibody
  • xcit antibody

Protein level used designations for CIT

citron Rho-interacting kinase , citron kinase , citron-K kinase , postsynaptic density protein (citron) , citron (rho-interacting, serine/threonine kinase 21) , citron-N , rho-interacting, serine/threonine-protein kinase 21 , serine/threonine-protein kinase 21

GENE ID SPECIES
83620 Rattus norvegicus
416984 Gallus gallus
452298 Pan troglodytes
695846 Macaca mulatta
786852 Bos taurus
100050621 Equus caballus
100083347 Ornithorhynchus anatinus
100145758 Xenopus (Silurana) tropicalis
100153706 Sus scrofa
100348177 Oryctolagus cuniculus
100544730 Meleagris gallopavo
100553665 Anolis carolinensis
12704 Mus musculus
11113 Homo sapiens
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