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The product of CLSPN is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. Additionally we are shipping Claspin Kits (2) and and many more products for this protein.
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Functional analyses indicat that the expression TopBP1 (show TOPBP1 Antibodies) and Claspin positively affects the survival of brain cancer cells after exposure to radiation.
And-1 coordinates with Claspin for efficient Chk1 (show CHEK1 Antibodies) activation in response to replication stress.
USP29 interacts with Claspin and is able to deubiquitinate it both in vivo and in vitro.
Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.
findings identify claspin as an in vivo substrate for the BRCA1 E3 ligase and suggest that its modification selectively triggers CHK1 (show CHEK1 Antibodies) activation for the homology-directed repair of a subset of genotoxic lesions
analysis of claspin expression could be clinically relevant in the diagnosis of HPV-related cervical lesions, in particular when applied to cervico-vaginal cytology
The conserved C terminus of Claspin interacts with Rad9 (show RAD9A Antibodies) and ensures timely activation of the ATR (show ANTXR1 Antibodies)-Chk1 (show CHEK1 Antibodies) pathway.
the functions of Claspin and the functional relationship between Claspin and Rad17 (show RAD17 Antibodies) were studied.
In the presence of BRCA1, endogenous HERC2 (show HERC2 Antibodies) interacts with Claspin, a protein essential for G(2)-M checkpoint activation and replication fork stability.
The multiple protein-DNA and protein-protein interactions is important for Claspin function during DNA replication and DNA replication checkpoint signaling.
Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1 (show TOPBP1 Antibodies)) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR (show ATR Antibodies)) phosphorylation of checkpoint kinase 1 (Chk1 (show CHEK1 Antibodies)).
Rad9A (show RAD9A Antibodies)-mediated Claspin localization is a vital step during checkpoint activation.
Claspin localizes to mitotic centromeres depending on mitotic SUMOylation.
Claspin is phosphorylated at the midblastula transition at both DNA replication checkpoint-dependent and -independent sites.
recent findings and mechanisms of checkpoint regulation by claspin
the interaction of DDK with Claspin mediates a checkpoint-independent function of Claspin related to DNA replication.
Claspin has roles in the Chk1 (show CHEK1 Antibodies) pathway and functions in checkpoint control [review]
our findings suggest that only transient interaction of Claspin with replication forks potentiates its Chk1 (show CHEK1 Antibodies)-activating function. Also, stable binding of Claspin to chromatin may play a role in other functions besides the activation of Chk1 (show CHEK1 Antibodies).
The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene.
claspin homolog (Xenopus laevis)
, claspin homolog