anti-Claspin (CLSPN) Antibodies

The product of CLSPN is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. Additionally we are shipping Claspin Kits (2) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLSPN 298534  
CLSPN 63967 Q9HAW4
CLSPN 269582 Q80YR7
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Top anti-Claspin Antibodies at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, PLA, WB Detection of human Claspin by Western blot and Immunoprecipitation.  Samples: HeLa Whole cell lysates (20 mcg/lane for WB, 1 mg for IP) Antibody:  ABIN151714 used at the dilution shown for WB (A) and at  1 mcg/ml of lysate for IP and 0.2 mcg/ml for WB (B).  Detection: Chemiluminescence with exposure time of 25 sec. Immunoprecipitation: Claspin Antibody [ABIN151714] - Whole cell lysate (1 mg for IP; 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Claspin antibody used for IP at 6 ug/mg lysate. For blotting immunoprecipitated Claspin,was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated IP, WB Western Blot: Claspin Antibody [ABIN151715] - Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 ug) cells. Affinity purified rabbit anti-Claspin antibody ABIN151715 (lot number 2) used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 6 ug/mg lysate. Claspin was also immunoprecipitated by a previous lot (lot number 1) of this antibody. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B). 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated WB Western Blot: Claspin Antibody [ABIN4298859] - Whole cell lysate (20 ug) from HeLa cells. Antibody used at 1 or 0.5 ug/ml with (+) or without (-) blocking peptide. Western Blot: Claspin Antibody  - Detection of Human Claspin by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa and 293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Claspin antibody  used for WB at 0.2 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 7 to 9 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF Immunocytochemistry/Immunofluorescence: Claspin Antibody  - Staining of human cell line U-251 MG shows localization to nucleoplasm & the Golgi apparatus. 100 μL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated IP, WB   100 μg Log in to see 7 to 9 Days
$815.83
Details
Human Rabbit Un-conjugated IP, WB   100 μL Log in to see 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated IP, WB   100 μL Log in to see 11 to 16 Days
$551.57
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 3 to 4 Days
$157.06
Details
Human Rabbit Un-conjugated IF, IP, IHC (p), PLA, WB   100 μL Log in to see 7 to 9 Days
$595.83
Details

CLSPN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus)


Human ,


Mouse (Murine)


Top referenced anti-Claspin Antibodies

  1. Human Polyclonal Claspin Primary Antibody for ICC, IF - ABIN151714 : Li, Elder, Qin, Park, Liang, Zhao: Phosphatase type 2A-dependent and -independent pathways for ATR phosphorylation of Chk1. in The Journal of biological chemistry 2007 (PubMed)
    Show all 12 Pubmed References

  2. Human Polyclonal Claspin Primary Antibody for WB - ABIN4298859 : Jiang, Pereira, Maxfield, Russell, Goudelock, Sanchez: Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal Claspin Primary Antibody for IP, WB - ABIN151715 : Gao, Inuzuka, Korenjak, Tseng, Wu, Wan, Kirschner, Dyson, Wei: Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. in Molecular biology of the cell 2009 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Claspin Interaction Partners

Human Claspin (CLSPN) interaction partners

  1. Results unveil a new aspect of PERK (show EIF2AK3 Antibodies) function and previously unknown roles for Claspin and Chk1 (show CHEK1 Antibodies) as negative regulators of DNA replication in the absence of genotoxic stress.

  2. found that USP9X (show USP9X Antibodies) regulated the expression and stability of CLASPIN in an S-phase-specific manner. USP9X (show USP9X Antibodies) depletion profoundly impairs the progression of DNA replication forks, causing unscheduled termination events with a frequency similar to CLASPIN depletion, resulting in excessive endogenous DNA damage

  3. Functional analyses indicat that the expression TopBP1 (show TOPBP1 Antibodies) and Claspin positively affects the survival of brain cancer cells after exposure to radiation.

  4. And-1 coordinates with Claspin for efficient Chk1 (show CHEK1 Antibodies) activation in response to replication stress.

  5. USP29 interacts with Claspin and is able to deubiquitinate it both in vivo and in vitro.

  6. Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.

  7. findings identify claspin as an in vivo substrate for the BRCA1 E3 ligase and suggest that its modification selectively triggers CHK1 (show CHEK1 Antibodies) activation for the homology-directed repair of a subset of genotoxic lesions

  8. analysis of claspin expression could be clinically relevant in the diagnosis of HPV-related cervical lesions, in particular when applied to cervico-vaginal cytology

  9. The conserved C terminus of Claspin interacts with Rad9 (show RAD9A Antibodies) and ensures timely activation of the ATR (show ANTXR1 Antibodies)-Chk1 (show CHEK1 Antibodies) pathway.

  10. the functions of Claspin and the functional relationship between Claspin and Rad17 (show RAD17 Antibodies) were studied.

Mouse (Murine) Claspin (CLSPN) interaction partners

  1. Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1 (show TOPBP1 Antibodies)) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR (show ATR Antibodies)) phosphorylation of checkpoint kinase 1 (Chk1 (show CHEK1 Antibodies)).

  2. Rad9A (show RAD9A Antibodies)-mediated Claspin localization is a vital step during checkpoint activation.

Xenopus laevis Claspin (CLSPN) interaction partners

  1. Claspin localizes to mitotic centromeres depending on mitotic SUMOylation.

  2. Claspin is phosphorylated at the midblastula transition at both DNA replication checkpoint-dependent and -independent sites.

  3. recent findings and mechanisms of checkpoint regulation by claspin

  4. the interaction of DDK with Claspin mediates a checkpoint-independent function of Claspin related to DNA replication.

  5. Claspin has roles in the Chk1 (show CHEK1 Antibodies) pathway and functions in checkpoint control [review]

  6. our findings suggest that only transient interaction of Claspin with replication forks potentiates its Chk1 (show CHEK1 Antibodies)-activating function. Also, stable binding of Claspin to chromatin may play a role in other functions besides the activation of Chk1 (show CHEK1 Antibodies).

Claspin (CLSPN) Antigen Profile

Protein Summary

The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-Claspin (CLSPN) Antibodies

  • claspin (Clspn) antibody
  • claspin homolog (Xenopus laevis) (CLSPN) antibody
  • claspin (clspn) antibody
  • claspin (LOC100347850) antibody
  • claspin (CLSPN) antibody
  • B130025E01 antibody
  • C85083 antibody
  • CLSPN antibody
  • E130314M08Rik antibody
  • xClaspin antibody

Protein level used designations for anti-Claspin (CLSPN) Antibodies

claspin homolog (Xenopus laevis) , claspin , claspin homolog , hClaspin , xClaspin

GENE ID SPECIES
298534 Rattus norvegicus
100055244 Equus caballus
456746 Pan troglodytes
100124314 Xenopus (Silurana) tropicalis
100347850 Oryctolagus cuniculus
100482920 Ailuropoda melanoleuca
100525928 Sus scrofa
100543387 Meleagris gallopavo
100567034 Anolis carolinensis
100597024 Nomascus leucogenys
63967 Homo sapiens
269582 Mus musculus
398192 Xenopus laevis
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