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Class II, Major Histocompatibility Complex, Transactivator Proteins (CIITA)

CIITA encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. Additionally we are shipping Class II, Major Histocompatibility Complex, Transactivator Antibodies (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CIITA 12265 P79621
CIITA 4261 P33076
Rat CIITA CIITA 85483  
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Top Class II, Major Histocompatibility Complex, Transactivator Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
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HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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CIITA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Class II, Major Histocompatibility Complex, Transactivator (CIITA) Interaction Partners

Mouse (Murine) Class II, Major Histocompatibility Complex, Transactivator (CIITA) interaction partners

  1. CIITA interacted with and recruited PRMT5 to the MHC II promoter and mediated the synergy between PRMT5 and ASH2/WDR5 to activate MHC II transcription

  2. NLRC5 and CIITA thus emerge as paradigms for a novel class of transcriptional regulators dedicated for transactivating extremely few, phylogenetically related genes.

  3. Data suggest that class II transactivator CIITA expression is likely mediated in hematopoietic cells by common elements with promoter accessibility having a part in promoter choice.

  4. Transfection of CIITA in poorly immunogenic PDA cells resulted in increased expression levels of the MHC class II molecule. CIITA-tumor cells were rejected in 80% to 100% of injected mice.

  5. IFN-gamma exerts a critical anti-inflammatory function in the intestine which protects against colitis by inducing MHCII expression on intestinal epithelial cells.

  6. tumor cell lines with a defective expression of CIITA transcripts lack MHC class II expression

  7. study provides compelling genetic evidence that CIITA, the molecular switch of antigen presentation, plays a novel, unexpected function in skeletal homeostasis, independent of MHC Class II expression and T cells

  8. Data indicate that during Mycobacterium bovis BCG (show SLC11A1 Proteins) infection, iNOS (show NOS2 Proteins)/NO responsive KLF4 (show KLF4 Proteins) induces EZH2 (show EZH2 Proteins) and miR (show MLXIP Proteins)-150 functions to regulate CIITA expression.

  9. CIITA isoform I is dispensable for proper T-cell development.

  10. Mutated major histocompatibility complex class II transactivator up-regulates interleukin-33 (show IL33 Proteins)-dependent differentiation of Th2 subset through Nod2 binding for NLR (show CXCR5 Proteins) (NOD-like receptor) signaling initiation.

Human Class II, Major Histocompatibility Complex, Transactivator (CIITA) interaction partners

  1. CIITA gene alterations are a common mechanism of immune escape through reduction of MHC class II expression in primary mediastinal large B cell lymphoma.

  2. CIITA Isoform III interacts more efficiently with components of the transcription machinery and MHC-II promoter binding proteins.

  3. The dimerization region of Epstein-Barr virus Zta is not required to mediate host CIITA repression.

  4. Thus, CIITA inhibits cytoplasmic and nuclear steps of human T cell lymphotropic virus type 1 Tax-1 (show CNTN2 Proteins)-mediated NF-kappaB (show NFKB1 Proteins) activation.

  5. FOXP1 (show FOXP1 Proteins) represents a novel regulator of genes targeted by the class II MHC (show HLAE Proteins) transactivator CIITA and CD74 (show CD74 Proteins).

  6. Lys (show LYZ Proteins)(63) ubiquitinated CIITA is concentrated in the cytoplasm and following activation of ERK1/2, CIITA phosphorylation occurs and Lys (show LYZ Proteins)=ubiquitinated CIITA translocates to the nucleus.

  7. Genomic alterations underlying immune privilege in malignant lymphomas prominently include structural genomic changes of the CIITA and CD274 (show CD274 Proteins) loci. (Review)

  8. The negative expression of CIITA protein was the key reason for the loss of MHC II expression in HL60 cells.

  9. two DNA-binding proteins, which interact with and regulate PRC2 recruitment to CIITA promoter IV, were identified.

  10. Data indicate that the TC+CC genotypes in the MHC class II transactivator gene (MHC2TA) were significantly associated with increased risk of acute coronary syndromes (ACS) as compared to TT genotype.

Class II, Major Histocompatibility Complex, Transactivator (CIITA) Protein Profile

Protein Summary

This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.

Gene names and symbols associated with CIITA

  • class II, major histocompatibility complex, transactivator (CIITA)
  • class II, major histocompatibility complex, transactivator (ciita)
  • class II transactivator (Ciita)
  • class II, major histocompatibility complex, transactivator (Ciita)
  • C2TA protein
  • CIITA protein
  • CIITAIV protein
  • EG669998 protein
  • Gm9475 protein
  • Mhc2ta protein
  • NLRA protein

Protein level used designations for CIITA

class II, major histocompatibility complex, transactivator , class II transactivator-like , class II transactivator , MHC class II transactivator-like , MHC class II transactivator , MHC class II transactivator type III , NLR family, acid domain containing , nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing , MHC class II transactivator type IV

GENE ID SPECIES
427676 Gallus gallus
453914 Pan troglodytes
508720 Bos taurus
710761 Macaca mulatta
100003537 Danio rerio
100056546 Equus caballus
100338894 Oryctolagus cuniculus
100402996 Callithrix jacchus
100443575 Pongo abelii
12265 Mus musculus
100736732 Sus scrofa
4261 Homo sapiens
85483 Rattus norvegicus
490008 Canis lupus familiaris
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