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CIITA encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. Additionally we are shipping Class II, Major Histocompatibility Complex, Transactivator Antibodies (46) and Class II, Major Histocompatibility Complex, Transactivator Proteins (3) and many more products for this protein.
study found that CIITA exerts a highly restricted control over only the MHCII, H2-DO and H2-DM genes, in DC1 and DC2 cDC (show CDK1 ELISA Kits) subsets, but not over other proposed targets
Decreasing CIITA expression in allogeneic MSCs abolished MHC II induction during myogenic differentiation and prevented immunorejection of these cells from the infarcted myocardium, which enhanced beneficial functional effects of MSC (show MSC ELISA Kits) implantation on myocardial repair.
M. tuberculosis EsxL inhibits antigen presentation by enhancing H3K9me2/3 at the CIITA promoter, thereby repressing its expression through NO and p38 MAPK (show MAPK14 ELISA Kits) activation
this study shows that genetic polymorphisms in the type I promoter of C2ta regulate MHC-II expression and T-cell responses but do not necessarily have a strong impact on autoimmune diseases
CIITA interacted with and recruited PRMT5 to the MHC II promoter and mediated the synergy between PRMT5 and ASH2/WDR5 to activate MHC II transcription
NLRC5 (show NLRC5 ELISA Kits) and CIITA thus emerge as paradigms for a novel class of transcriptional regulators dedicated for transactivating extremely few, phylogenetically related genes.
Data suggest that class II transactivator CIITA expression is likely mediated in hematopoietic cells by common elements with promoter accessibility having a part in promoter choice.
Transfection of CIITA in poorly immunogenic PDA cells resulted in increased expression levels of the MHC class II molecule. CIITA-tumor cells were rejected in 80% to 100% of injected mice.
IFN-gamma exerts a critical anti-inflammatory function in the intestine which protects against colitis by inducing MHCII expression on intestinal epithelial cells.
tumor cell lines with a defective expression of CIITA transcripts lack MHC class II expression
B. abortus lipoproteins via IL-6 (show IL6 ELISA Kits) inhibit the expression of IFN regulatory factor 1 (IRF-1 (show IRF1 ELISA Kits)), a critical regulatory transcription factor for CIITA induction.
Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (show ADAMTS9 ELISA Kits) (rs7631391), DOCK2 (show DOCK2 ELISA Kits) (rs77594147), SLC28A1 (show SLC28A1 ELISA Kits) (rs28649017), ARHGAP5 (show ARHGAP5 ELISA Kits) (rs7151991), and CIITA (rs45601437) in the Asian comparison.
CLPTM1L (show CLPTM1L ELISA Kits) and TERT (show TERT ELISA Kits) have been implicated in cancers, and CIITA is considered as the "master control factor" for the expression of NPC (show NPC1 ELISA Kits)-associated MHC class II (show HLA-DPA1 ELISA Kits) genes. These suggested that both SNPs might be functional. Altogether, our findings expand our understanding of the genetic contribution to NPC (show NPC1 ELISA Kits) risk and provide novel biological insights into NPC (show NPC1 ELISA Kits) pathogenesis.
When mouse pDCs and CAL-1 cells were stimulated by GM-CSF, mRNA levels of PU.1, pIII-driven CIITA, total CIITA, MHC class II, and the amount of PU.1 binding to pIII were significantly increased
the MHC2TA -168 A/G polymorphism is not associated with susceptibility to rheumatoid arthritis in Caucasians [meta-analysis]
Observed no association between the MHC2TA or FCRL3 (show FCRL3 ELISA Kits) SNPs and rheumatoid arthritis in Mexican patients.
CIITA acts as a general restriction factor against HIV-1 not only in T cells but also in myeloid cells.
CIITA gene alterations are a common mechanism of immune escape through reduction of MHC class II expression in primary mediastinal large B cell lymphoma.
CIITA Isoform III interacts more efficiently with components of the transcription machinery and MHC-II promoter binding proteins.
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
class II, major histocompatibility complex, transactivator
, class II transactivator-like
, class II transactivator
, MHC class II transactivator-like
, MHC class II transactivator
, MHC class II transactivator type III
, NLR family, acid domain containing
, nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
, MHC class II transactivator type IV